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J Immunol (2024) 212 (7): 1041.


J Immunol (2024) 212 (7): 1043–1050.
J Immunol (2024) 212 (7): 1051–1061.


J Immunol (2024) 212 (7): 1063–1068.

  • Canonical autophagy drives TAP-independent Ag cross-presentation.

  • LC3A/B-positive vesicles associate with the phagosome.

  • Proteasomes localize within the lumen of LC3A vesicles associated with phagosomes.

J Immunol (2024) 212 (7): 1069–1074.

  • Hypoxia impairs the activity of the epigenetic regulator UTX in CD4+ T cells.

  • UTX impairment protects against colonic inflammation in an IBD mouse model.

  • UTX loss downregulates inflammatory Th1 and increases suppressive Treg responses.

J Immunol (2024) 212 (7): 1075–1080.

  • Normal and malignant B cells lacking CD53 have impaired CXCL12-directed migration.

  • CD53 is a novel binding partner of CXCR4 in B cells.

  • CD53 promotes CXCL12/CXCR4 signaling and marrow homing in B cells.


J Immunol (2024) 212 (7): 1081–1093.

  • Fosl2 loss skews HSCs towards myeloid cell differentiation.

  • Fosl2 loss induces osteopetrosis in mice, causing bone marrow failure.

J Immunol (2024) 212 (7): 1094–1104.

  • The initial pathology of T1D is located outside the islet basement membrane.

  • A postcapillary venule–associated cell population expresses MHC class II molecules.

  • An extraislet tertiary lymphoid structure is necessary for progression of disease.


J Immunol (2024) 212 (7): 1105–1112.

  • COVID-19 presents low percentages of perforin-expressing NK cells.

  • This was not linked to disease severity but anticorrelated with NK degranulation.

  • A primary perforin deficiency does not seem to be a driver of COVID-19.


J Immunol (2024) 212 (7): 1113–1128.

  • CTLA-4 suppresses T cell activation, proliferation, and effector function of tilapia.

  • Tilapia CTLA-4 competes with CD28 for B7 binding.

  • CTLA-4 inhibits mTORC1/c-Myc axis–controlled T cell glycolysis and immunity.

J Immunol (2024) 212 (7): 1129–1141.

  • Eos positively regulates cytotoxic programming in CD4+ T cells.

  • Eos promotes IL-2 and IL-15 cytokine receptor expression.

  • Aiolos antagonizes STAT5-dependent induction of Eos expression.

J Immunol (2024) 212 (7): 1142–1149.

  • Disabling CD55 globally accelerates the growth of multiple cell types.

  • Potentiated C3ar1/C5ar1 signaling integrates with the signaling of receptor RTKs.

J Immunol (2024) 212 (7): 1150–1160.

  • DNA-reactive B cells require CD40 signaling to mount an autoantibody response.

  • Bystander CD4 T cells can provide T cell help to support an autoantibody response.

  • Enhanced PI3K signaling makes autoreactive B cells receptive to bystander T cell help.


J Immunol (2024) 212 (7): 1161–1171.

  • T. gondii infection induces IL-1β release from human peripheral blood monocytes.

  • Caspase-8 is not required for IL-1β cleavage but is critical for IL-1β release.

  • IL-1β is released via a pathway that is independent of cell death, GSDME, or ATG7.


J Immunol (2024) 212 (7): 1172–1177.

  • This study highlights a unique C1s/MASP-2 interaction with the vWF domain of C2.

  • This insight reveals a previously unexplored aspect of complement activation

J Immunol (2024) 212 (7): 1178–1187.

  • CLEC-1 represses CXCL-2–dependent neutrophil recruitment.

  • CLEC-1 prevents additional tissue damage following injury.

J Immunol (2024) 212 (7): 1188–1195.

  • Astaxanthin reduces HSV-1–induced lipid peroxidation and STING carbonylation.

  • Astaxanthin promotes STING translocation to the Golgi apparatus and oligomerization.

  • Astaxanthin selectively enhances the cyclic GMP-AMP synthase–STING pathway and inhibits HSV-1 replication.

J Immunol (2024) 212 (7): 1196–1206.

  • FcγRIII participates in cytokine production and bacterial killing in flounder B cells.

  • FcγRIII can rebind onto the surface of flounder B cells.

  • Platelet-derived ADAM17 can regulate the shedding of FcγRIII from flounder B cells.


J Immunol (2024) 212 (7): 1207–1220.

  • We solve the crystal structure of a fish type I subgroup d IFN, LcIFNd.

  • LcIFNd activates the conserved JAK-STAT pathway by binding with CRFB1 and CRFB5.

  • We identify key amino acids of LcIFNd that interact with receptors.

J Immunol (2024) 212 (7): 1221–1231.

  • The mice overexpressing CD109 were resistant to bleomycin-induced pulmonary fibrosis.

  • CD109 protein inhibits pulmonary fibrosis development via inhibiting TGF-β signaling.

  • CD109 might be a novel therapeutic candidate for treating pulmonary fibrosis.


J Immunol (2024) 212 (7): 1232–1243.

  • Single-cell sequencing revealed that IDO1 inhibition activates JAK2-STAT3 in tumor cells.

  • Coinhibition of the IL-6/JAK2/STAT3 pathway and IDO1 effectively reduced tumor growth.


J Immunol (2024) 212 (7): 1244–1253.

  • Alamar NULISAseq demonstrated the highest overall detectability.

  • Alamar and Olink showed the greatest concordance in pairwise platform comparisons.

  • Our study reinforces previous findings related to severity in COVID-19.

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