Issues

The transcription factor Bhlhe40 is highly induced in NK cells during MCMV infection.

Bhlhe40 upregulation is driven by IL-12 via STAT4 binding of the Bhlhe40 promoter.

Bhlhe40 is critical for protection against infection by promoting IFN-γ production.

Anti-DNA autoantibody response in DNASE1L3-deficient mice requires TLR2.

Microbial products signal via TLR2 to elicit IL-6 secretion by B cells.

IL-15 priming of NK cells enables metabolic flexibility for IFN-γ production.

IL-15 priming alters the transcriptional response to activating receptor stimulation.

Myc marks NK cells capable of Ifng transcription, but is not required.

Depletion of NC-derived cells leads to reduction of noradrenaline.

NC-derived cells contribute to mesenchymal cells and sympathetic nerves in the adult thymus.

NC-derived cells within adult thymus regulate early T cell development.

Aged GC B cells can undergo positive selection in young mice upon immunization.

Aged GC B cells acquire high-affinity mutations postimmunization in young mice.

B cells from young mice have fewer high-affinity mutations in aged hosts.

Notopterol ameliorates ligature-induced periodontitis in mice.

Notopterol attenuates inflammatory response by inhibiting the NF-κB pathway.

Notopterol lowers ROS production via activation of the PI3K/Akt/Nrf2 pathway.

Host genotype alters immunological mechanisms of gammaherpesvirus infection control.

C57BL/6J mice expand Th CTL populations in response to chronic MHV-68 infection.

Superior control of MHV-68 viral load in PWD/PhJ mice is dependent on NK cells.

B. burgdorferi induces B-2 cells to continuously secrete passively protective IgM.

IgM suppresses B. burgdorferi burden in the blood, but not in tissues.

B. burgdorferi promotes enhanced IgM secretion after vaccination.

Anti-TLR4 mAb, a TLR4 blocker, or TLR4 deficiency ameliorated hepatitis.

Intrarectal inoculation of E. coli, as an extra source of LPS, exacerbates hepatitis.

The LPS–TLR4 pathway plays a pivotal role in hepatitis of MHV68-infected mice.

OxLDL accumulation in Mφs impairs LPS-induced HIF-1α–dependent glycolysis.

OxLDL accumulation in Mφs enhances LPS-induced Nrf2-dependent antioxidative response.

Competition for NADPH between HIF-1 and Nrf2 processes fine-tunes inflammation.

AlphaFold was used to predict 222 new (to our knowledge) 3D high-resolution atomic structures of Ab chains.

Low accuracy was observed in the prediction of HC-CDR3 and the elbow angles.

Predicting Ab–Ag complexes and epitope mapping using AlphaFold-Multimer was limited.

Low-dose intratumoral GM-CSF reduces breast tumor hypoxia and normalizes vasculature.

Low-dose GM-CSF priming sensitizes “cold” PyMT tumors to anti-PD1 immunotherapy.

The GM-CSF effects on TAM vary between “hot” and cold TNBC models.