Issues

Overexpression of IFIH1^946T resulted in an elevated level of basal type I IFN signaling and increased basal ISG expression.

Recombinant MDA5 with the rs1990760 SNP (A946T) had increased ATPase activity in vitro.

LANCL2 activation induces anti-inflammatory effects in CD4⁺ T cells and phagocytes.

NIM-1324 activates LANCL2 to reduce proteinuria and disease severity in SLE models.

NIM-1324 reduces type I IFN and inflammatory cytokines in human PBMCs.

Distinct T cell changes may predict AML relapse post-HSCT.

Machine learning may predict AML relapse before disease reoccurrence.

In MIS-C, monocytes were hyperactive for phagocytosis and cytokine production.

In MIS-C, NK cells were hypoactive for ADCC, and their function inversely correlated with systemic IL-6.

High affinity anti-CD16 Trispecific reagents were able to rescue NK activity and target SARS-CoV-2.

MARCH8 mediates K27-linked polyubiquitination at K265/K266 and degradation of IL-7Rα.

ΜΑRCH8 deficiency enhances IL-7–triggered CD8⁺ T cell expansion and differentiation.

Maternal vitamin D status regulates fetal hematopoiesis and the adult immune system.

Developmental vitamin D deficiency resulted in fewer Vdr⁺ adult immune cells.

Functional effects of vitamin D deficiency include impaired response to infection.

There is a transient increase in Tim-3⁺ Tregs during chronic LCMV infection.

Tim-3⁺ Tregs promote dysfunction of CD8⁺ T cells during chronic infection with LCMV.

Treg-specific Tim-3 deficiency promotes clearance of chronic LCMV infection.

S1P produced by SphK1 guides immune cell trafficking and activation.

SphK-S1P signaling altered in HBV-infected patients.

HBV manipulates SphK1 expression through transcription factor USF1.

We describe a novel reporter mouse with mScarlet-I knocked in to the Fth1 locus.

High Fth1-mScarlet is restricted to alveolar macrophages in the steady-state lung.

Fth1-mScarlet reports monocyte-to-macrophage differentiation in lung inflammation.

IgA and IgG were abundant in the FGT and demonstrated ex vivo binding to vaginal bacteria.

Total and microbe-binding IgA and IgG correlate with reduced bacterial abundance in the FGT.

Likewise, IgA and IgG correlate with increased proinflammatory cytokines and chemokines.

In vivo CRISPR screening identifies novel epigenetic regulators of CD8⁺ T cells.

The chromatin remodeler CHD7 is a positive regulator of SLEC formation.

Interruption of the CXCR4–CXCL12 axis diminished cell infiltration in aortic allograft.

Plerixafor reduced aortic luminal occlusion on day 30 after transplantation.

Pulsed plerixafor therapy attenuates chronic rejection in a mouse transplant model.

Ly6C^hi monocytes express high α₅β₁ and migrate via elevated CCR2 expression.

F4/80⁺α_v⁺ macrophages in the tumor are protumorigenic and show an M2 TAM phenotype.

FAK signaling is associated with integrin α₅ and α_v–mediated TAM polarization in vitro.