Issues

LAG3 monomers are unable to associate with the TCR/CD3 complex on CD8⁺ T cells.

LAG3 monomers are unable to limit the antitumor activity of CD8⁺ T cells in a mouse model of melanoma.

The anti-LAG3 Ab C9B7W disrupts dimerization of LAG3 and its association with the TCR/CD3 complex.

Gag gene sequence variants are associated with the autoimmune response.

An increase in ORFs positively correlates with disease progression.

Specific amino acid residues of the Gag variants are associated with T1D.

High HED at the HLA-B enhances anti-tumor effect of nivolumab in advanced RCC.

HD IL-2 promotes effector lymphocytes (CD8⁺ and NK cells) extravasation and expansion.

B cells undergo oligoclonal expansion during HD IL-2 therapy.

Treg expansion is associated with myeloid suppression post-HD IL-2 therapy.

NK cells are more sensitive to replication stress, resulting in apoptosis.

Helicase deficiency is linked to replication stress and impaired NK cell function.

TECs require SKI expression for normal thymic medulla development and function.

Splenic CD4⁺ T cell proliferation is reduced from Foxn1^Cre+/−SKI^fl/fl mice in vitro.

Foxn1^Cre+/−SKI^fl/fl mice exhibited reduced EAE disease severity.

This study identifies the novel dual-specificity protein phosphatase PvDUSP14 from shrimp.

PvDUSP14 mediates a negative feedback regulatory loop in the JAK–STAT pathway.

PvDUSP14 modulates homeostasis of JAK–STAT signaling and is involved in immune response.

PAD enzymes and citrullinated proteins are present in COPD airways.

Citrullinated elastin is susceptible to proteolytic degradation.

CANE is a component of the NLRP3 inflammasome.

CANE modulates activation of the NLRP3 inflammasome.

CANE-transgenic mice have a skin-involved CAPS-like phenotype.

IFN response of the immune cell population reflects homogeneous response of single cells.

Immune cell types differ in responding cells’ fraction and response rate.

Female cells respond faster than male cells in the three cell types tested.