IMMUNOLOGY NOTES AND RESOURCES
PILLARS OF IMMUNOLOGY
CLINICAL AND HUMAN IMMUNOLOGY
Third and Fourth Vaccine Doses Broaden and Prolong Immunity to SARS-CoV-2 in Adult Patients with Immune-Mediated Inflammatory Diseases
Anti-TNF–treated patients with IBD have reduced Ab responses over four vaccine doses.
Third and fourth doses increase the breadth and durability of neutralization responses.
T cell IL-4 levels increase with successive vaccine doses.
IL-2/STAT5 signaling induces Eos expression.
Eos promotes TH2 cell programming.
Eos interacts with and propagates the tyrosine phosphorylation of STAT5.
Leukocyte-mediated clustering of ICAM-1 recruits CD44.
CD44 binds hyaluronan on the endothelial surface.
Hyaluronan presents chemokines to mediate T cell extravasation.
IMMUNOTHERAPY AND VACCINES
Helminth (Heligmosomoides polygyrus bakeri) infection reduced vaccine-induced Ab responses in mice.
Hpb infection promoted vaccine-specific IL-10+ and IL-4+ CD4+ T cells in MLNs.
Vaccine-specific CD4+ T cells from Hpb-infected mice blunted vaccine Ab responses.
A bispecific Ab format for complement activation was developed.
Abs recruit C1q to a selected target.
BiCE shows potent complement-dependent killing of specific target cells.
INFECTIOUS DISEASE AND HOST RESPONSE
Epigenetic Regulation of Leukocyte Inflammatory Mediator Production Dictates Staphylococcus aureus Craniotomy Infection Outcome
HDAC/BET inhibition selectively attenuates inflammatory mediator production.
Other phagocyte antimicrobial properties are not affected by Class I HDACi/BETi.
HDAC and BET inhibition increases S. aureus burden during craniotomy infection.
HIV infection increases microglial survival through TREM1 expression.
HIV Tat increases the expression of TREM1 in human microglia.
Tat-mediated TREM1 expression is dependent on TLR4 signaling and PGE2.
INNATE IMMUNITY AND INFLAMMATION
FcRγ− NK Cell Induction by Specific Cytomegalovirus and Expansion by Subclinical Viral Infections in Rhesus Macaques
FcRγ− NK cells resembling human g-NK cells are identified in RhCMV-infected macaques.
Induction of macaque adaptive FcRγ− NK cells is RhCMV strain specific.
Coinfection by non-RhCMV viruses expands the adaptive FcRγ− NK cell pool.
The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms
Mini-FH inhibits ligature-induced periodontitis (LIP) in wild-type mice.
Mini-FH suppresses LIP also in C3-deficient mice in a CD11b-dependent manner.
Mini-FH inhibition of LIP is both complement dependent and independent.
Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate–Cholesterol–PI(4,5)P2 Pathway
Sfxn5 is important for neutrophil spreading and migration.
Sfxn5 regulates neutrophil actin polymerization.
Sfxn5 modulates neutrophil spreading via a citrate–cholesterol–PI(4,5)P2 axis.
IL-27 limits HSV-1 shedding from the cornea and suppresses HSK progression.
IL-27 modulates APC-mediated HSV-1 Ag presentation to regulate Th1 responses.
IL-27 promotes macrophage survival and IFN-β responses after HSV-1 infection.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Human lung-resident B cells are phenotypically distinct from peripheral blood B cells.
Lung-resident B cells have lower specific diversity than do peripheral blood B cells.
Lung-resident B cells are genetically distinct from peripheral blood B cells.
Activin A–Expressing Polymorphonuclear Myeloid-Derived Suppressor Cells Infiltrate Skeletal and Cardiac Muscle and Promote Cancer Cachexia
CD244+ PMN-MDSCs expand and drive cancer-cachectic development in the LLC model.
PMN-MDSC–driven cachectic wasting is not influenced by IL-6, TNF-α, or Arg1.
PMN-MDSCs are active producers of activin A, which drives muscle wasting.
On the cover: Energy landscapes describe catch bonds in interfaces between TCRs and their ligands. For a catch bond, mechanical force shifts the complex into a more stable state with a higher barrier for dissociation. The opposite, a slip bond, results when forces shift the complex into a less stable state. Ayres, C. M., S. A. Corcelli, and B. M. Baker. 2023. The energetic landscape of catch bonds in TCR interfaces. J. Immunol. 211: 325–332.
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