Issues

Our results suggest a potential risk factor of SEB in food allergy.

Coexposure to SEB could aggravate hypothermia and diarrhea induced by OVA allergy.

The dose of SEB plays a dominant role in the direction of Th cell differentiation.

Tapasin alters HLA class I peptide binding preferences at peptide C-termini.

Tapasin-independent assembly expands affinity range of peptide–HLA class I binding.

Reduction of IRF5 expression after disease onset reduces disease in murine lupus.

Reduction of IRF5 expression impacts systemic and end-organ pathogenic pathways.

Neonatal, but not adult, immunization with group A Streptococcus delays T1D in NOD mice.

Immunization enriches B1 cells reactive to apoptotic β cells in the pancreas.

These expanded B1 cells delay T1D progression by multiple immunological mechanisms.

Ab-secreting B cell expansion is shown in the cerebrospinal fluid of pediatric NMDAR-AE patients.

V_H2 overuse in a treatment-refractory pediatric NMDAR-AE case is described.

A CDR3 motif of NR1-binding V_H2-70⁺ B cells is identified.

Jagged1 is an RBP-J target, and TNF activates the RBP-J/Jagged1 axis in macrophages.

TNF-induced Jagged1 is a feedback inhibitor of inflammatory osteoclastogenesis.

RANKL does not induce Jagged1, which does not affect RANKL-induced osteoclastogenesis.

TRPML1-derived lysosomal calcium regulates mitochondrial organization and fitness.

Loss of the lysosomal calcium channel TRPML1 leads to mitochondrial dysfunction.

TRPML1 activity modulates autophagy induction, a prerequisite for mitophagy.

Foxp3 TSDR demethylation is governed by autocrine C3ar1/C5ar1 signaling in Tregs.

Treg generation under in vivo conditions is required for TSDR demethylation.

CD160 is intrinsically required for virus-induced CD8⁺ T cell memory formation.

4-1BB is a major downstream target of CD160 in regulating CD8⁺ T cell activation.

Signaling and metabolic pathways differ in thymic versus liver and spleen iNKT1 cells.

TGF-β promotes the postselection maturation of thymic iNKT1 cells.

TGF-β controls TGF-β and cytokine signaling gene signatures in thymic iNKT1 cells.

ManLAM suppresses productive activation of human CD4⁺ T cells.

ManLAM can be acquired by CD4⁺ T cells from BCG-infected monocytes in cocultures.

ManLAM disrupts the integrity of the CD4⁺ T cell–macrophage immunological synapse.

IFN-γ delays Pneumocystis clearance by suppressing the pulmonary Th17 response.

IFN-γ limits PcP-related immunopathogenesis by restraining lung inflammation.

SLC25A23 can interfere with the binding of Trim31 to MAVS.

SLC25A23 attenuates type I IFN antiviral immunity.

SLC25A23 knockdown mice are more resistant to RNA virus infection.

DRD1 is higher expressed on ILC2s in the TME than in the lung.

DRD1 deficiency curtails tumor growth via boosting ILC2 responses in mice.

Activating the DRD1 signal impairs the ILC2 response, along with bluntness of tumor control.

To our knowledge, we established a successful novel humanized GVL model system.

AML induced T cell depletion and T cell exhaustion in the humanized GVL model.

Triple blockade of PD-1, TIGIT, and TIM-3 effectively reduced leukemia burden.