ALLERGY AND OTHER HYPERSENSITIVITIES
FcεRI-mediated mast cell function is susceptible to isoprenylation inhibitors.
K-Ras is a critical component of FcεRI-mediated mast cell activation.
Targeting isoprenylation can suppress allergic inflammation in vivo.
CLINICAL AND HUMAN IMMUNOLOGY
NK Cells from Human Cytomegalovirus–Seropositive Individuals Have a Distinct Metabolic Profile That Correlates with Elevated mTOR Signaling
NK cells from HCMV+ individuals have elevated levels of glycolytic metabolites.
NK cells from HCMV+ individuals exhibit very high levels of deoxyribonucleotides.
Adaptive NK cells exhibit more robust mTORC1 activation in response to activation.
CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation
CD103 restrains Treg migration in inflamed skin when E-cadherin is upregulated.
CD103 supports interactions of Tregs with CD11c-expressing cells in inflamed skin.
CD103 inhibition increases inflammation in contact hypersensitivity.
Distinct glutamine inhibition strategies cause unique changes to CD8 T cell function.
T cell metabolism compensates according to how glutamine metabolism is targeted.
Timing and strategy for use of glutamine-targeting agents modify T cell outcomes.
pDCs cooperate with B cells through the production of IFN-I and CXCL10.
pDCs enhance the T-independent B response through a p38 MAPK–STAT1 axis.
pDCs enhance TLR-stimulated autoantibody production in FO B and MZ B cells.
The NF-κB/Relish Activates miR-308 to Negatively Regulate Imd Pathway Immune Signaling in Drosophila
miR-308 targets Tab2 to negatively regulate the immune response.
Relish binds the promoter and activates the expression of miR-308.
The Relish–miR-308–Tab2 axis is critical for immune homeostasis in the Drosophila Imd pathway.
INFECTIOUS DISEASE AND HOST RESPONSE
The Endogenous Retinoic Acid Receptor Pathway Is Exploited by Mycobacterium tuberculosis during Infection, Both In Vitro and In Vivo
M. tuberculosis induces RARE genes by human monocytes.
M. tuberculosis metabolizes serum components and activates RAR pathway.
BMS493, a specific pan-RAR inverse agonist, inhibits M. tuberculosis growth in mice.
Human dendritic cells present Borrelia-derived peptides on HLA-DR molecules.
Borrelia-exposed mo-DCs undergo profound and unique molecular and cellular changes.
Borrelia-exposed mo-DCs may have unique immunoregulatory properties.
Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation
There is a role for Rora in Th2 cell development.
Rora CD4-deficient mice expel worms and develop allergic lung inflammation.
INNATE IMMUNITY AND INFLAMMATION
Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation
Granzyme K expression on innate lymphocytes is associated with a memory-like phenotype.
Granzyme K+ cells are enriched in nonlymphoid tissues and express CCR5.
Granzyme K+ cells are enriched in tumors and produce IFN-γ but not IL-17a.
Histones produce acute thromboinflammatory responses in vascular endothelium.
Suramin protects small blood vessels from histone-induced damage.
Activation Mechanism of CcGSDMEb-1/2 and Regulation for Bacterial Clearance in Common Carp (Cyprinus carpio)
CcGSDMEb-1/2 were cleaved only by CcCaspase-1b.
CcGSDMEb-1/2 exerted toxicity to cells through its N-terminal domains.
CcGSDMEb-1/2 could regulate the secretion of CcIL-1β and the bacterial clearance.
Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile
Mass cytometry analysis reveals intratumor immune changes caused by anti-CCR8 therapy.
CCR8+ Treg depletion alters intratumor CD8+ T cell activation and exhaustion status.
CD8+ T cell exhaustion is associated with CCR8+ Treg infiltration in human tumors.
G Protein–Coupled Receptor 56 Characterizes CTLs and Reflects the Progression of Lung Cancer Patients
GPR56 and granzyme B were significantly coexpressed in circulating T cells.
Increased circulating GPR56+ T cells were related to lung cancer progression.
Anti-GPR56 stimulation of GPR56+ T cells significantly upregulated granzyme B.
IR-induced immunoproteasomes and APM correlate with tumor T cell infiltration.
Forcing LMP7 expression in an LMP7-negative tumor generates immune rejection.
The irradiation effect on the APM is NF-κB dependent.
On the cover: CD103 retains regulatory T cells (Tregs) in skin, but how? Intravital imaging was used to investigate the role of CD103 in skin Treg behavior. The image shows extensive Treg migration after CD103 inhibition 48 h after induction of contact hypersensitivity, demonstrating a role for CD103 as a brake on Treg migration. Norman, M. U., Z. Chow, P. Hall, A. C. Le, K. M. O’Sullivan, S. L. Snelgrove, J. A. Deane, and M. J. Hickey. 2023. CD103 regulates dermal regulatory T cell motility and interactions with CD11c-expressing leukocytes to control skin inflammation. J. Immunol. 211: 551–562.
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