Complement: The Road Less Traveled
Topoisomerases in Immune Cell Development and Function
CLINICAL AND HUMAN IMMUNOLOGY
Long Noncoding RNA HAFML Promotes Migration and Invasion of Rheumatoid Fibroblast-like Synoviocytes
We identify an lncRNA, HAFML, which promotes the aggression of RA FLS.
HAFML regulates RA FLS invasion by combining with HuR to control APPL2 mRNA stability.
Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens
B-1b cell–intrinsic IFNAR expression promotes TI-2 Ab responses.
MPL/TDCM adjuvant effects are independent of type 1 IFN.
MPL/TDCM promotes TI-2 Ab responses by innate B cells.
IgG Fab Glycans Hinder FcRn-Mediated Placental Transport
The presence of Fab glycans hinders IgG interaction with hFcRn in a cell-based assay.
Membrane context likely plays a key role, which conventional assays do not show.
Impaired placental transfer further illustrates the hindering effect of Fab glycans.
INFECTIOUS DISEASE AND HOST RESPONSE
Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition
Susceptibility and loss of 1° and 4° memory CD8 T cells are similar after sepsis.
Primary memory CD8 T cells become overrepresented over time in sepsis survivors.
Sepsis leads to changes in subset composition of the memory CD8 T cell pool.
INNATE IMMUNITY AND INFLAMMATION
JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury
JMJD3 is required for acute pancreatitis in mouse models.
mtDNA contributes to lung injury through the STING/TLR9-NF-κB-JMJD3-TNF-α pathway.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
TBK1 Isoform Inhibits Grass Carp Reovirus Infection by Targeting the Degradation of Viral Nonstructural Proteins NS80 and NS38
gcTBK1_tv3 inhibits the replication and infection of GCRV.
gcTBK1_tv3 promotes the degradation of NS80 or NS38.
gcTBK1_tv3 impairs the production of cytoplasmic VIBs.
AL008 Enhances Myeloid Antitumor Function by Inhibiting SIRPα Signaling and Activating Fc Receptors
AL008 induces SIRPα degradation and immune activation through FcγR2A engagement.
AL008 promotes T cell proliferation more effectively than anti-CD47 Abs.
In vivo, AL008 demonstrated antitumor activity alone or with anti–PD-L1.
On the cover: A representative image showing in vitro invasion of rheumatoid arthritis fibroblast-like synoviocytes, which were infected with HAFML overexpression lentivirus. Xu, S., D. Liu, Y. Kuang, R. Li, J. Wang, M. Shi, Y. Zou, Q. Qiu, L. Liang, Y. Xiao, and H. Xu. 2023. Long noncoding RNA HAFML promotes migration and invasion of rheumatoid fibroblast-like synoviocytes. J. Immunol. 210: 135–147.
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