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Ashutosh K Mangalam
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Journal Articles

Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells

Stephanie R Peterson, Samantha Jensen, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 77.14.
https://doi.org/10.4049/jimmunol.210.Supp.77.14
Published: 01 May 2023
View article titled, Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells
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Journal Articles

Obesity Modulated Gut Microbiota Exacerbate Disease Severity in HLA-Class II Transgenic Mouse Model of Multiple Sclerosis

Shailesh K Shahi, Sudeep Ghimire, Peter Lehman, Allison G Rux, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 77.09.
https://doi.org/10.4049/jimmunol.210.Supp.77.09
Published: 01 May 2023
View article titled, Obesity Modulated Gut Microbiota Exacerbate Disease Severity in HLA-Class II Transgenic Mouse Model of Multiple Sclerosis
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Journal Articles

Investigating the requirement of IL-17A and IFNg in EAE disease development using HLA-DR3.IL-17A −/−.IFNg −/−transgenic mice

Ti-Ara J Turner, Stephanie Peterson, Shailesh Shahi, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 170.04.
https://doi.org/10.4049/jimmunol.210.Supp.170.04
Published: 01 May 2023
View article titled, Investigating the requirement of IL-17A and IFNg in EAE disease development using HLA-DR3.IL-17A <sup>−/−</sup>.IFNg <sup>−/−</sup>transgenic mice
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Journal Articles

Gut bacteria-derived isoflavone metabolites ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor engagement

Stephanie R Peterson, Samantha Jensen, Dalton Dencklau, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 60.09.
https://doi.org/10.4049/jimmunol.208.Supp.60.09
Published: 01 May 2022
View article titled, Gut bacteria-derived isoflavone metabolites ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor engagement
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Journal Articles

HLA Class II Polymorphisms Influence Gut Microbiota Composition and Modulate Disease in Transgenic Mice Model of Multiple Sclerosis

Shailesh K Shahi, Soham Ali, Peter Lehman, Sudeep Ghimire, Natalya V Guseva, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 158.15.
https://doi.org/10.4049/jimmunol.208.Supp.158.15
Published: 01 May 2022
View article titled, HLA Class II Polymorphisms Influence Gut Microbiota Composition and Modulate Disease in Transgenic Mice Model of Multiple Sclerosis
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Journal Articles

Interleukin-17A deficient mice microbiota induced regulatory T cells and suppressed experimental autoimmune encephalomyelitis (EAE) in WT HLA-DR3 transgenic mice

Shailesh K Shahi, Samantha N. Jensen, Sudeep Ghimire, CheyAnne Q. Carter, Natalya V. Guseva, Katherine Gibson-Corley, Aaron D. Bossler, Sukirth M. Ganesan, Nitin J. Karandikar, Ashutosh K. Mangalam
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 105.10.
https://doi.org/10.4049/jimmunol.206.Supp.105.10
Published: 01 May 2021
View article titled, Interleukin-17A deficient mice microbiota induced regulatory T cells and suppressed experimental autoimmune encephalomyelitis (EAE) in WT HLA-DR3 transgenic mice
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Journal Articles

Isoflavone Rich Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) through Modulation of Gut Bacteria Depleted in Multiple Sclerosis Patients

Samantha N Freedman, Shailesh K Shahi, Kasra Zarei, Arnav Gupta, Natalya V Guseva, Aaron D Bossler, Kevin L Legge, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 141.12.
https://doi.org/10.4049/jimmunol.204.Supp.141.12
Published: 01 May 2020
View article titled, Isoflavone Rich Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) through Modulation of Gut Bacteria Depleted in Multiple Sclerosis Patients
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Journal Articles

Microbiota-driven regulatory T cells suppress experimental autoimmune encephalomyelitis (EAE) in interleukin-17A deficient HLA class-II transgenic mice model of multiple sclerosis (MS)

Shailesh K Shahi, Samantha N Freedman, Alexandra C Murra, Nicole Cady, Arnav Gupta, Natalya V Guseva, Katherine N Gibson-Corley, Aaron D Bossler, Sukirth M Ganesan, Nitin J Karandikar, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 141.11.
https://doi.org/10.4049/jimmunol.204.Supp.141.11
Published: 01 May 2020
View article titled, Microbiota-driven regulatory T cells suppress experimental autoimmune encephalomyelitis (EAE) in interleukin-17A deficient HLA class-II transgenic mice model of multiple sclerosis (MS)
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Journal Articles

Linking diet, gut microbiota and autoimmunity: A phytoestrogen diet alters the gut microbiota and influences Experimental Autoimmune Encephalomyelitis (EAE)

Samantha N Freedman, Shailesh Shahi, Kasra Zarei, Arnav Gupta, Natalya Guseva, Aaron Bossler, Kevin L Legge, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 178.13.
https://doi.org/10.4049/jimmunol.202.Supp.178.13
Published: 01 May 2019
View article titled, Linking diet, gut microbiota and autoimmunity: A phytoestrogen diet alters the gut microbiota and influences Experimental Autoimmune Encephalomyelitis (EAE)
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Journal Articles

IL-17A control CNS inflammatory disease by regulating Treg cells through modulation of gut microbiota in HLA class-II transgenic mice model of multiple sclerosis (MS)

Shailesh K Shahi, Samantha N Freedman, Alexandra C Murra, Kasra Zarei, Natalya V Guseva, Katherine Gibson Corley, Aaron Bossler, Nitin J Karandikar, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 178.14.
https://doi.org/10.4049/jimmunol.202.Supp.178.14
Published: 01 May 2019
View article titled, IL-17A control CNS inflammatory disease by regulating Treg cells through modulation of gut microbiota in HLA class-II transgenic mice model of multiple sclerosis (MS)
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Journal Articles

Human gut commensal Prevotella histicola ameliorates disease as efficiently as Copaxone and Interferon-β in a preclinical animal model of multiple sclerosis

Shailesh K. Shahi, Samantha N. Freedman, Katherine Gibson-Corley, Nitin J. Karandikar, Joseph A. Murray, Ashutosh K. Mangalam
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 54.2.
https://doi.org/10.4049/jimmunol.200.Supp.54.2
Published: 01 May 2018
View article titled, Human gut commensal <em>Prevotella histicola</em> ameliorates disease as efficiently as Copaxone and Interferon-β in a preclinical animal model of multiple sclerosis
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Journal Articles

Blood-based untargeted metabolomics in Relapsing-Remitting Multiple Sclerosis revealed testable therapeutic target

Shailendra Giri, Laila poisson, Jaspreet Singh, Indrani Datta, Hamid Suhail, Ashutosh K. Mangalam, Mirela Cerghet, stanton B. Elias, Ramandeep Rattan
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 45.24.
https://doi.org/10.4049/jimmunol.200.Supp.45.24
Published: 01 May 2018
View article titled, Blood-based untargeted metabolomics in Relapsing-Remitting Multiple Sclerosis revealed testable therapeutic target
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Journal Articles

Human gut-derived commensal Prevotella histicola suppress experimental autoimmune encephalomyelitis in humanized mice

Shailesh K Shahi, Samantha Freedman, David Luckey, Melissa Karau, Eric Marietta, Rok-Seon Choung, Katherine Gibson-Corley, Robin Patel, Moses Rodriguez, Chella S David, Veena Taneja, Joseph A Murray, Ashutosh K Mangalam
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 219.18.
https://doi.org/10.4049/jimmunol.198.Supp.219.18
Published: 01 May 2017
View article titled, Human gut-derived commensal <em>Prevotella histicola</em> suppress experimental autoimmune encephalomyelitis in humanized mice
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Journal Articles

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis

Ashutosh K. Mangalam, Ramandeep Rattan, Hamid Suhail, Jaspreet Singh, Md Nasrul Hoda, Mandar Deshpande, Sadanand Fulzele, Alexander Denic, Viji Shridhar, Ashok Kumar, Benoit Viollet, Moses Rodriguez, Shailendra Giri
Journal: The Journal of Immunology
J Immunol (2016) 197 (3): 747–760.
https://doi.org/10.4049/jimmunol.1501549
Published: 01 August 2016
View article titled, AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis
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Includes: Supplementary data
Journal Articles

Gut microbiota dysbiosis in patients with Multiple Sclerosis

Ashutosh K Mangalam, Nicholas Chia, Jun Chen, Krishna R Kalari, Janet Z Yao, Martina Novotna, Mateo Paz Soldan, David Luckey, Eric V Marietta, Patricio R Jeraldo, Xianfeng Chen, Brian G Weinshenker, Moses Rodriguez, Orhun H Kantarci, Orhun H Kantarci, Heidi Nelson, Joseph A Murray
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 118.13.
https://doi.org/10.4049/jimmunol.196.Supp.118.13
Published: 01 May 2016
View article titled, Gut microbiota dysbiosis in patients with Multiple Sclerosis
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Journal Articles

Absence of IFN-γ Increases Brain Pathology in Experimental Autoimmune Encephalomyelitis–Susceptible DRB1*0301.DQ8 HLA Transgenic Mice through Secretion of Proinflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the Central Nervous System

Ashutosh K. Mangalam, Ningling Luo, David Luckey, Louisa Papke, Alyssa Hubbard, Arika Wussow, Michele Smart, Shailendra Giri, Moses Rodriguez, Chella David
Journal: The Journal of Immunology
J Immunol (2014) 193 (10): 4859–4870.
https://doi.org/10.4049/jimmunol.1302008
Published: 15 November 2014
View article titled, Absence of IFN-γ Increases Brain Pathology in Experimental Autoimmune Encephalomyelitis–Susceptible DRB1*0301.DQ8 HLA Transgenic Mice through Secretion of Proinflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the Central Nervous System
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Includes: Supplementary data
Journal Articles

HLA Class II Molecules Influence Susceptibility versus Protection in Inflammatory Diseases by Determining the Cytokine Profile

In Special Collection:
Brief Reviews
Ashutosh K. Mangalam, Veena Taneja, Chella S. David
Journal: The Journal of Immunology
J Immunol (2013) 190 (2): 513–519.
https://doi.org/10.4049/jimmunol.1201891
Published: 15 January 2013
View article titled, HLA Class II Molecules Influence Susceptibility versus Protection in Inflammatory Diseases by Determining the Cytokine Profile
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Journal Articles

Dual role of CD8+ T cells in PLPp91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3.Abo transgenic mice (99.1)

Ashutosh K Mangalam, David Luckey, Michelle Smart, Larry Pease, Moses Rodriguez, Chella David
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 99.1.
https://doi.org/10.4049/jimmunol.182.Supp.99.1
Published: 01 April 2009
View article titled, Dual role of CD8+ T cells in PLPp91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3.Abo transgenic mice (99.1)
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Journal Articles

HLA-DQ6 (DQB1*0601) molecule modulate PLPp91-110 induced EAE in DR3 (DRB1*0301) mice through apoptosis. (130.6)

Ashutosh K. Mangalam, Moses Rodriguez, Chella S David
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S228.
https://doi.org/10.4049/jimmunol.178.Supp.130.6
Published: 01 April 2007
View article titled, HLA-DQ6 (DQB1*0601) molecule modulate PLPp91-110 induced EAE in DR3 (DRB1*0301) mice through apoptosis. (130.6)
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