Issues

IL-33 induces miR-146a expression in mast cells, which reduces cytokine production.

miR-146a KO mast cells have increased IRAK-1 expression and NF-κB activation.

IL-33 also induces release of exosomes containing miR-146a in vitro and in vivo.

NOD-cMHCI/II^−/−.DQ8 mice are susceptible to ICI-induced lethal myocarditis/myositis.

T cells from heart or skeletal muscles are capable of targeting both tissue types.

Shared T cell clones exist within an individual’s heart and skeletal muscles.

Plitidepsin downregulates NF-kB transcriptional activity.

Plitidepsin decreases proinflammatory cytokine levels.

Plitidepsin alleviates respiratory virus disease independent of its antiviral activity.

m6A-modified circRNA388 promoted autophagy to resist Vibrio splendidus infection.

m6A-modified circRNA388-mediated autophagy was dependent on the miR-2008/ULK axis.

The nuclear export of m6A-modified circRNA388 was mediated by the YTHDC1/CRM1 complex.

The structure of ISG75 is constituted by a head domain and a coiled-coil domain.

ISG75 inhibits activation of the classical pathway of the human complement system.

ISG75 inhibits antibody-mediated cellular phagocytosis and cytotoxicity.

MTHFD2 is upregulated by LPS in murine macrophages.

MTHFD2 protects against inflammatory responses in vitro and in vivo.

MTHFD2 restrains inflammation by scavenging ROS through the generation of NADPH.

A small subset of BMDMs secretes a majority of IL-12p40 upon LPS stimulation.

Phenotypic and sequencing analysis shows that this subset contains dendritic cells.

Dendritic cells are consistently present in M-CSF–differentiated BMDMs.

mAbs to MHC-I molecules recognize distinct epitopic sites.

X-ray structures of mAb/MHC-I complexes define these sites in molecular detail.

Details explain peptide-dependent, β₂m-specific, and domain-specific recognition.

Granzyme F expression is highly upregulated in exhausted CD8 TILs.

Granzyme F is cytotoxic to target cells and to the T cells producing it.