Issues

TRAF1 reduces linear ubiquitination of ASC to limit inflammasome activation.

Monosodium urate (MSU)-induced peritonitis is exacerbated in mice lacking TRAF1.

TRAF1-deficient mice are more susceptible to a model of MSU crystal–induced gout.

ERG binds to and regulates Il9.

ERG functionally overlaps with other ETS family members.

ERG-dependent IL-9 production is important for allergic airway inflammation.

We demonstrate a causal link between prolidase deficiency and autoimmunity.

Loss of PEPD leads to an Ag-independent increase in effector CD8 T cells.

Cell-extrinsic expansion of KLRG1⁺ CD8 effectors is associated with PEPD autoimmunity.

Short-term combination costimulatory blockade induces B cell tolerance in NZB/W mice.

Combination treatment modulates CD4 T cell metabolism in aged NZB/W mice.

Combination treatment remodels BCR signaling in germinal centers of aged NZB/W mice.

Chronic Chagas disease patients have higher baseline TIGIT expression than do naive donors.

TIM-3 is upregulated in chronic Chagas disease patients upon parasite Ag stimulation.

Upon stimulation, nonactivated cells from asymptomatic patients express LAG-3.

Aging increases IL-1β production upon NLRP3 activation in human monocytes.

Pam3CSK4 directly activates the NLRP3 inflammasome in monocytes from older people.

Increased NLRP3 activation showed increased disease severity in CMML patients.

The cytokine LIGHT/TNFSF14 is elevated 5- to 10-fold in pediatric Crohn’s disease.

LIGHT levels do not predict clinical features in a biobank population.

TNF-α depletes Ag-specific BM PCs and shortens serological memory.

TNF-αR1 in radiation-resistant cells is required to mobilize BM PCs.

To our knowledge, we have composed the first true adjuvant for Treg cells.

It requires immunosuppressive and immunogenic agents as two essential ingredients.

Enhancing ILC2 numbers increases Francisella tularensis bacterial burden.

Reducing ILC2 numbers promotes Francisella tularensis bacterial clearance.

IFN-γ reduces ILC2s, with ILC2 production of IL-5 detrimental to bacterial clearance.

A range of transferred IAV-specific Abs protects mice from lethal homotypic IAV.

Detectable IAV-specific T cell priming occurs in the presence of pre-existing Ab.

Protective T cell immunity decreases with increasing pre-existing IAV-specific Ab.

USP39 negatively regulates the NF-κB activation by stabilizing basal IκBα.

USP39 reduces K48-linked polyubiquination of IκBα.

The total m⁶A level increased during SCRV and V. anguillarum infection in fish.

STING participates in the antibacterial immunity of fish.

YTHDF2 weakens innate immunity by degrading STING m⁶A modified by METTL3.

Chicken haplotype B19 confers greater susceptibility to Marek’s disease than does B15.

BF2*1901 binds peptides with a greater variety of specific anchors than BF2*1501.

The narrower and shallower groove of BF2*1901 confers weaker binding to most peptides.

Butaselen enhances NK and T cell activity and tumor infiltration.

Butaselen exerts a synergistic antitumor effect in combination with PD-1 blockade.