Issues

Macrophages form tight cellular connections with hepatic stellate cells in crown-like structures.

Hepatic stellate cells promote macrophage collagen degradation.

The collagen degrading enzyme cathepsin K is expressed by a subset of macrophages in MASH.

Inflammatory cytokine–stimulated UC-MSCs overrepresent WARS1⁺ subpopulation.

WARS1 improves UC-MSCs’ therapeutic effect in a psoriasis-like mouse model.

Ionizing irradiation increases CCL22 expression in AT2 cells.

CCL22 recruits CCR4-positive DCs to injury sites and induces DC tolerance.

CCL22 promotes the proliferation of Tregs by programming DCs in RILI.

Intron 2 of IL-7Rα gene contains a RORE-dependent enhancer, designated CNS9.

CNS9-RORE upregulates IL-7Rα in Vγ4⁺ γδ T cells in peripheral tissues.

CNS9-RORE mutant mice have few adipose Vγ4⁺ γδ T cells and show glucose intolerance.

A temporally controllable RAG2-based lymphoid cell-tracking system is developed.

Most adult B-1a cells have perinatal RAG2 expression histories in their native state.

Adult BM PBs/PCs and B-1a cells with perinatal RAG2 histories share IgH genes.

Location within tissue drives expression of Treg identity.

Biased Treg to CD8⁺ T cell interactions occur in extrafollicular space in children.

Distinct transcription and functional properties define pediatric Tregs.

Male mice fed a high-fat diet have increased P. aeruginosa in the lung postinfection.

COX-2 and PGE₂ are increased in alveolar macrophages of male mice on a high-fat diet.

Nanoparticles inhibiting COX-2 in alveolar macrophages improve bacterial clearance.

Nonhematopoietic cells express MHC II in response to IFN-γ from Chlamydia-specific CD4⁺ Th1 cells.

Chlamydia-specific CD4⁺ Th1 cells express Granzyme B upon Ag sensing.

T cell–specific IFN-γ deficiency abrogates T cell–mediated control of Mtb burden.

IFN-γ^−/− T cells are associated with TB lesion granulocyte abundance and pathology.

T cell–specific IFN-γ deficiency polarizes macrophages toward type 2 immune responses.

Extracellular ATP and cGAMP synergistically induce STING-dependent IFN-β response.

Extracellular ATP dampens p-S174 on LRRC8A to promote VRAC conductance of cGAMP.

Tumor-derived ATP and cGAMP can be exploited to boost antitumor immunity.

Different IRAK3 variants are present in zebrafish and other bony fish.

Mammalian and zebrafish IRAK3s show different functional features.

Zebrafish IRAK3 activates a milder MyD88–TRAF6 pathway than IRAK1/IRAK4.

Distal cutaneous immunization triggers rapid intestinal DC activation and LN homing.

Distal immunization triggers intestinal endothelial permeability and lymph drainage.

Intestinal alert is TNF-α–dependent and generates antigen-specific T cell responses.

IRE-1α plays a crucial role in the viability and Ag presentation of recipient DCs following allogeneic HCT.

The IRE-1α inhibitor B-I09 effectively prevents GVHD by suppressing XBP-1s and RIDD activities.

Two RBPs and two AS events were identified in immune infiltration of LSCCI.

The expression of RBM47 in myeloid cells is high; FLNA is expressed in fibroblasts.

The prognosis of laryngeal carcinoma was correlated with FN1 and FBLN2 genes.