The ubiquitin ligase Itch limits the way B cells respond to the GC environment.
Itch restricts the accumulation of light zone GC B cells.
Itch-deficient GC B cells require less Tfh cell help.
IMMUNE SYSTEM DEVELOPMENT
Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development
HVEM expressed in thymocytes provided signals for positive selection.
HVEM deficiency in positive selection led to memory-like CD8 thymocyte development.
Interaction of Nmi and IFP35 Promotes Mutual Protein Stabilization and IRF3 and IRF7 Degradation to Suppress Type I IFN Production in Teleost Fish
Nmi can interact with IRF3 and IRF7 to regulate negatively type I IFN expression.
Nmi and IFP35 can interact with each other to maintain mutual stabilization.
IgGC is favored upon AID activity in G1.
SHM: AID activity in G1 is required for the A/T mutator, but not for C/G mutagenesis.
CSR is observed exclusively upon AID activity in G1.
IMMUNOTHERAPY AND VACCINES
The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells
The adjuvant combination of dmLT and MPL-A can induce significant T cell expansion.
The adjuvant combination activates the NLRP3 inflammasome in dendritic cells.
The combination adjuvant IL-1β release from dendritic cells is gasdermin D–independent.
INFECTIOUS DISEASE AND HOST RESPONSE
High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis–Infected Macrophages to CD8 T Cells
High intracellular M. tuberculosis load and macrophage death are associated with CD8 activation.
CD8 T cell recognition of infected macrophages requires expression of the ESX-1 locus.
Bystander APC scavenge cellular debris and cross-present M. tuberculosis Ag to CD8 T cells.
INNATE IMMUNITY AND INFLAMMATION
MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity
Mouse MASP3 converts pro-FD to mature FD, consistent with previous findings.
Unlike what has been reported earlier, mouse pro-FD has catalytic activity.
MASP3 deficiency in mice reduces but does not abrogate AP complement activity.
Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas
The primary syncytiotrophoblast model expresses functional dsRNA receptors.
The syncytiotrophoblast model releases IFNs in response to dsRNA.
dsRNA induces apoptosis of the syncytiotrophoblast model.
Mycobacterium tuberculosis–Induced Prostaglandin J2 and 15-Deoxy-Prostaglandin J2 Inhibit Inflammatory Signals in Human M1 Macrophages via a Negative Feedback Loop
M. tuberculosis–derived factors elevate COX-2 expression and J2-PG formation in macrophages.
J2-PGs inhibit COX-2 expression and cytokine release via a negative feedback loop.
J2-PGs regulate COX-2 via DP1/DP2 receptors seemingly involving TAK1/NF-κB/MAPK.
A Single Nasal Dose Vaccination with a Brucella abortus Mutant Potently Protects against Pulmonary Infection
A single nasal dose of znBAZ protects against wild-type Brucella challenge.
Protection is conferred by CD8+ T cells.
Nasal vaccination induces lung IFN-γ+ CD4+ and CD8+ TRMs.
Tumor Suppressor Adenomatous Polyposis Coli Sustains Dendritic Cell Tolerance through IL-10 in a β-Catenin–Dependent Manner
APC deficiency in DC impairs antitumor capacity in mice.
APC-deficient DC promote Treg cell induction and suppress CD8+ T cells priming.
APC-deficiency maintains DC tolerance through the intrinsic β-catenin/IL-10 axis.
IL-12 and IL-27 Promote CD39 Expression on CD8+ T Cells and Differentially Regulate the CD39+CD8+ T Cell Phenotype
IL-12 and IL-27 induce CD39 expression on CD8+ T cells in vitro.
IL-27 limited IL-12–mediated induction of exhaustion markers on CD39+CD8+ T cells.
IL-12 and IL-27 differentially affect CD39+CD8+ T cell functionality.
NOVEL IMMUNOLOGICAL METHODS
FLAIRR-Seq: A Method for Single-Molecule Resolution of Near Full-Length Antibody H Chain Repertoires
FLAIRR-seq simultaneously resolves Ab V and C region genes.
FLAIRR-seq data can be used for subisotype-specific repertoire characterization.
FLAIRR-seq performs robustly using RNA derived from cells or whole blood.
On the cover: TB10.4-specific CD8 T cells interact with Mycobacterium tuberculosis–infected macrophages. Macrophages were infected overnight with approximately eight bacilli per macrophage. Scanning microscopy was used to quantify CD8 T cells interacting with M. tuberculosis–infected macrophages. T cells (white, CD3), macrophages (red, F4/80), M. tuberculosis (green, H37Rv.YFP), nuclei (blue, DAPI). Original magnification ×20. Mott, D., J. Yang, C. Baer, K. Papavinasasundaram, C. M. Sassetti, and S. M. Behar. 2023. High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis–infected macrophages to CD8 T cells. J. Immunol. 210: 1531–1542.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkEditorial Board