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J Immunol (2023) 210 (10): 1461.

BRIEF REVIEWS

J Immunol (2023) 210 (10): 1463–1472.

AUTOIMMUNITY

J Immunol (2023) 210 (10): 1473–1481.

  • The ubiquitin ligase Itch limits the way B cells respond to the GC environment.

  • Itch restricts the accumulation of light zone GC B cells.

  • Itch-deficient GC B cells require less Tfh cell help.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2023) 210 (10): 1482–1493.

  • HVEM expressed in thymocytes provided signals for positive selection.

  • HVEM deficiency in positive selection led to memory-like CD8 thymocyte development.

IMMUNOGENETICS

J Immunol (2023) 210 (10): 1494–1507.

  • Nmi can interact with IRF3 and IRF7 to regulate negatively type I IFN expression.

  • Nmi and IFP35 can interact with each other to maintain mutual stabilization.

J Immunol (2023) 210 (10): 1508–1518.

  • IgGC is favored upon AID activity in G1.

  • SHM: AID activity in G1 is required for the A/T mutator, but not for C/G mutagenesis.

  • CSR is observed exclusively upon AID activity in G1.

IMMUNOTHERAPY AND VACCINES

J Immunol (2023) 210 (10): 1519–1530.

  • The adjuvant combination of dmLT and MPL-A can induce significant T cell expansion.

  • The adjuvant combination activates the NLRP3 inflammasome in dendritic cells.

  • The combination adjuvant IL-1β release from dendritic cells is gasdermin D–independent.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2023) 210 (10): 1531–1542.

  • High intracellular M. tuberculosis load and macrophage death are associated with CD8 activation.

  • CD8 T cell recognition of infected macrophages requires expression of the ESX-1 locus.

  • Bystander APC scavenge cellular debris and cross-present M. tuberculosis Ag to CD8 T cells.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2023) 210 (10): 1543–1551.

  • Mouse MASP3 converts pro-FD to mature FD, consistent with previous findings.

  • Unlike what has been reported earlier, mouse pro-FD has catalytic activity.

  • MASP3 deficiency in mice reduces but does not abrogate AP complement activity.

J Immunol (2023) 210 (10): 1552–1563.

  • The primary syncytiotrophoblast model expresses functional dsRNA receptors.

  • The syncytiotrophoblast model releases IFNs in response to dsRNA.

  • dsRNA induces apoptosis of the syncytiotrophoblast model.

J Immunol (2023) 210 (10): 1564–1575.

  • M. tuberculosis–derived factors elevate COX-2 expression and J2-PG formation in macrophages.

  • J2-PGs inhibit COX-2 expression and cytokine release via a negative feedback loop.

  • J2-PGs regulate COX-2 via DP1/DP2 receptors seemingly involving TAK1/NF-κB/MAPK.

MUCOSAL IMMUNOLOGY

J Immunol (2023) 210 (10): 1576–1588.

  • A single nasal dose of znBAZ protects against wild-type Brucella challenge.

  • Protection is conferred by CD8+ T cells.

  • Nasal vaccination induces lung IFN-γ+ CD4+ and CD8+ TRMs.

TUMOR IMMUNOLOGY

J Immunol (2023) 210 (10): 1589–1597.

  • APC deficiency in DC impairs antitumor capacity in mice.

  • APC-deficient DC promote Treg cell induction and suppress CD8+ T cells priming.

  • APC-deficiency maintains DC tolerance through the intrinsic β-catenin/IL-10 axis.

J Immunol (2023) 210 (10): 1598–1606.

  • IL-12 and IL-27 induce CD39 expression on CD8+ T cells in vitro.

  • IL-27 limited IL-12–mediated induction of exhaustion markers on CD39+CD8+ T cells.

  • IL-12 and IL-27 differentially affect CD39+CD8+ T cell functionality.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2023) 210 (10): 1607–1619.

  • FLAIRR-seq simultaneously resolves Ab V and C region genes.

  • FLAIRR-seq data can be used for subisotype-specific repertoire characterization.

  • FLAIRR-seq performs robustly using RNA derived from cells or whole blood.

CORRECTIONS

J Immunol (2023) 210 (10): 1620.
J Immunol (2023) 210 (10): 1621–1622.
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