TOP READS
BRIEF REVIEWS
Metabolic Plasticity of Regulatory T Cells in Health and Autoimmunity
ALLERGY AND OTHER HYPERSENSITIVITIES
Single-Cell Analysis Uncovers Striking Cellular Heterogeneity of Lung-Infiltrating Regulatory T Cells during Eosinophilic versus Neutrophilic Allergic Airway Inflammation
Lung infiltrating Tregs are highly heterogeneous during different allergic inflammation.
Tregs expressing ST2 are associated with eosinophilic inflammation.
ST2 deficiency in Tregs does not influence the development of eosinophilic inflammation.
IMMUNE REGULATION
Hyperosmotic Stress Induces Inflammation and Excessive Th17 Response to Blunt T-Cell Immunity in Tilapia
Hypertonic stress induces excessive Th17 response and impairs T-cell response.
Tilapia T cells use the ROS–p38–MK2 axis to sense the hypertonic stress.
Polyclonally Derived Alloantigen-Specific T Regulatory Cells Exhibit Target-Specific Suppression and Capture MHC Class II from Dendritic Cells
Allo-iTreg suppression is nonspecific in vitro but antigen-specific in vivo.
Allo-iTregs specifically capture their target alloantigen from the DC surface.
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization
TGF-β1/IL-15–induced NK-like cells expressed markers of inhibitory CD56+ ILCs.
Ascites-derived TGF-β induced CD103+CD49a+ NK-like cells.
TGF-β1/IL-15–induced NK-like cells suppressed autologous CD4+ T cells in vitro.
IMMUNE SYSTEM DEVELOPMENT
Glycan-Reactive Innate-like B Cells and Developmental Checkpoints
GlcNAc epitopes are found on multiple microorganisms and self-antigens.
Expression of anti-GlcNAc-reactive BCRs promotes development of innate-like B cells.
GlcNAc-specific BCRs disadvantage B cells at peripheral tolerance checkpoints.
INFECTIOUS DISEASE AND HOST RESPONSE
A Significant Contribution of the Classical Pathway of Complement in SARS-CoV-2 Neutralization of Convalescent and Vaccinee Sera
SARS-CoV-2 neutralization titers were highest in convalescent severe patients.
Inhibiting the complement pathway halved neutralization titers in all participants.
Complement-mediated neutralization is driven mainly through the classical pathway.
INNATE IMMUNITY AND INFLAMMATION
IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages
IRF7 promotes C. albicans infection.
IRF7 inhibits macrophage phagocytosis by suppressing CD209.
IRF7 inhibits macrophage killing function by suppressing p53-AMPK-mTOR mediated autophagy.
Nucleic Acid Sensing by STING Induces an IFN-like Antiviral Response in a Marine Invertebrate
LvSTING defends against DNA virus infection.
LvSTING interacts with both dsDNA and CDNs.
LvSTING senses dsDNA from viral infection to trigger the downstream STING–IKKε–IRF–Vago antiviral axis.
MUCOSAL IMMUNOLOGY
The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast–Monocyte Interactions
TNFSF12/TWEAK induces an inflammatory profile on colonic fibroblasts.
TWEAK-treated fibroblasts promote monocyte adhesion and inflammatory polarization.
Inhibition of the noncanonical NF-κB pathway partially blocks this interaction.
TRANSPLANTATION
Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation
Islets engineered with SA-TM and SA-CD47 proteins maintain viability and function.
SA-TM and SA-CD47 proteins mitigate instant blood-mediated inflammatory reactions.
Islets engineered with TM and CD47 proteins show improved intraportal engraftment.
Separating the Wheat from the Chaff among HLA-DQ Eplets
This study validate HLA-DQ eplets not fully verified in Epregistry.
Absorption of patient sera on two types of cells was performed to precisely verify eplet.
Single HLA-DQ clone were raised by transfection in a murine cell line.
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Cover Image
Cover Image
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On the cover: To determine whether alloantigen-specific iTreg captured their target alloantigen from DC, iTreg were cultured with DC. A gating strategy was devised that allowed identification of the iTreg in the co-culture as Thy1.1+ CD45.1− CD45.2+ Foxp3+ and DCs in the culture as CD45.1+ Thy1.1−. Oya Y., Y. Tanaka, T. Nakazawa, R. Matsumura, D. D. Glass, H. Nakajima, and E. M. Shevach. Polyclonally-derived alloantigen-specific T Regulatory cells exhibit target-specific suppression and capture MHC class II from dendritic cells. J. Immunol. 212: 1891–1903.
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