Issues

Mutations to BTN2A1 L318 and L325, but not C247, C265, or EKE282, block pAg response.

BTN2A1 cytoplasmic domain is a stable dimer that interacts with HMBPP-bound BTN3A1.

L325G mutation disrupts BTN2A1 dynamics, dimerization, and affinity to BTN3A1:HMBPP.

Pain-mediated relapse of neuroinflammation is dependent on GM-CSF.

GM-CSF from CNS endothelial cells maintains MHC class II^Hi myeloid cells.

GM-CSF blockade during remission may ameliorate relapse of neuroinflammation.

Bacteria-induced yorkie translocated from the nuclei into the cytoplasm.

Interaction between yorkie and CRM1 is essential for its subcellular translocation.

PRP4K phosphorylates yorkie and promotes its interaction with CRM1.

Cancer cells upregulate surface MARCO expression on macrophages via STAT3 activation.

MARCO induces M2 polarization with increased expression of IL-10 and PD-L1.

MARCO ligation suppresses T cell response mainly by decreasing their proliferation.

Spi-C negatively regulates Rag1, Rag2, and Igκ transcription.

PU.1 positively regulates Rag1, Rag2, and Igκ transcription.

Spi-C and PU.1 both interact with a site in the Rag1 promoter.

Recent thymic emigrants transition into mature naive cells via a CD45RB^int stage.

Immature naive T cells require Notch signals to undergo functional differentiation.

Immature naive T cells display a bias toward IL-17 production.

Mst1^−/− promotes the differentiation and maturation of neutrophils from GMPs.

Glycolysis and SDH-mediated OXPHOS regulate the granulopoiesis initiated by MST1.

MST1-mTOR-HIF1α–mediated cell metabolism reprograms the differentiation of GMPs.

iC3b/CD11b receptor–mediated phagocytosis of Leishmania is proparasitic.

Leishmania internalization, not infection, induces phosphatidylserine expression.

Leishmania internalization induces a state of “stalled apoptosis” in neutrophils.

CCL28/CCR10 protects the vaginal mucosal from herpes infection and disease.

CCL28/CCR10 mobilizes memory CCR10⁺CD44⁺CD8⁺ T cells into the vaginal mucosa.

CCL28/CCR10 mobilizes memory CCR10⁺B220⁺CD27⁺ B cells into the vaginal mucosa.

m⁶A writer METTL3 expression increases when miiuy croaker is infected by pathogens.

The methylase activity of METTL3 inhibits innate immunity to infections.

METTL3 controls TRIF and MyD88 levels in a YTHDF2/3 reader–dependent manner.

The cellular map of the larval silkworm fat body was constructed.

Metabolic responses in fat body tend to be inhibited after BmNPV infection.

A robust immune response was induced in fat body cell subsets by BmNPV infection.

scRNA/CITE-seq results show that decidual T cells maintain a unique transcriptome.

Decidual T cells overexpress negative regulators of inflammatory pathways.

Specific decidual T cell clusters display lower clonotype diversity.