PILLARS OF IMMUNOLOGY
ANTIGEN RECOGNITION AND RESPONSES
Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen–Bound BTN3A1
Mutations to BTN2A1 L318 and L325, but not C247, C265, or EKE282, block pAg response.
BTN2A1 cytoplasmic domain is a stable dimer that interacts with HMBPP-bound BTN3A1.
L325G mutation disrupts BTN2A1 dynamics, dimerization, and affinity to BTN3A1:HMBPP.
GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation
Pain-mediated relapse of neuroinflammation is dependent on GM-CSF.
GM-CSF from CNS endothelial cells maintains MHC class IIHi myeloid cells.
GM-CSF blockade during remission may ameliorate relapse of neuroinflammation.
Subcellular Translocation of Yorkie through the PRP4K–CRM1 Axis Regulates Antimicrobial Peptides Transcription and Defense against Bacterial Infection in Crab
Bacteria-induced yorkie translocated from the nuclei into the cytoplasm.
Interaction between yorkie and CRM1 is essential for its subcellular translocation.
PRP4K phosphorylates yorkie and promotes its interaction with CRM1.
Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression
Cancer cells upregulate surface MARCO expression on macrophages via STAT3 activation.
MARCO induces M2 polarization with increased expression of IL-10 and PD-L1.
MARCO ligation suppresses T cell response mainly by decreasing their proliferation.
IMMUNE SYSTEM DEVELOPMENT
Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells
Spi-C negatively regulates Rag1, Rag2, and Igκ transcription.
PU.1 positively regulates Rag1, Rag2, and Igκ transcription.
Spi-C and PU.1 both interact with a site in the Rag1 promoter.
Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells
Recent thymic emigrants transition into mature naive cells via a CD45RBint stage.
Immature naive T cells require Notch signals to undergo functional differentiation.
Immature naive T cells display a bias toward IL-17 production.
Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells
Mst1−/− promotes the differentiation and maturation of neutrophils from GMPs.
Glycolysis and SDH-mediated OXPHOS regulate the granulopoiesis initiated by MST1.
MST1-mTOR-HIF1α–mediated cell metabolism reprograms the differentiation of GMPs.
INFECTIOUS DISEASE AND HOST RESPONSE
C3/CD11b-Mediated Leishmania major Internalization by Neutrophils Induces Intraphagosomal NOX2-Mediated Respiratory Burst but Fails to Eliminate Parasites and Induces a State of Stalled Apoptosis
iC3b/CD11b receptor–mediated phagocytosis of Leishmania is proparasitic.
Leishmania internalization, not infection, induces phosphatidylserine expression.
Leishmania internalization induces a state of “stalled apoptosis” in neutrophils.
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L−CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
CCL28/CCR10 protects the vaginal mucosal from herpes infection and disease.
CCL28/CCR10 mobilizes memory CCR10+CD44+CD8+ T cells into the vaginal mucosa.
CCL28/CCR10 mobilizes memory CCR10+B220+CD27+ B cells into the vaginal mucosa.
INNATE IMMUNITY AND INFLAMMATION
METTL3-Mediated m6A Modification of TRIF and MyD88 mRNAs Suppresses Innate Immunity in Teleost Fish, Miichthys miiuy
m6A writer METTL3 expression increases when miiuy croaker is infected by pathogens.
The methylase activity of METTL3 inhibits innate immunity to infections.
METTL3 controls TRIF and MyD88 levels in a YTHDF2/3 reader–dependent manner.
Single-Nucleus Sequencing of Fat Body Reveals Distinct Metabolic and Immune Response Landscapes in Silkworm Larvae after Bombyx mori Nucleopolyhedrovirus Infection
The cellular map of the larval silkworm fat body was constructed.
Metabolic responses in fat body tend to be inhibited after BmNPV infection.
A robust immune response was induced in fat body cell subsets by BmNPV infection.
Proteogenomic and V(D)J Analysis of Human Decidual T Cells Highlights Unique Transcriptional Programming and Clonal Distribution
scRNA/CITE-seq results show that decidual T cells maintain a unique transcriptome.
Decidual T cells overexpress negative regulators of inflammatory pathways.
Specific decidual T cell clusters display lower clonotype diversity.
EXPRESSIONS OF CONCERN
On the cover: Representative bacterial stimulation–induced nucleocytoplasmic transport of yorkie (Yki). PRP4K phosphorylates the S26 amino acid residue of Yki, promotes its interaction with CRM1, leads to nuclear export of Yki, and results in a high level of antibacterial responses. Qin, Y., K. Zhao, K. Zhou, Z. Luo, X. Nan, Q. Wang, and W. Li. 2023. Subcellular translocation of yorkie through the PRP4K–CRM1 axis regulates antimicrobial peptides transcription and defense against bacterial infection in crab. J. Immunol. 211: 43–56.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkEditorial Board