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Arlene H. Sharpe
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Journal Articles

In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells

Martin W. LaFleur, Jasmin M. D’Andrea, Dillon G. Patterson, Ivy S. L. Streeter, Matthew A. Coxe, Jossef F. Osborn, Lauren E. Milling, Qin Tjokrosurjo, Jacob E. Gillis, Thao H. Nguyen, Marc A. Schwartz, Nir Hacohen, John G. Doench, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2024) 213 (10): 1528–1541.
https://doi.org/10.4049/jimmunol.2400213
Published: 07 October 2024
View article titled, In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells
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Includes: Supplementary data
Journal Articles

PD-1 agonist modulates ILC2 metabolism and ameliorates airway hyperreactivity

Georges Doumet Helou, Pedram Shafiei-Jahani, Richard Lo, Emily Diane Howard, Benjamin P Hurrell, Lauriane Galle-Treger, Jacob Dean Painter, Gavin Lewis, Pejman Soroosh, Arlene H Sharpe, Omid Akbari
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 109.15.
https://doi.org/10.4049/jimmunol.208.Supp.109.15
Published: 01 May 2022
View article titled, PD-1 agonist modulates ILC2 metabolism and ameliorates airway hyperreactivity
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PD-1 restricts the development and effector function of tissue regulatory T cells in experimental autoimmune encephalomyelitis

Dan Liang, Jennifer Judge, Samuel Markson, Samantha Guinn, Jenna Lynn Collier, Osmaan Shahid, Sasikanth Manne, Juhi Kuchroo, Megan Fung, Kristen E Pauken, Dario AA Vignali, John E Wherry, Arlene H Sharpe
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 163.01.
https://doi.org/10.4049/jimmunol.208.Supp.163.01
Published: 01 May 2022
View article titled, PD-1 restricts the development and effector function of tissue regulatory T cells in experimental autoimmune encephalomyelitis
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PD-1 inhibition on pulmonary ILC2s promotes TNF-α production and restricts progression of metastatic melanoma tumor growth

Emily Diane Howard, Benjamin P Hurrell, Doumet Georges Helou, Christine Quach, Jacob D Painter, Pedram Shafiei-Jahani, Marshall Fung, Arlene H Sharpe, Omid Akbari
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 163.07.
https://doi.org/10.4049/jimmunol.208.Supp.163.07
Published: 01 May 2022
View article titled, PD-1 inhibition on pulmonary ILC2s promotes TNF-α production and restricts progression of metastatic melanoma tumor growth
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Single-cell analyses characterize circulating anti-tumor CD8+ T cells in mice and humans and identify markers for their enrichment

Kristen E Pauken, Osmaan Shahid, Kaitlyn A Lagattuta, Kelly M Mahuron, Jacob M Luber, Margaret M Lowe, Linglin Huang, Conor Delaney, Jaclyn Long, Megan E Fung, Kathleen Newcomer, Katy K Tsai, Melissa Chow, Samantha Guinn, Juhi R Kuchroo, Kelly P Burke, Jason M Schenkel, Michael D Rosenblum, Adil I Daud, Arlene H Sharpe, Meromit Singer
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 26.02.
https://doi.org/10.4049/jimmunol.206.Supp.26.02
Published: 01 May 2021
View article titled, Single-cell analyses characterize circulating anti-tumor CD8<sup>+</sup> T cells in mice and humans and identify markers for their enrichment
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Journal Articles

T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

Waradon Sungnak, Allon Wagner, Monika S. Kowalczyk, Lloyd Bod, Yoon-Chul Kye, Peter T. Sage, Arlene H. Sharpe, Raymond A. Sobel, Francisco J. Quintana, Orit Rozenblatt-Rosen, Aviv Regev, Chao Wang, Nir Yosef, Vijay K. Kuchroo
Journal: The Journal of Immunology
J Immunol (2020) 205 (12): 3247–3262.
https://doi.org/10.4049/jimmunol.2000748
Published: 15 December 2020
View article titled, T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity
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Includes: Supplementary data
Journal Articles

PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease

Stephanie Rhee, Ethan George Aguilar, Katelyn Paz, Ryan Flynn, Juhi Kuchroo, Peter Sage, Arlene H Sharpe, Gordon J Freeman, Rafi Ahmed, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.8.
https://doi.org/10.4049/jimmunol.204.Supp.87.8
Published: 01 May 2020
View article titled, PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease
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Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)

Ethan George Aguilar, Stephanie Rhee, Govindarajan Thangavelu, Michael Loschi, Katelyn Paz, Asim Saha, Joanna Ly, Peter Sage, Arlene H Sharpe, Ivan Maillard, William J Murphy, Jonathan S Serody, Suji Jin, Sara Bolivar Wagers, Jemma Nicholls, Geoffrey Hill, Kelli PA MacDonald, Ewoud Compeer, Michael Dustin, Roddy O’Connor, Tim Sparwasser, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.2.
https://doi.org/10.4049/jimmunol.204.Supp.87.2
Published: 01 May 2020
View article titled, Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)
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Journal Articles

Intracellular Signaling triggered by engagement of PD-1 by PD-L1

Xia Bu, Melissa Bu, Ping Hua, Baogong Zhu, Arlene H Sharpe, Gordon J Freeman
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 78.24.
https://doi.org/10.4049/jimmunol.204.Supp.78.24
Published: 01 May 2020
View article titled, Intracellular Signaling triggered by engagement of PD-1 by PD-L1
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Journal Articles

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Lauriane Galle, Ishwarya Sankaranarayanan, Benjamin P Hurrell, Emily Howard, Richard Lo, Hadi Maazi, Gavin Lewis, Homayon Banie, Alan L Epstein, Peisheng Hu, Virender K Rehan, Frank D Gilliland, Hooman Allayee, Pejman Soroosh, Arlene H Sharpe, Omid Akbari
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 122.10.
https://doi.org/10.4049/jimmunol.202.Supp.122.10
Published: 01 May 2019
View article titled, Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
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Journal Articles

Treg-specific LAG3 deletion reveals a key role for LAG3 in regulatory T cells to inhibit CNS autoimmunity

Youg Raj Thaker, Lawrence P. Andrews, Creg J. Workman, Dario A. A. Vignali, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 101.7.
https://doi.org/10.4049/jimmunol.200.Supp.101.7
Published: 01 May 2018
View article titled, Treg-specific LAG3 deletion reveals a key role for LAG3 in regulatory T cells to inhibit CNS autoimmunity
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Journal Articles

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

Peter T. Sage, Frank A. Schildberg, Raymond A. Sobel, Vijay K. Kuchroo, Gordon J. Freeman, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2018) 200 (8): 2592–2602.
https://doi.org/10.4049/jimmunol.1701231
Published: 15 April 2018
View article titled, Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function
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Includes: Supplementary data
Journal Articles

Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells

Ruan Zhang, Peter T. Sage, Kelsey Finn, Alexandria Huynh, Bruce R. Blazar, Francesco Marangoni, Thorsten R. Mempel, Arlene H. Sharpe, Laurence A. Turka
Journal: The Journal of Immunology
J Immunol (2018) 200 (7): 2505–2506.
https://doi.org/10.4049/jimmunol.1800150
Published: 01 April 2018
View article titled, Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
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Journal Articles

Inhibitors of the PD-1 Pathway in Tumor Therapy

In Special Collection:
The Cancer Immunotherapy Revolution: Mechanistic Insights , Translating Immunology
Martin W. LaFleur, Yuki Muroyama, Charles G. Drake, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2018) 200 (2): 375–383.
https://doi.org/10.4049/jimmunol.1701044
Published: 15 January 2018
View article titled, Inhibitors of the PD-1 Pathway in Tumor Therapy
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Journal Articles

PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease

Kathryn W. Juchem, Faruk Sacirbegovic, Cuiling Zhang, Arlene H. Sharpe, Kerry Russell, Jennifer M. McNiff, Anthony J. Demetris, Mark J. Shlomchik, Warren D. Shlomchik
Journal: The Journal of Immunology
J Immunol (2018) 200 (2): 834–846.
https://doi.org/10.4049/jimmunol.1701076
Published: 15 January 2018
View article titled, PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease
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Includes: Supplementary data
Journal Articles

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells

Ruan Zhang, Peter T. Sage, Kelsey Finn, Alexandria Huynh, Bruce R. Blazar, Francesco Marangoni, Thorsten R. Mempel, Arlene H. Sharpe, Laurence A. Turka
Journal: The Journal of Immunology
J Immunol (2017) 199 (12): 3972–3980.
https://doi.org/10.4049/jimmunol.1700409
Published: 15 December 2017
View article titled, B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
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Includes: Supplementary data
Journal Articles

CD8+ T cell-independent mechanisms of PD-1-mediated suppression of anti-tumor immunity in mice

Kristen E Pauken, Vikram Juneja, Kathleen McGuire, Martin LaFleur, Juhi Kuchroo, Peter Sage, Nicolas Chevrier, Gordon J Freeman, Arlene H Sharpe
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 205.11.
https://doi.org/10.4049/jimmunol.198.Supp.205.11
Published: 01 May 2017
View article titled, CD8<sup>+</sup> T cell-independent mechanisms of PD-1-mediated suppression of anti-tumor immunity in mice
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Journal Articles

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells

Shannon L. McArdel, Daniel R. Brown, Raymond A. Sobel, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2016) 197 (8): 3038–3048.
https://doi.org/10.4049/jimmunol.1600706
Published: 15 October 2016
View article titled, Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4<sup>+</sup> T Cells
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Includes: Supplementary data
Journal Articles

CD48 is upregulated on pathogenic CD4+ T cells and is a therapeutic target in experimental autoimmune encephalomyelitis

Shannon McArdel, Daniel Brown, Arlene H Sharpe
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 71.2.
https://doi.org/10.4049/jimmunol.196.Supp.71.2
Published: 01 May 2016
View article titled, CD48 is upregulated on pathogenic CD4+ T cells and is a therapeutic target in experimental autoimmune encephalomyelitis
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Journal Articles

Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse

Steve Oghumu, Ran Dong, Sanjay Varikuti, Todd Shawler, Thomas Kampfrath, Cesar A. Terrazas, Claudio Lezama-Davila, Brian M. M. Ahmer, Caroline C. Whitacre, Sanjay Rajagopalan, Richard Locksley, Arlene H. Sharpe, Abhay R. Satoskar
Journal: The Journal of Immunology
J Immunol (2013) 190 (5): 2229–2240.
https://doi.org/10.4049/jimmunol.1201170
Published: 01 March 2013
View article titled, Distinct Populations of Innate CD8<sup>+</sup> T Cells Revealed in a CXCR3 Reporter Mouse
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Includes: Supplementary data