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Anne O’Garra
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Journal Articles

High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype

Elizabeth H. Mann, Leona Gabryšová, Paul E. Pfeffer, Anne O’Garra, Catherine M. Hawrylowicz
Journal: The Journal of Immunology
J Immunol (2019) 202 (3): 684–693.
DOI: https://doi.org/10.4049/jimmunol.1800697
Published: 01 February 2019
View article titled, High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17<sup>+</sup>IL-10<sup>+</sup> Memory CD4<sup>+</sup> T Cell Response towards a Single IL-10–Producing Phenotype
Click here to open pdf in another window PDF for High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17<sup>+</sup>IL-10<sup>+</sup> Memory CD4<sup>+</sup> T Cell Response towards a Single IL-10–Producing Phenotype
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Includes: Supplementary data
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T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

Lúcia Moreira-Teixeira, Paul S. Redford, Evangelos Stavropoulos, Nico Ghilardi, Craig L. Maynard, Casey T. Weaver, Ana Paula Freitas do Rosário, Xuemei Wu, Jean Langhorne, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2017) 199 (2): 613–623.
DOI: https://doi.org/10.4049/jimmunol.1601340
Published: 15 July 2017
View article titled, T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
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Includes: Supplementary data
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Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling

Lúcia Moreira-Teixeira, Jeremy Sousa, Finlay W. McNab, Egídio Torrado, Filipa Cardoso, Henrique Machado, Flávia Castro, Vânia Cardoso, Joana Gaifem, Xuemei Wu, Rui Appelberg, António Gil Castro, Anne O’Garra, Margarida Saraiva
Journal: The Journal of Immunology
J Immunol (2016) 197 (12): 4714–4726.
DOI: https://doi.org/10.4049/jimmunol.1600584
Published: 15 December 2016
View article titled, Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
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Includes: Supplementary data
Journal Articles

Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

Anne O’Garra, Leona Gabryšová
Journal: The Journal of Immunology
J Immunol (2016) 197 (11): 4504.
DOI: https://doi.org/10.4049/jimmunol.1601671
Published: 01 December 2016
View article titled, Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role
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Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

Ashleigh Howes, Christina Taubert, Simon Blankley, Natasha Spink, Xuemei Wu, Christine M. Graham, Jiawen Zhao, Margarida Saraiva, Paola Ricciardi-Castagnoli, Gregory J. Bancroft, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2016) 197 (7): 2838–2853.
DOI: https://doi.org/10.4049/jimmunol.1501923
Published: 01 October 2016
View article titled, Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages
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Includes: Supplementary data
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Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815–3822

David F. Fiorentino, Albert Zlotnik, Timothy R. Mosmann, Maureen Howard, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2016) 197 (5): 1539–1546.
Published: 01 September 2016
View article titled, Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815–3822
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Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444–3451

David F. Fiorentino, Albert Zlotnik, Paulo Vieira, Timothy R. Mosmann, Maureen Howard, Kevin W. Moore, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2016) 197 (5): 1531–1538.
Published: 01 September 2016
View article titled, Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444–3451
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Journal Articles

Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

In Special Collection:
Pillars of Immunology
Anne O’Garra, Leona Gabryšová
Journal: The Journal of Immunology
J Immunol (2016) 196 (11): 4423–4425.
DOI: https://doi.org/10.4049/jimmunol.1600646
Published: 01 June 2016
View article titled, Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role
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Journal Articles

The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease

Laura Conejero, Krzysztof Potempa, Christine M. Graham, Natasha Spink, Simon Blankley, Francisco J. Salguero, Rungnapa Pankla-Sranujit, Prasong Khaenam, Jacques F. Banchereau, Virginia Pascual, Damien Chaussabel, Ganjana Lertmemongkolchai, Anne O’Garra, Gregory J. Bancroft
Journal: The Journal of Immunology
J Immunol (2015) 195 (7): 3248–3261.
DOI: https://doi.org/10.4049/jimmunol.1500641
Published: 01 October 2015
View article titled, The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease
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Includes: Supplementary data
Journal Articles

Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages

Finlay W. McNab, John Ewbank, Ashleigh Howes, Lucia Moreira-Teixeira, Anna Martirosyan, Nico Ghilardi, Margarida Saraiva, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2014) 193 (7): 3600–3612.
DOI: https://doi.org/10.4049/jimmunol.1401088
Published: 01 October 2014
View article titled, Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages
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Includes: Supplementary data
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Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase

Srividya Sriskantharajah, Eva Gückel, Niki Tsakiri, Katrin Kierdorf, Christine Brender, Abduelhakem Ben-Addi, Marc Veldhoen, Philip N. Tsichlis, Brigitta Stockinger, Anne O’Garra, Marco Prinz, George Kollias, Steven C. Ley
Journal: The Journal of Immunology
J Immunol (2014) 192 (8): 3518–3529.
DOI: https://doi.org/10.4049/jimmunol.1300172
Published: 15 April 2014
View article titled, Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase
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Includes: Supplementary data
Journal Articles

TPL-2–ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production

Finlay W. McNab, John Ewbank, Ricardo Rajsbaum, Evangelos Stavropoulos, Anna Martirosyan, Paul S. Redford, Xuemei Wu, Christine M. Graham, Margarida Saraiva, Philip Tsichlis, Damien Chaussabel, Steven C. Ley, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2013) 191 (4): 1732–1743.
DOI: https://doi.org/10.4049/jimmunol.1300146
Published: 15 August 2013
View article titled, TPL-2–ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production
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Includes: Supplementary data
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Blockade of IL-10 Signaling during Bacillus Calmette-Guérin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN-γ and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection

Jonathan M. Pitt, Evangelos Stavropoulos, Paul S. Redford, Amy M. Beebe, Gregory J. Bancroft, Douglas B. Young, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2012) 189 (8): 4079–4087.
DOI: https://doi.org/10.4049/jimmunol.1201061
Published: 15 October 2012
View article titled, Blockade of IL-10 Signaling during Bacillus Calmette-Guérin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN-γ and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection
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Includes: Supplementary data
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IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

Ana Paula Freitas do Rosário, Tracey Lamb, Philip Spence, Robin Stephens, Agathe Lang, Axel Roers, Werner Muller, Anne O’Garra, Jean Langhorne
Journal: The Journal of Immunology
J Immunol (2012) 188 (3): 1178–1190.
DOI: https://doi.org/10.4049/jimmunol.1102755
Published: 01 February 2012
View article titled, IL-27 Promotes IL-10 Production by Effector Th1 CD4<sup>+</sup> T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection
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Includes: Supplementary data
Journal Articles

NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2–Dependent ERK Activation

Huei-Ting Yang, Yanyan Wang, Xixing Zhao, Ezana Demissie, Stamatia Papoutsopoulou, Agnes Mambole, Anne O’Garra, Michal F. Tomczak, Susan E. Erdman, James G. Fox, Steven C. Ley, Bruce H. Horwitz
Journal: The Journal of Immunology
J Immunol (2011) 186 (4): 1989–1996.
DOI: https://doi.org/10.4049/jimmunol.1001003
Published: 15 February 2011
View article titled, NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2–Dependent ERK Activation
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Includes: Supplementary data
Journal Articles

Pillars Article: Development of TH1 CD4+ T Cells Through IL-12 Produced by Listeria-Induced Macrophages. 1993. Science 260(5107): 547–549

Chyi-Song Hsieh, Steven E. Macatonia, Catherine S. Tripp, Stanley F. Wolf, Anne O'Garra, Kenneth M. Murphy
Journal: The Journal of Immunology
J Immunol (2008) 181 (7): 4437–4439.
Published: 01 October 2008
View article titled, Pillars Article: Development of T<sub>H</sub>1 CD4<sup>+</sup> T Cells Through IL-12 Produced by Listeria-Induced Macrophages. 1993. Science 260(5107): 547–549
Click here to open pdf in another window PDF for Pillars Article: Development of T<sub>H</sub>1 CD4<sup>+</sup> T Cells Through IL-12 Produced by Listeria-Induced Macrophages. 1993. Science 260(5107): 547–549
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Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals

André Boonstra, Ricardo Rajsbaum, Mary Holman, Rute Marques, Carine Asselin-Paturel, João Pedro Pereira, Elizabeth E. M. Bates, Shizuo Akira, Paulo Vieira, Yong-Jun Liu, Giorgio Trinchieri, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2006) 177 (11): 7551–7558.
DOI: https://doi.org/10.4049/jimmunol.177.11.7551
Published: 01 December 2006
View article titled, Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals
Click here to open pdf in another window PDF for Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals
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GATA-3 Directly Remodels the IL-10 Locus Independently of IL-4 in CD4+ T Cells

John Shoemaker, Margarida Saraiva, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2006) 176 (6): 3470–3479.
DOI: https://doi.org/10.4049/jimmunol.176.6.3470
Published: 15 March 2006
View article titled, GATA-3 Directly Remodels the IL-10 Locus Independently of IL-4 in CD4<sup>+</sup> T Cells
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IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

Pedro L. Vieira, Jillian R. Christensen, Sophie Minaee, Emma J. O’Neill, Franck J. Barrat, André Boonstra, Thomas Barthlott, Brigitta Stockinger, David C. Wraith, Anne O’Garra
Journal: The Journal of Immunology
J Immunol (2004) 172 (10): 5986–5993.
DOI: https://doi.org/10.4049/jimmunol.172.10.5986
Published: 15 May 2004
View article titled, IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells
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Friend of GATA Is Expressed in Naive Th Cells and Functions As a Repressor of GATA-3-Mediated Th2 Cell Development

Hirokazu Kurata, Hyun-Jun Lee, Terri McClanahan, Robert L. Coffman, Anne O’Garra, Naoko Arai
Journal: The Journal of Immunology
J Immunol (2002) 168 (9): 4538–4545.
DOI: https://doi.org/10.4049/jimmunol.168.9.4538
Published: 01 May 2002
View article titled, Friend of GATA Is Expressed in Naive Th Cells and Functions As a Repressor of GATA-3-Mediated Th2 Cell Development
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