Issues

A single respiratory infection induces lifelong mediastinal lymph node enlargement.

Enlarged lymph nodes enhance immune surveillance and better support memory CD8⁺ T cell formation following new unrelated infections.

Lung infection experience can moderate pathogenicity of subsequent respiratory infections.

A subset of murine Tregs expresses sialyl Lewis X (sLe^x) glycans.

Murine sLe^x+ Tregs are activated and proliferative subpopulation.

Murine sLe^x+ Tregs show stronger suppressive activity compared with sLe^x− Tregs.

TLRs treatment induces signalosome-independent alternate pathway for BCR signaling.

TLRs treatment phosphorylate and activates tyrosine kinases.

PKCδ phosphorylation occurs in the cytosol through the TLRs induced alternate pathway.

We used the EAE model to develop imaging and treatment for MS.

PET/CT showed binding of anti–PD-1 Ab to activated T cells.

¹⁷⁷Lu–anti–PD-1 Ab killed activated T cells and reduced disease progression.

Reducing Ag exposure limits generation of cytotoxic TIM3⁺ autoreactive T cells.

Widespread Ag expression drives autoreactive CD8⁺ T cell dysfunction.

Puerarin amelioration of Hashimoto’s thyroiditis was macrophage-dependent.

Puerarin treatment exerted anti-inflammatory effects by promoting polarisation of M2 macrophages in HT.

Puerarin treatment inhibited pyroptosis.

αvβ3 negatively regulates TLR7 and TLR9 signaling in pDCs.

αv or β3 deletion from pDCs results in increased IFN-I production.

Mice lacking αvβ3 in pDCs develop accelerated TLR7-driven autoimmunity.

scRNA-seq analysis predicts interactions between NK cells and monocytes in COVID-19.

Monocytes from COVID-19 donors induce activation and proliferation in healthy NK cells.

CD56^bright NK cells are activated by monocyte-derived soluble proinflammatory factors.

Activated MAIT cells increase iron uptake via CD71.

MAIT cell metabolism and functionality are dependent on a CD71-iron axis.

Zfp335 deficiency impairs effector CD4⁺ Th1 cell differentiation and survival.

Zfp335 controls CD4⁺ Th1 cell generation via Lmna expression.

CRISPR-Cas9 successfully knocked down target molecules in primary human CD8 T cells

IFN-γ, GzmB, PRF1, and LYST are required for CD8 T cell–mediated suppressive ability

Zebrafish thymic involution timing and rising B:T cell ratios resemble those of humans.

RNA-seq of four new dual-transgenic lines reveals distinct T and B cell populations.

Zebrafish represent a new involution model with conserved properties to mammals.

Transgenic chickens have been engineered to produce chicken VH sdAbs.

These chickens raise robust immune responses upon immunization.

sdAbs from the birds show favorable biophysical properties and antigen recognition.

Genomic assemblies of MCM KIR and NKG2 haplotypes were produced from long reads.

A prototype workflow of accurate genotyping of MCM KIR and NKG2 was developed from exome data.

BHLHE40 promotes GM-CSF–mediated proinflammatory responses.

BHLHE40 regulates inflammation via IL-10–dependent and –independent mechanisms.

Enterovirus 71 activates plasmacytoid dendritic cell–dependent PSGL-1 binding.

Enterovirus 71 was found to activate pDCs independent of productive infection.

LGP2 binds PGN and negatively regulates the NOD2–RIP2 axis to promote bacteria escape.

LGP2 binds PGN via the EEK motif in the Cyprinidae and Xenocyprididae families.

Polypeptide antibiotics promote infiltration of macrophages to kidney.

The NLRP3 inflammasome is responsible for polypeptide antibiotic-induced acute renal failure.

THEMIS2 attenuates effector functions of human and mouse NK cells.

THEMIS2 binds to GRB2 and phosphatases.

Deficiency of THEMIS2 enhances antitumor activity of NK cells.

Bhlhe40 positively and negatively regulates Th1 and Tfh differentiation, respectively.

Bhlhe40 directly binds to Th1 and Tfh genes to facilitate their expression.

MyD88 is required in myeloid cells for colon IEL recruitment to the epithelium.

Bacteria induce MyD88-dependent S1P production in myeloid cells.

Loss of IELs in a model of chronic bowel inflammation ameliorates disease severity.