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J Immunol (2023) 210 (8): 1013.

BRIEF REVIEWS

J Immunol (2023) 210 (8): 1015–1024.

CUTTING EDGE

J Immunol (2023) 210 (8): 1025–1030.

  • Airway and vasccular labeling identifies compartmentalized influenza TRM.

  • CD11alo airway TRM exhibit reduced IFN-γ after in vitro peptide stimulation.

  • CD11alo airway TRM produce minimal IFN-γ or CD25 after in vivo stimulation.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2023) 210 (8): 1031–1042.

  • Nitroso dapsone–modified HLA binding peptides activate human CD8+ T cells.

  • T cell activation was restricted to HLA-B*13:01.

IMMUNE REGULATION

J Immunol (2023) 210 (8): 1043–1058.

  • IFN1 enhances phagocytosis via the IFN receptor complex-JAK/STAT-C3.3-CR1 pathway.

  • The complements can aggregate bacteria in teleost.

  • IFN1 demonstrates effective antibacterial activity at physiological status.

J Immunol (2023) 210 (8): 1059–1073.

  • IL-9R is highly upregulated on mouse TRAF3-deficient B lymphocytes.

  • IL-9 enhances CSR induced by BCR crosslinking plus IL-4 in TRAF3-deficient B cells.

  • JAK or STAT3 inhibitors abrogate the enhancing effect of IL-9 on CSR.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2023) 210 (8): 1074–1085.

  • IAV-derived AM58–66GL9-paralleled peptide in IBV is an HLA-B*1501 T cell epitope.

  • BM58–66AF9 is presented in a similar featureless conformation as AM58–66GL9.

  • The sequence around BM58–66AF9 epitope does not overlap with an NES.

J Immunol (2023) 210 (8): 1086–1097.

  • C. pneumoniae lung infection causes lipolysis in WAT in a FABP4-dependent manner.

  • Infection-induced FABP4 secretion augments ER stress and promotes M1-like ATMs.

  • The presence of FABP4 either in adipocytes or ATMs is required to induce WAT pathology.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2023) 210 (8): 1098–1107.

  • cGAS promotes the macrophage phenotype switch to the M1 phenotype via the mTORC1 pathway.

  • cGAS is activated by mtDNA and further acts as a polarization switch in inflammation.

  • Deletion of Cgas significantly ameliorates sepsis-induced acute lung injury.

J Immunol (2023) 210 (8): 1108–1122.

  • Ablating FcRγ or PLZF from expanded primary human NK cells does not affect ADCC.

  • Ablating SYK increases ADCC in NK cells whereas ablating ZAP70 decreases ADCC.

  • The enhanced function of SYK-ablated cells is retained up to 27 d post-CRISPR.

J Immunol (2023) 210 (8): 1123–1133.

  • NIK-deficient macrophages exhibit impaired mitochondrial oxidative phosphorylation.

  • NIK-deficient mice have more inflammatory myeloid cells in blood and bone marrow.

  • NIK-dependent metabolic rewiring shapes pro- and anti-inflammatory innate immunity.

TRANSPLANTATION

J Immunol (2023) 210 (8): 1134–1145.

  • Statins induced cytoplasmic YAP localization and inhibited its activity in human ECs.

  • Mevalonic acid or geranylgeraniol reversed the inhibitory effect of statins on YAP.

  • Statins inhibit YAP Tyr357 phosphorylation, which is critical for YAP activation.

TUMOR IMMUNOLOGY

J Immunol (2023) 210 (8): 1146–1155.

  • DC2 limit initial metastatic burden in the lung.

  • In response to tumor-derived nucleic acids, DC2 produce host-required IL-12p40.

  • Local DC2 and NK cells coordinate initial metastatic control.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2023) 210 (8): 1156–1165.

  • Quality and stability of fluorescent ligand tetramers can vary from batch to batch.

  • Ligand tetramers can be sensitively assessed using Abs bound to beads.

J Immunol (2023) 210 (8): 1166–1176.

  • A novel real-time and quantitative image-based efferocytosis assay was established.

  • Removal of cell debris in the meal resulted in relatively specific efferocytosis.

  • The new method is applicable to both basic research and drug discovery.

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