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J Immunol (2024) 212 (9): 1395.

BRIEF REVIEWS

J Immunol (2024) 212 (9): 1397–1405.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2024) 212 (9): 1407–1419.

  • IL-10 enhances IL-33–mediated MC activation.

  • IL-10 induction may further exacerbate type 2 inflammation in susceptible patients.

J Immunol (2024) 212 (9): 1420–1427.

  • Inhalation of Asp f 13 primes Th cells that enhance lung eosinophil upon re-exposure.

  • Allergen-specific Th cells are long lived and respond to titrating amounts of antigen.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2024) 212 (9): 1428–1441.

  • Patients have IL-23/TH17 axis dysregulation and elevated IL-23 protein in plasma.

  • IL-23 increases cytokines/chemokines involved in endometriosis pathophysiology.

  • IL-23 treatment results in local immune dysfunction in an endometriosis mouse model.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2024) 212 (9): 1442–1449.

  • In vivo Tfh cell development and germinal center responses require T cell PRMT5.

  • Lack of T cell PRMT5 in influenza infection impairs influenza-specific Tfh and IgM/IgG responses.

  • PRMT5-deficient effector CD4+ T cells exhibit augmented surface expression of CD25.

J Immunol (2024) 212 (9): 1450–1456.

  • HPIV3 is a widespread pathogen causing severe and lethal respiratory illness.

  • We identified neutralizing mAbs that target three nonoverlapping epitopes on HPIV3 F.

  • mAbs encoded by IGHV5-51 show variability in L chain and CDRH3 composition.

J Immunol (2024) 212 (9): 1457–1466.

  • High-affinity receptor-binding virus is resistant to IFN-I–mediated inhibition.

  • High-affinity receptor-binding virus led to defective antiviral T cell immunity.

J Immunol (2024) 212 (9): 1467–1478.

  • A new genetic tool is validated to study IL-21 in regulating immunity.

  • Memory B cell function requires sustained IL-21 in ongoing germinal centers.

  • IL-21 supports selection pressures and germinal center cellular organization.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2024) 212 (9): 1479–1492.

  • Chicken UFL1 (chUFL1) restricts avian influenza virus (AIV) replication.

  • chUFL1 promotes polyubiquitination of STING to facilitate type I IFN production.

  • chUFL1 impedes the viral polymerase complex to suppress AIV replication.

J Immunol (2024) 212 (9): 1493–1503.

  • Our results reveal a possibly novel “hit-and-run” PRM mechanism on pathogens.

  • C1q dynamics were associated with local C1 complex activation.

  • MBL dynamics were associated with overall complement activation.

TRANSPLANTATION

J Immunol (2024) 212 (9): 1504–1518.

  • CXCR5+CD8+ T cells are more potent inhibitors of AMR than CD4+ Treg cells.

  • High alloantibody-producing transplant recipients are CXCR5+CD8+ T cell–deficient.

  • CXCR5+CD8+ T cell–mediated suppression of humoral immunity is antigen-specific.

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