Issues

We identify an lncRNA, HAFML, which promotes the aggression of RA FLS.

HAFML regulates RA FLS invasion by combining with HuR to control APPL2 mRNA stability.

B-1b cell–intrinsic IFNAR expression promotes TI-2 Ab responses.

MPL/TDCM adjuvant effects are independent of type 1 IFN.

MPL/TDCM promotes TI-2 Ab responses by innate B cells.

The presence of Fab glycans hinders IgG interaction with hFcRn in a cell-based assay.

Membrane context likely plays a key role, which conventional assays do not show.

Impaired placental transfer further illustrates the hindering effect of Fab glycans.

Susceptibility and loss of 1° and 4° memory CD8 T cells are similar after sepsis.

Primary memory CD8 T cells become overrepresented over time in sepsis survivors.

Sepsis leads to changes in subset composition of the memory CD8 T cell pool.

JMJD3 is required for acute pancreatitis in mouse models.

mtDNA contributes to lung injury through the STING/TLR9-NF-κB-JMJD3-TNF-α pathway.

gcTBK1_tv3 inhibits the replication and infection of GCRV.

gcTBK1_tv3 promotes the degradation of NS80 or NS38.

gcTBK1_tv3 impairs the production of cytoplasmic VIBs.

AL008 induces SIRPα degradation and immune activation through FcγR2A engagement.

AL008 promotes T cell proliferation more effectively than anti-CD47 Abs.

In vivo, AL008 demonstrated antitumor activity alone or with anti–PD-L1.