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Adam J. Adler
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Journal Articles

Splicing of ultraconserved poison exon elements in RNA binding proteins reprograms the T effector immune response

Timofey Karginov, Antoine Menoret, Nathan Leclair, Karthik Chandiran, Jenny E Suarez-Ramirez, Keaton Karlinsey, Patrick Murphy, Adam J Adler, Beiyan Zhou, Linda S Cauley, Olga Anczukow, Anthony T Vella
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 148.20.
https://doi.org/10.4049/jimmunol.210.Supp.148.20
Published: 01 May 2023
View article titled, Splicing of ultraconserved poison exon elements in RNA binding proteins reprograms the T effector immune response
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Journal Articles

Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function

Dunia Garcia Cruz, Raghavendra R. Giri, Daylin Gamiotea Turro, Jeremy L. Balsbaugh, Adam J. Adler, Annabelle Rodriguez
Journal: The Journal of Immunology
J Immunol (2021) 207 (9): 2374–2384.
https://doi.org/10.4049/jimmunol.2001188
Published: 01 November 2021
View article titled, Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function
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Includes: Supplementary data
Journal Articles

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells

Payal Mittal, Rebecca Abblett, Joseph M. Ryan, Adam T. Hagymasi, Archibald Agyekum-Yamoah, Julia Svedova, Steven L. Reiner, Marie-Clare St. Rose, Matthew P. Hanley, Anthony T. Vella, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2018) 200 (4): 1513–1526.
https://doi.org/10.4049/jimmunol.1701039
Published: 15 February 2018
View article titled, An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells
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Includes: Supplementary data
Journal Articles

A novel, dual-specific antibody conjugate targeting CD134 and CD137 costimulates T cells and elicits antitumor immunity

Joseph Ryan, Payal Mittal, Julia Svedova, Antoine Menoret, Jeffrey S. Wasser, Adam J. Adler, Anthony T. Vella
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 120.11.
https://doi.org/10.4049/jimmunol.198.Supp.120.11
Published: 01 May 2017
View article titled, A novel, dual-specific antibody conjugate targeting CD134 and CD137 costimulates T cells and elicits antitumor immunity
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Journal Articles

Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis

Naomi Tsurutani, Payal Mittal, Marie-Clare St. Rose, Soo Mun Ngoi, Julia Svedova, Antoine Menoret, Forrest B. Treadway, Reinhard Laubenbacher, Jenny E. Suárez-Ramírez, Linda S. Cauley, Adam J. Adler, Anthony T. Vella
Journal: The Journal of Immunology
J Immunol (2016) 196 (1): 124–134.
https://doi.org/10.4049/jimmunol.1501217
Published: 01 January 2016
View article titled, Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis
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Includes: Supplementary data
Journal Articles

Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy

Payal Mittal, Marie-Clare St. Rose, Xi Wang, Joseph M. Ryan, Jeffrey S. Wasser, Anthony T. Vella, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2015) 195 (12): 5816–5826.
https://doi.org/10.4049/jimmunol.1502032
Published: 15 December 2015
View article titled, Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy
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Includes: Supplementary data
Journal Articles

CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation

Harry Z. Qui, Adam T. Hagymasi, Suman Bandyopadhyay, Marie-Clare St. Rose, Raghunath Ramanarasimhaiah, Antoine Ménoret, Robert S. Mittler, Scott M. Gordon, Steven L. Reiner, Anthony T. Vella, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2011) 187 (7): 3555–3564.
https://doi.org/10.4049/jimmunol.1101244
Published: 01 October 2011
View article titled, CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation
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Journal Articles

Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity

Hung-Rong Yen, Timothy J. Harris, Satoshi Wada, Joseph F. Grosso, Derese Getnet, Monica V. Goldberg, Kai-Li Liang, Tullia C. Bruno, Kristin J. Pyle, Siaw-Li Chan, Robert A. Anders, Cornelia L. Trimble, Adam J. Adler, Tzou-Yien Lin, Drew M. Pardoll, Ching-Tai Huang, Charles G. Drake
Journal: The Journal of Immunology
J Immunol (2009) 183 (11): 7161–7168.
https://doi.org/10.4049/jimmunol.0900368
Published: 01 December 2009
View article titled, Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity
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Journal Articles

The E3 Ubiquitin Ligase Cbl-b Regulates Expansion but Not Functional Activity of Self-Reactive CD4 T Cells

Marie-Clare St. Rose, Harry Z. Qui, Suman Bandyopadhyay, Marianne A. Mihalyo, Adam T. Hagymasi, Robert B. Clark, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2009) 183 (8): 4975–4983.
https://doi.org/10.4049/jimmunol.0901243
Published: 15 October 2009
View article titled, The E3 Ubiquitin Ligase Cbl-b Regulates Expansion but Not Functional Activity of Self-Reactive CD4 T Cells
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Journal Articles

Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation

Suman Bandyopadhyay, Meixiao Long, Harry Z. Qui, Adam T. Hagymasi, Aaron M. Slaiby, Marianne A. Mihalyo, Hector L. Aguila, Robert S. Mittler, Anthony T. Vella, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 7728–7737.
https://doi.org/10.4049/jimmunol.181.11.7728
Published: 01 December 2008
View article titled, Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation
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Journal Articles

Histone Acetylation at the Ifng Promoter in Tolerized CD4 Cells Is Associated with Increased IFN-γ Expression during Subsequent Immunization to the Same Antigen

Meixiao Long, Aaron M. Slaiby, Shuang Wu, Adam T. Hagymasi, Marianne A. Mihalyo, Suman Bandyopadhyay, Anthony T. Vella, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2007) 179 (9): 5669–5677.
https://doi.org/10.4049/jimmunol.179.9.5669
Published: 01 November 2007
View article titled, Histone Acetylation at the <em>Ifng</em> Promoter in Tolerized CD4 Cells Is Associated with Increased IFN-γ Expression during Subsequent Immunization to the Same Antigen
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Journal Articles

Steady State Dendritic Cells Present Parenchymal Self-Antigen and Contribute to, but Are Not Essential for, Tolerization of Naive and Th1 Effector CD4 Cells

Adam T. Hagymasi, Aaron M. Slaiby, Marianne A. Mihalyo, Harry Z. Qui, David J. Zammit, Leo Lefrancois, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2007) 179 (3): 1524–1531.
https://doi.org/10.4049/jimmunol.179.3.1524
Published: 01 August 2007
View article titled, Steady State Dendritic Cells Present Parenchymal Self-Antigen and Contribute to, but Are Not Essential for, Tolerization of Naive and Th1 Effector CD4 Cells
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Journal Articles

Cutting Edge: Paracrine, but Not Autocrine, IL-2 Signaling Is Sustained during Early Antiviral CD4 T Cell Response

Meixiao Long, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2006) 177 (7): 4257–4261.
https://doi.org/10.4049/jimmunol.177.7.4257
Published: 01 October 2006
View article titled, Cutting Edge: Paracrine, but Not Autocrine, IL-2 Signaling Is Sustained during Early Antiviral CD4 T Cell Response
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Journal Articles

T-bet Down-Modulation in Tolerized Th1 Effector CD4 Cells Confers a TCR-Distal Signaling Defect That Selectively Impairs IFN-γ Expression

Meixiao Long, Aaron M. Slaiby, Adam T. Hagymasi, Marianne A. Mihalyo, Alexander C. Lichtler, Steven L. Reiner, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2006) 176 (2): 1036–1045.
https://doi.org/10.4049/jimmunol.176.2.1036
Published: 15 January 2006
View article titled, T-bet Down-Modulation in Tolerized Th1 Effector CD4 Cells Confers a TCR-Distal Signaling Defect That Selectively Impairs IFN-γ Expression
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Journal Articles

Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8+ T Cell Effector Function

Amy D. H. Doody, Joseph T. Kovalchin, Marianne A. Mihalyo, Adam T. Hagymasi, Charles G. Drake, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2004) 172 (10): 6087–6092.
https://doi.org/10.4049/jimmunol.172.10.6087
Published: 15 May 2004
View article titled, Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8<sup>+</sup> T Cell Effector Function
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Journal Articles

In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy

Marianne A. Mihalyo, Amy D. H. Doody, Jeremy P. McAleer, Elizabeth C. Nowak, Meixiao Long, Yi Yang, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2004) 172 (9): 5338–5345.
https://doi.org/10.4049/jimmunol.172.9.5338
Published: 01 May 2004
View article titled, In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy
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Journal Articles

CD4+ T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance Induction

Ching-Tai Huang, David L. Huso, Zhenbing Lu, Tianhong Wang, Gang Zhou, Eugene P. Kennedy, Charles G. Drake, David J. Morgan, Linda A. Sherman, Amy D. Higgins, Drew M. Pardoll, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2003) 170 (8): 3945–3953.
https://doi.org/10.4049/jimmunol.170.8.3945
Published: 15 April 2003
View article titled, CD4<sup>+</sup> T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance Induction
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Journal Articles

Effector CD4 Cells Are Tolerized Upon Exposure to Parenchymal Self-Antigen

Amy D. Higgins, Marianne A. Mihalyo, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2002) 169 (7): 3622–3629.
https://doi.org/10.4049/jimmunol.169.7.3622
Published: 01 October 2002
View article titled, Effector CD4 Cells Are Tolerized Upon Exposure to Parenchymal Self-Antigen
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Journal Articles

CD4 Cell Priming and Tolerization Are Differentially Programmed by APCs upon Initial Engagement

Amy D. Higgins, Marianne A. Mihalyo, Patrick W. McGary, Adam J. Adler
Journal: The Journal of Immunology
J Immunol (2002) 168 (11): 5573–5581.
https://doi.org/10.4049/jimmunol.168.11.5573
Published: 01 June 2002
View article titled, CD4 Cell Priming and Tolerization Are Differentially Programmed by APCs upon Initial Engagement
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Journal Articles

In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions

Adam J. Adler, Ching-Tai Huang, Gregory S. Yochum, David W. Marsh, Drew M. Pardoll
Journal: The Journal of Immunology
J Immunol (2000) 164 (2): 649–655.
https://doi.org/10.4049/jimmunol.164.2.649
Published: 15 January 2000
View article titled, In Vivo CD4<sup>+</sup> T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions
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