Issues

Lack of endogenous ACOD1 exacerbates immune dysregulation and organ damage in murine lupus.

Lupus-relevant stimuli associated to the TLR7 pathway are associated with regulation of ACOD1 expression in macrophages.

Itaconate serum levels are decreased in SLE patients and associate with disease activity and cardiometabolic dysfunction.

α2B/α2C-Adrenergic receptor activation causes Treg-dependent immune suppression.

AGN-762 represents a novel class of α2 subtype-selective anti-inflammatory drugs.

G3-p239-Nb55 and fenobody-55 can block p239 attachment and HEV infection of host cells.

Fenobody-55 can completely neutralize HEV in vivo with nonenveloped HEV.

The epitope was, to our knowledge, a novel conformational and a highly conserved one.

Apoa1^−/− mice have increases in specific neutrophil and macrophage clusters in the lung during acute inflammation mediated by LPS+HDM, as well as enhanced expression of a common set of proinflammatory genes composed of S100a8, S100a9, and Lcn2.

Modifications in neutrophil and macrophage heterogeneity may contribute to the mechanism by which apoA-I attenuates acute airway inflammation.

Functional diverse myeloid subsets are examined in larval zebrafish with and without burn wounds.

Higher level neutrophil–macrophage communication is examined in burn wound condition.

Zebrafish neutrophil subset signatures are associated with human burn severity.

NLRP3 is palmitoylated on Cys⁴¹⁹ during inflammasome activation.

ZDHHC17 is the predominant enzyme mediating NLRP3 palmitoylation.

2-Bromopalmitate treatment can rescue mice from dextran sulfate sodium–induced colitis.

HIF-1α maintains the basal expression of STING by regulating its transcription.

HIF-1α is involved in the regulation of STING-mediated type I IFN signaling.

HIF-1α inhibits the replication of alphaherpesvirus.

Transcription factor activity in wound macrophages inferred from single cell data.

Networks of transcription factors regulate wound macrophage heterogeneity.

NR4A1 promotes proinflammatory macrophage phenotype during wound healing.

β₂-Integrin dysfunction leads to improved functional outcome in hemorrhagic stroke.

β₂-Integrins regulate microglial responses, which may affect stroke outcome.

Tuberculosis granulomas in rabbit and macaque lungs were imaged with smFISH.

mRNA makers were used for spatial mapping of immune cell subtypes in tuberculosis granulomas.