PILLARS OF IMMUNOLOGY
ALLERGY AND OTHER HYPERSENSITIVITIES
Our results suggest a potential risk factor of SEB in food allergy.
Coexposure to SEB could aggravate hypothermia and diarrhea induced by OVA allergy.
The dose of SEB plays a dominant role in the direction of Th cell differentiation.
ANTIGEN RECOGNITION AND RESPONSES
Mass Spectrometric Profiling of HLA-B44 Peptidomes Provides Evidence for Tapasin-Mediated Tryptophan Editing
Tapasin alters HLA class I peptide binding preferences at peptide C-termini.
Tapasin-independent assembly expands affinity range of peptide–HLA class I binding.
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
Reduction of IRF5 expression after disease onset reduces disease in murine lupus.
Reduction of IRF5 expression impacts systemic and end-organ pathogenic pathways.
B-1 B Cell–Derived Natural Antibodies against N-Acetyl-d-Glucosamine Suppress Autoimmune Diabetes Pathogenesis
Neonatal, but not adult, immunization with group A Streptococcus delays T1D in NOD mice.
Immunization enriches B1 cells reactive to apoptotic β cells in the pancreas.
These expanded B1 cells delay T1D progression by multiple immunological mechanisms.
CLINICAL AND HUMAN IMMUNOLOGY
VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis
Ab-secreting B cell expansion is shown in the cerebrospinal fluid of pediatric NMDAR-AE patients.
VH2 overuse in a treatment-refractory pediatric NMDAR-AE case is described.
A CDR3 motif of NR1-binding VH2-70+ B cells is identified.
Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis
Jagged1 is an RBP-J target, and TNF activates the RBP-J/Jagged1 axis in macrophages.
TNF-induced Jagged1 is a feedback inhibitor of inflammatory osteoclastogenesis.
RANKL does not induce Jagged1, which does not affect RANKL-induced osteoclastogenesis.
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
TRPML1-derived lysosomal calcium regulates mitochondrial organization and fitness.
Loss of the lysosomal calcium channel TRPML1 leads to mitochondrial dysfunction.
TRPML1 activity modulates autophagy induction, a prerequisite for mitophagy.
Disabled C3ar1/C5ar1 Signaling in Foxp3+ T Regulatory Cells Leads to TSDR Demethylation and Long-Term Stability
Foxp3 TSDR demethylation is governed by autocrine C3ar1/C5ar1 signaling in Tregs.
Treg generation under in vivo conditions is required for TSDR demethylation.
CD160 is intrinsically required for virus-induced CD8+ T cell memory formation.
4-1BB is a major downstream target of CD160 in regulating CD8+ T cell activation.
IMMUNE SYSTEM DEVELOPMENT
TGF-β Promotes the Postselection Thymic Development and Peripheral Function of IFN-γ–Producing Invariant NKT cells
Signaling and metabolic pathways differ in thymic versus liver and spleen iNKT1 cells.
TGF-β promotes the postselection maturation of thymic iNKT1 cells.
TGF-β controls TGF-β and cytokine signaling gene signatures in thymic iNKT1 cells.
INFECTIOUS DISEASE AND HOST RESPONSE
Impact of Mycobacterium tuberculosis Glycolipids on the CD4+ T Cell–Macrophage Immunological Synapse
ManLAM suppresses productive activation of human CD4+ T cells.
ManLAM can be acquired by CD4+ T cells from BCG-infected monocytes in cocultures.
ManLAM disrupts the integrity of the CD4+ T cell–macrophage immunological synapse.
IFN-γ delays Pneumocystis clearance by suppressing the pulmonary Th17 response.
IFN-γ limits PcP-related immunopathogenesis by restraining lung inflammation.
INNATE IMMUNITY AND INFLAMMATION
Genome-Wide CRISPR/Cas9 Screening Identifies That Mitochondrial Solute Carrier SLC25A23 Attenuates Type I IFN Antiviral Immunity via Interfering with MAVS Aggregation
SLC25A23 can interfere with the binding of Trim31 to MAVS.
SLC25A23 attenuates type I IFN antiviral immunity.
SLC25A23 knockdown mice are more resistant to RNA virus infection.
DRD1 is higher expressed on ILC2s in the TME than in the lung.
DRD1 deficiency curtails tumor growth via boosting ILC2 responses in mice.
Activating the DRD1 signal impairs the ILC2 response, along with bluntness of tumor control.
NOVEL IMMUNOLOGICAL METHODS
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
To our knowledge, we established a successful novel humanized GVL model system.
AML induced T cell depletion and T cell exhaustion in the humanized GVL model.
Triple blockade of PD-1, TIGIT, and TIM-3 effectively reduced leukemia burden.
On the cover: Three-dimensional reconstruction of an NK92 cell deficient in lysosomal TRPML1 channel depicting its fragmented mitochondrial network color-coded in rainbow scale with the largest mitochondrial network shown as red. Loss of TRPML1 leads to accumulation of dysfunctional mitochondria. Clement, D., E. K. Szabo, S. Z. Krokeide, M. T. Wiiger, M. Vincenti, D. Palacios, Y.-T. Chang, C. Grimm, S. Patel, H. Stenmark, A. Brech, R. K. Majhi, and K.-J. Malmberg. 2023. The lysosomal calcium channel TRPML1 maintains mitochondrial fitness in NK cells through interorganelle cross-talk. J. Immunol. 211: 1348–1358.
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