Issues

RASA2 and RASA3 suppress class switch recombination in B cells to IgA.

RASA2 and RASA3 antagonize the canonical TGF-βR signaling pathway in B cells.

The ubiquitination of hemocyanin responds to different pathogen challenges.

PvMulan enhances K48-linked ubiquitination and SUMOylation of hemocyanin.

Inhibiting hemocyanin ubiquitination affects shrimp survival during infections.

Two ATF4 homologs (ATF4-α and ATF4-β) were identified in crayfish.

The interaction of HMGBa, HSP70, and ATF4-β promotes ATF4-β nuclear translocation.

ATF4-β initiates the transcription of ALFs, and ALFs inhibit the replication of WSSV.

TLR and BCR ligands induce IRF1 expression in immature B cells.

IRF1 regulates Notch-dependent signaling in immature B cells.

MZB cell development and innate-like antibody responses require IRF1⁺ B cells.

The D0 domain of rhesus macaque KIR is glycosylated in at least one site.

D0 glycosylation of rhesus macaque KIR impacts surface expression.

KIR-MHC class I binding can be modulated by D0 glycosylation.

Rejection of allogeneic CAR-T cells limits persistence and reduces efficacy.

Optimization of an HLA-E single chain mitigates allorejection of CAR-T cells.

Hypoimmunogenic HLA-E single chain reduces NK cell and CD8⁺ T cell responses.

Lack of USP18 deISGylation function results in severe lung pathology and respiratory failure during persistent LCMV infection.

Extracellular ISG15 correlates with severe pathology in USP18^C61A knock-in mice.

Pathology in USP18^C61A knock-in mice correlates with changes in myeloid cell populations.

Neutrophils are required for neonates to control Bp but are disrupted by PTx.

PTx disrupts neonatal neutrophil recruitment via CXCL1 and C3a pathways.

Nrf2 expression alters microbial burden during viral and viral–bacterial infection.

Loss of Nrf2 increases dendritic cell abundance and activation.

Nrf2^−/− dendritic cells promote regulatory T cell skewing after Ag exposure.

Codon 72 TP53 SNP contributes to biased macrophage polarization.

Mechanisms involve the alteration of redox status and PTEN/PI3K/Akt signaling.

This SNP contributes to hyperinflammation in sepsis and suppression of antitumor immunity.

A knockin reporter mouse for detection and permanent marking of IFN-β–expressing cells is described.

RNase L limits IFN-β and reporter protein expression in RLR-stimulated macrophages.

The microRNA miR-223 regulates colitis-associated tumorigenesis in mice.

miR-223^–/y mice have increased tumors and inflammatory cytokines and chemokines.

Bone marrow chimera and Ab studies link the miR-223^–/y phenotype to myeloid immune cells.

IL-33–producing cells are increased during intestinal bacterial infection.

Overexpression of ST2 on CD8 T cells enhances intestinal Trm cell differentiation.

embp was identified as a highly expressed gene in eosinophils.

An Embp reporter line and Ab were generated to detect zebrafish eosinophils.

Embp was found to localize to eosinophil granules.

We report a new, nonlethal biopsy method to obtain zebrafish scale lymphocytes.

Single-cell expression profiles reveal diverse and novel lymphocyte populations.