Issues

M.tb induces AIM2 expression in a PPARγ-dependent and M.tb ESX-1–independent manner.

PPARγ, not AIM2, is important for M.tb-induced IL-1β release in human macrophages.

NLRP3 colocalizes with M.tb and is important for IL-1β release in human macrophages.

SCFAs suppress IgE-mediated activation of mast cells in vivo and in vitro.

GPR109A, PGE₂, EP3, and HDACi are involved in antiallergic effects of SCFAs.

Elevation in NMOSD and MG CD56^dimCD16^dim/− NK cells suggests prior ADCC activity.

CD56^dimCD16^dim/− NK cells exhibit HLA-DR, trogocytosis, and reduced cytotoxicity.

MOGAD NK cells do not exhibit functional, phenotypic, or transcriptional changes.

USP13 promotes SCRV replication by inhibiting IFN responses.

USP13 promotes the autophagic degradation of MAVS.

USP13 recruits MARCH8 to catalyze MAVS for autophagic degradation.

Cmv5^s, comprising multiple MHC loci, dominantly impedes NK cell MCMV control.

Cmv5^s NK cells selectively display high Tim-3 and Lag-3 during MCMV infection.

Cmv5^s splenic tissue damage precedes divergence in viral load and NK cell phenotype.

SARS-CoV-2–specific CD8⁺ T cells are frequently detected in convalescent donors.

Allogeneic plasmacytoid cell line expands specific SARS-CoV-2 CD8⁺ T cells in vitro.

TCR sequencing for two T cell clones that target highly immunogenic epitopes.

Neonatal and adult CD8⁺ T cells adopt different fates during chronic infection.

Neonatal CD8⁺ T cells retain their effector bias and limit early viral replication.

Adult CD8⁺ T cells preferentially become exhausted and are less protective.

Reduced miR-345-3p levels boost inflammation in a rat IAFF model.

miR-345-3p deletion hinders macrophage polarization.

miR-345-3p inhibits MAP3K1/NF-κB, aiding M1 to M2 macrophage shift.

TLR5M and TLR5S synergistically sense flagellin in the early endosome in lamprey.

N-glycosylation N239 switches the ligand-binding and immune response for TLR5M/TLR5S.

TLR5M and TLR5S contain complex-type N-glycan, but only the high-mannose type for TLR5M.

The KIR2DS1 and KIR2DL1-C245 receptors dominantly repress NK cell ADCC.

Education by inhibitory KIR does not enhance the ADCC capacity of NK cells.

NKG2A expression on NK cells consistently associates with superior ADCC.

Alcohol combined with burn injury decreases miR-146a in small intestinal epithelial cells.

Reduced miR-146a promotes intestinal inflammation after alcohol and burn injury.

Antileishmanials modulate transcriptomic profiles of inflammation and skin remodeling.

Sustained inflammation and impaired tissue remodeling lead to CL treatment failure.

Major transcriptional changes in CL lesions occur at 10 days of treatment.

A predictive model of vaccine reactogenicity using in vitro assay data is presented.

A subset of tested biomarkers had higher predictive importance for adverse event risk.

FMR1NB is a (to our knowledge) novel target for CAR against lung cancer.

2DG makes T cells resistant to immune-inhibitory molecules.

2DG-treated T cells augment anti–lung cancer cytotoxicity of anti-FMR1NB CAR.