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J Immunol (2024) 213 (8): 1047.

PILLARS OF IMMUNOLOGY

J Immunol (2024) 213 (8): 1049–1051.

CUTTING EDGE

J Immunol (2024) 213 (8): 1053–1060.

  • IL-2 treatment depletes autoreactive Tfh cells in SLE.

  • IL-2 depletion of Tfh cells does not require Tregs.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2024) 213 (8): 1061–1075.

  • High ED on virus-like immunogens induces IgG independent of T cells or TLR activation.

  • CD19 is required for Ab responses toward virus-like immunogens without iNAs.

  • iNAs reduce the threshold of ED required for individual B cells to initiate IgG.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2024) 213 (8): 1076–1092.

  • CD14+ atypical B cells are consistently detected in healthy human PBMCs.

  • atB cells express AHR and upregulate CD14 and CD9 in response to CpG-ODN.

  • CD9+CD14+ B cells are phagocytic, and loss of CD9 is negatively associated with SLEDAI.

J Immunol (2024) 213 (8): 1093–1104.

  • CSR is programmed for deletional recombination in human B cells.

  • The efficiency of c-NHEJ and S region features affects the orientation of CSR in humans.

J Immunol (2024) 213 (8): 1105–1114.

  • Omicron breakthrough infection induces IgA and IgG anti-S levels similar to hybrid immunity.

  • Hybrid immunity elicits higher levels of ADCC than breakthrough infection.

  • Robust ADCC is associated with a differential IgG reactivity pattern across Spike.

IMMUNE REGULATION

J Immunol (2024) 213 (8): 1115–1124.

  • Treg-restricted deletion of Ebi3 or p35 has a differential effect on the tumor microenvironment.

  • Ebi3 can bind to cytokines outside of the IL-12 cytokine family.

  • Ebi3 exhibits binding to IL-10 and IFN-γ and blocks their signaling and function.

J Immunol (2024) 213 (8): 1125–1138.

  • miR-29a, along with miR-29c, regulates RAG1 expression in B cells of mice and humans.

  • Overexpression of miR-29a decreases V(D)J recombination in pro-B cells of mice.

  • miR-29a exerts a substantial impact on mice immunity and survival.

J Immunol (2024) 213 (8): 1139–1149.

  • CPT2 is required for LCFA oxidation and mitochondrial metabolism in B cells.

  • Chronic or acute deletion of CTP2 does not affect B cell activation in vitro.

  • CPT2 deficiency does not affect humoral immunity in vivo.

IMMUNOGENETICS

J Immunol (2024) 213 (8): 1150–1156.

  • HSP70 autoantibodies from patients with IPF increase lung fibroblast apoptosis resistance.

  • Bcl-2 is upregulated in HSP70 autoantibody-treated fibroblasts.

  • The increased Bcl-2 expression is through enriched binding with H4K16Ac.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2024) 213 (8): 1157–1169.

  • Pups from infected mothers have decreased IL-7 secretion in the bone marrow.

  • Males from infected mothers have a sex-specific defect in the B cell development.

  • Defects in male B cell development during maternal infection alter vaccine responses.

J Immunol (2024) 213 (8): 1170–1186.

  • Basal GR signaling is crucial for optimal memory differentiation.

  • GR blockade and genetic depletion perturbed memory transition and homeostatic turnover of CD8+ T cells.

  • A low dose of GCs reduced cellular ROS levels and enhanced Bcl2 expression in effector cells.

J Immunol (2024) 213 (8): 1187–1201.

  • High temperatures (32°C water) significantly inhibit WSSV replication and pathogenicity.

  • HSP70 plays a crucial protective role against WSSV at elevated temperatures (32°C).

  • The HSP70–Toll4–Dorsal–AMP signaling axis confers protection against WSSV infection at 32°C.

J Immunol (2024) 213 (8): 1202–1211.

  • Absence of IFNAR2 contributes to an Aspergillus-permissive lung environment.

  • IFNAR2 is required to prevent TNF-α–mediated damage during Aspergillus infection.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2024) 213 (8): 1212–1224.

  • Macrophage-specific Mafb-deficient mice showed poor prognosis of AKI.

  • AKI-driven ALOX15 induction was impaired in macrophage-specific Mafb-deficient mice.

  • MAFB in macrophages regulates ALOX15 expression under the COX-2/PGE2/EP4 pathway.

J Immunol (2024) 213 (8): 1225–1233.

  • Macrophages under different states display specific HERV expression patterns.

  • HERVs provide potential transcriptional regulatory elements in trained macrophages.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2024) 213 (8): 1234–1243.

  • OspC is a virulence factor of the Lyme disease spirochete, Borreliella burgdorferi.

  • We report the first structure of OspC in complex with a human mAb.

  • Molecular insights into Ab responses associated with Lyme disease are revealed.

TUMOR IMMUNOLOGY

J Immunol (2024) 213 (8): 1244–1254.

  • A novel approach reveals tumor intrinsic factors regulating neutrophil killing.

  • ITPK1 sensitizes IgA-opsonized tumor cells to killing by neutrophils in vivo.

  • The effect of ITPK1 depends on its kinase domain.

J Immunol (2024) 213 (8): 1255–1263.

  • TLR7 activation in monocyte-derived DCs triggers mROS, boosting IL-12 secretion.

  • TLR7/mROS/IL-12 axis drives potent NK cell responses via imiquimod-activated DCs.

  • TLR7-activated DCs utilize MyD88-independent NF-κB signaling pathway to secrete IL-12.

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