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J Immunol (2023) 210 (3): 217.

PILLARS OF IMMUNOLOGY

J Immunol (2023) 210 (3): 219–220.

This Pillars of Immunology article is a commentary on “Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival,” a pivotal article written by L. A. Myers, D. D. Patel, J. M. Puck, and R. H. Buckley, and published in Blood, in 2002. https://pubmed.ncbi.nlm.nih.gov/11806989/.

BRIEF REVIEWS

J Immunol (2023) 210 (3): 221–227.

IMMUNE REGULATION

J Immunol (2023) 210 (3): 229–244.

  • IL-10 suppresses T cell activation, proliferation, and effector function of tilapia.

  • Tilapia IL-10 triggers the JAK1/STAT3/SOCS3 axis to inhibit the NF-κB and MAPK/ERK pathway.

  • Tilapia evolved sophisticated mechanisms to negatively regulate T cell immunity.

J Immunol (2023) 210 (3): 245–258.

  • CgDM9CP-5 was expressed at the highest level in the gill tissue of oysters.

  • CgDM9CP-5 exhibited binding activities to microbes as well as various PAMPs.

  • The CgDM9CP-5-integrin-MAPK pathway regulated the release of CgIL-17s and Cgdefensins.

IMMUNOTHERAPY AND VACCINES

J Immunol (2023) 210 (3): 259–270.

  • Mice orally vaccinated with Yptb1(pYA5199) accumulated lung CD4 and CD8 TRM cells.

  • Lung TRM cells expressed IFN-γ, and IL-17A played a vital role against pneumonic plague.

  • Oral Yptb1(pYA5199) vaccination developed long-lived immunity in the lung.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2023) 210 (3): 271–282.

  • scRNA-seq was first used to reveal transcriptome changes in PEDV-infected jejunum.

  • PEDV effectively infects goblet cells and decreases the expression of MUC2.

  • IL-33 and STAT3 play roles in PEDV inducing REG3G, which inhibits PEDV replication.

J Immunol (2023) 210 (3): 283–296.

  • FMDV leader protease inhibits IFN-β–induced innate immune response.

  • FMDV Lpro interacts with STAT1/2 to cleave STAT1/2 through protease activity.

  • 252–502 aa of STAT1 and 140–150 aa of STAT2 are critical for Lpro cleavage.

J Immunol (2023) 210 (3): 297–309.

  • Helminth infection–driven increases in TVM cells are caused by IL-15.

  • The impact on TVM cells after helminth infection is not maintained into old age.

  • Intrinsic and extrinsic age-associated changes prevented an increase in TVM cells.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2023) 210 (3): 310–321.

  • eCIRP induces CD112 (Nectin-2)-expressing neutrophils in sepsis via the TLR4 pathway.

  • CD112+ neutrophils induce the Th1 phenotype when cocultured with CD4 T cells.

J Immunol (2023) 210 (3): 322–334.

  • Noncanonical inflammasome activation triggers release of extracellular vesicles.

  • This EV secretion is caspase-4–, NLRP3- and type I IFN–dependent.

  • PGJ2 and parthenolide inhibit inflammation and EV release upon LPS transfection.

J Immunol (2023) 210 (3): 335–347.

  • Theilovirus 3C protease cleaves the innate immune viral sensor MDA5.

  • The proteolytic cleavage abrogates viral RNA recognition by MDA5.

  • The cleavage-resistant MDA5 gains an IFN response against Saffold virus infection.

MUCOSAL IMMUNOLOGY

J Immunol (2023) 210 (3): 348–355.

  • Low-dose LPS before, but not after, respiratory viral infection increases survival.

  • LPS-mediated survival depends on macrophages, but not neutrophils.

  • LPS provides a survival advantage through type I IFN and TLR4-MyD88 signaling.

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