Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras–MAPK Signaling
Rasgrp1 is necessary for TCR/CD28-induced Ras–ERK in murine peripheral CD4+ T cells.
TCR/CD28-induced CD4+ T cell IL-2 and IL-2R expression is dependent on Rasgrp1.
TCR/CD28-induced CD4+ T cell proliferation is severely impacted by Rasgrp1 deficiency.
ANTIGEN RECOGNITION AND RESPONSES
Very few B cells can adhere to activated human endothelial cells under flow.
Chemokines and BCR signals can trigger morphologically distinct mechanisms of TEM.
Furthermore, BCR signals select a rare innate-like memory subset.
α-d-Glucose-1,6-Biphosphate Induces Dendritic Cell Homing to Enhance the Antitumor Effect of Neoantigen Vaccines
α-d-Glu induces DC homing to improve the antitumor effect of neoantigens vaccines.
α-d-Glu promotes DC migration comparable with PGE2.
α-d-Glu promotes DC migration by inhibiting microRNA10a-5p and activating Erk1/2.
Proteolipid Protein–Induced Mouse Model of Multiple Sclerosis Requires B Cell–Mediated Antigen Presentation
B cell Ag presentation to CD4s via MHCII is required for PLPECD EAE disease.
B cells promote CD4 proliferation, cytokine production, and pathogenicity.
PLPECD EAE is susceptible to B cell depletion therapy.
DNAM-1 Immunoreceptor Protects Mice from Concanavalin A–Induced Acute Liver Injury by Reducing Neutrophil Infiltration
DNAM-1 protects mice from Con A–induced acute liver injury.
DNAM-1 reduces neutrophil infiltration in Con A–induced acute liver injury.
CD155 on hepatocytes inhibits CXCL1 production in Con A–induced acute liver injury.
An Atlas of Grass Carp IgM+ B Cells in Homeostasis and Bacterial Infection Helps to Reveal the Unique Heterogeneity of B Cells in Early Vertebrates
Three functional IgMs are present in grass carp.
The landscape of grass carp IgM+ B cells is revealed by scRNA-seq.
Single IgM+ B cells express multiple Igμ genes with distinct VHDJH recombination patterns.
IMMUNOTHERAPY AND VACCINES
The SD1 domain is essential for the SARS-CoV-2 RBD to elicit immunogenicity.
Addition of human Fc receptor to RBDSD1 (RBDSD1Fc) enhances immunogenicity.
An RBDSD1Fc subunit vaccine protects hACE2 knock-in mice against SARS-CoV-2 challenge.
INFECTIOUS DISEASE AND HOST RESPONSE
B. burgdorferi Arp152–166-containing MHC II tetramers identify Arp-specific CD4 T cells.
Labeled tetramerized Arp identifies small numbers of Arp B cells after B. burgdorferi infection.
Data indicate a failure to maintain but not to induce an Arp response after infection.
INNATE IMMUNITY AND INFLAMMATION
Liver X Receptor LXRα Promotes Grass Carp Reovirus Infection by Attenuating IRF3–CBP Interaction and Inhibiting RLR Antiviral Signaling
gcLXRα promotes the replication and infection of GCRV.
gcLXRα heterodimerizes with RXRga and RXRgb.
gcLXRα impairs formation of the IRF3/CBP transcription complex.
The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1
Host RTCB is significantly downregulated during influenza A viral infection.
Influenza A virus propagation is affected by RTCB knockout.
RTCB competitively binds DDX1, attenuating its association with DDX21.
4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2
4-OI and DMF induce annexin A1 secretion in LPS-stimulated macrophages.
The induction of annexin A1 secretion by 4-OI and DMF requires ABCA1 and NRF2.
4-OI induces annexin A1 secretion in vivo.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A nonrearranging Ig gene, UrIg, is discovered that maps to the shark MHC.
UrIg is a four-domain dimer expressed by the liver, and the protein is found in the ECM.
UrIg may predate invasion of an Ig superfamily gene by the RAG transposon.
High IL-1β levels in the intestine are associated with an increased survival time.
Intestinal IL-1β is associated with a reduced intestinal viral load.
Intestinal IL-1β is associated with increased levels of intestinal type I IFNs.
On the cover: Double immunofluorescent staining of a nurse shark kidney section. UrIg is produced by the liver and transported to tissues in a so-far unidentified manner, and it associates with extracellular matrix. UrIg (red) is bound to collagen matrix (green) at a perpendicular angle. Triple collagen helix is visualized with Alexa 488–conjugated CNA35. Flajnik, M. F., R. Stanfield, E. N. Pokidysheva, S. P. Boudko, I. Wilson, and Y. Ohta. 2023. An ancient MHC-linked gene encodes a nonrearranging shark antibody, UrIg, convergent with IgG. J. Immunol. 211: 1042–1051.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkEditorial Board