PILLARS OF IMMUNOLOGY
Murine Cytomegalovirus Encodes a Specific Cell Surface Marker That Can Trigger Attack by NK Cells
The Adaptation Model of Immunity: Signal IV Matters Most in Determining the Functional Outcomes of Immune Responses
Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout
TRAF1 reduces linear ubiquitination of ASC to limit inflammasome activation.
Monosodium urate (MSU)-induced peritonitis is exacerbated in mice lacking TRAF1.
TRAF1-deficient mice are more susceptible to a model of MSU crystal–induced gout.
ALLERGY AND OTHER HYPERSENSITIVITIES
ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation
ERG binds to and regulates Il9.
ERG functionally overlaps with other ETS family members.
ERG-dependent IL-9 production is important for allergic airway inflammation.
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
We demonstrate a causal link between prolidase deficiency and autoimmunity.
Loss of PEPD leads to an Ag-independent increase in effector CD8 T cells.
Cell-extrinsic expansion of KLRG1+ CD8 effectors is associated with PEPD autoimmunity.
Combination CTLA4Ig and Anti–CD40 Ligand Treatment Modifies T and B Cell Metabolic Profiles and Promotes B Cell Receptor Remodeling in a Mouse Model of Systemic Lupus Erythematosus
Short-term combination costimulatory blockade induces B cell tolerance in NZB/W mice.
Combination treatment modulates CD4 T cell metabolism in aged NZB/W mice.
Combination treatment remodels BCR signaling in germinal centers of aged NZB/W mice.
CLINICAL AND HUMAN IMMUNOLOGY
Expression of Inhibitory Receptors TIGIT, TIM-3, and LAG-3 on CD4+ T Cells from Patients with Different Clinical Forms of Chronic Chagas Disease
Chronic Chagas disease patients have higher baseline TIGIT expression than do naive donors.
TIM-3 is upregulated in chronic Chagas disease patients upon parasite Ag stimulation.
Upon stimulation, nonactivated cells from asymptomatic patients express LAG-3.
Increased Inflammasome Activation Is Associated with Aging and Chronic Myelomonocytic Leukemia Disease Severity
Aging increases IL-1β production upon NLRP3 activation in human monocytes.
Pam3CSK4 directly activates the NLRP3 inflammasome in monocytes from older people.
Increased NLRP3 activation showed increased disease severity in CMML patients.
Elevated Levels of the Cytokine LIGHT in Pediatric Crohn’s Disease
The cytokine LIGHT/TNFSF14 is elevated 5- to 10-fold in pediatric Crohn’s disease.
LIGHT levels do not predict clinical features in a biobank population.
TNF-α Limits Serological Memory by Disrupting the Bone Marrow Niche
TNF-α depletes Ag-specific BM PCs and shortens serological memory.
TNF-αR1 in radiation-resistant cells is required to mobilize BM PCs.
IMMUNOTHERAPY AND VACCINES
Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization
To our knowledge, we have composed the first true adjuvant for Treg cells.
It requires immunosuppressive and immunogenic agents as two essential ingredients.
INFECTIOUS DISEASE AND HOST RESPONSE
Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis
Enhancing ILC2 numbers increases Francisella tularensis bacterial burden.
Reducing ILC2 numbers promotes Francisella tularensis bacterial clearance.
IFN-γ reduces ILC2s, with ILC2 production of IL-5 detrimental to bacterial clearance.
Intermediate Levels of Pre-Existing Protective Antibody Allow Priming of Protective T Cell Immunity against Influenza
A range of transferred IAV-specific Abs protects mice from lethal homotypic IAV.
Detectable IAV-specific T cell priming occurs in the presence of pre-existing Ab.
Protective T cell immunity decreases with increasing pre-existing IAV-specific Ab.
INNATE IMMUNITY AND INFLAMMATION
USP39 Regulates NF-κB–Mediated Inflammatory Responses through Deubiquitinating K48-Linked IκBα
USP39 negatively regulates the NF-κB activation by stabilizing basal IκBα.
USP39 reduces K48-linked polyubiquination of IκBα.
The m6A Reader YTHDF2 Modulates Antiviral and Antibacterial Activity by Suppressing METTL3 Methylation-Modified STING in Fish
The total m6A level increased during SCRV and V. anguillarum infection in fish.
STING participates in the antibacterial immunity of fish.
YTHDF2 weakens innate immunity by degrading STING m6A modified by METTL3.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek’s Disease
Chicken haplotype B19 confers greater susceptibility to Marek’s disease than does B15.
BF2*1901 binds peptides with a greater variety of specific anchors than BF2*1501.
The narrower and shallower groove of BF2*1901 confers weaker binding to most peptides.
A Novel TrxR1 Inhibitor Regulates NK and CD8+ T Cell Infiltration and Cytotoxicity, Enhancing the Efficacy of Anti–PD-1 Immunotherapy against Hepatocarcinoma
Butaselen enhances NK and T cell activity and tumor infiltration.
Butaselen exerts a synergistic antitumor effect in combination with PD-1 blockade.
On the cover: The peptide-binding groove for the chicken class I molecule BF2*1901 is narrower and shallower compared to the groove of BF2*1501, which is correlated with the relative susceptibility to Marek’s disease. The electrostatic plot shows the peptide binding groove of chicken class I molecule BF2*1901 complexed to Marek’s disease virus peptide RY8 in sticks. Han, L., S. Wu, T. Zhang, W. Peng, M. Zhao, C. Yue, W. Wen, W. Cai, M. Li, H.-J. Wallny, D. W. Avila, W. Mwangi, V. Nair, N. Ternette, Y. Guo, Y. Zhao, Y. Chai, J. Qi, H. Liang, G. F. Gao, J. Kaufman, and W. J. Liu. 2023. A wider and deeper peptide-binding groove for the class I molecules from B15 compared with B19 chickens correlates with relative resistance to Marek’s disease. J. Immunol. 210: 668–680.
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