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Journal Articles

Similarities in B Cell Defects between Aging and Obesity

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In Special Collection:
Brief Reviews
Daniela Frasca, Maria Romero, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2024) 213 (10): 1407–1413.
https://doi.org/10.4049/jimmunol.2300670
Published: 15 November 2024
View articletitled, Similarities in B Cell Defects between Aging and Obesity
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Journal Articles

MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals

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Daniela Frasca, Alain Diaz, Maria Romero, Franco Ferracci, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2015) 195 (5): 2134–2140.
https://doi.org/10.4049/jimmunol.1500520
Published: 01 September 2015
View articletitled, MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals
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Journal Articles

A Molecular Mechanism for TNF-α–Mediated Downregulation of B Cell Responses

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Daniela Frasca, Maria Romero, Alain Diaz, Sarah Alter-Wolf, Michelle Ratliff, Ana Marie Landin, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2012) 188 (1): 279–286.
https://doi.org/10.4049/jimmunol.1003964
Published: 01 January 2012
View articletitled, A Molecular Mechanism for TNF-α–Mediated Downregulation of B Cell Responses
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Journal Articles

Reduced response to influenza vaccine associates with reduced AID in aged human B lymphocytes (34.5)

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Bonnie B. Blomberg, Maria Romero, Ana Marie Landin, Alain Diaz, Richard L. Riley, Daniela Frasca
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 34.5.
https://doi.org/10.4049/jimmunol.182.Supp.34.5
Published: 01 April 2009
View articletitled, Reduced response to influenza vaccine associates with reduced AID in aged human B lymphocytes (34.5)
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Journal Articles

Protein phosphatase 2A (PP2A) is involved in the age-related down-regulation of E47 mRNA stability (84.14)

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Bonnie B. Blomberg, Ana Marie Landin, Alain Diaz, Richard L. Riley, Daniela Frasca
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 84.14.
https://doi.org/10.4049/jimmunol.182.Supp.84.14
Published: 01 April 2009
View articletitled, Protein phosphatase 2A (PP2A) is involved in the age-related down-regulation of E47 mRNA stability (84.14)
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Journal Articles

Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression

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Sarah Alter-Wolf, Bonnie B. Blomberg, Richard L. Riley
Journal: The Journal of Immunology
J Immunol (2009) 182 (1): 138–147.
https://doi.org/10.4049/jimmunol.182.1.138
Published: 01 January 2009
View articletitled, Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression
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Journal Articles

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

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Daniela Frasca, Ana Marie Landin, Suzanne C. Lechner, John G. Ryan, Robert Schwartz, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2008) 180 (8): 5283–5290.
https://doi.org/10.4049/jimmunol.180.8.5283
Published: 15 April 2008
View articletitled, Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells
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Journal Articles

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

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In Special Collection:
Brief Reviews
Daniela Frasca, Ana Marie Landin, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2008) 180 (5): 2741–2746.
https://doi.org/10.4049/jimmunol.180.5.2741
Published: 01 March 2008
View articletitled, Mechanisms for Decreased Function of B Cells in Aged Mice and Humans
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Journal Articles

Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA

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Daniela Frasca, Ana Marie Landin, Juan P. Alvarez, Perry J. Blackshear, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2007) 179 (2): 918–927.
https://doi.org/10.4049/jimmunol.179.2.918
Published: 15 July 2007
View articletitled, Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA
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Journal Articles

A molecular mechanism for the increased degradation of E47 mRNA in old murine B cells involves TTP (tristetraprolin) (83.5)

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daniela frasca, ana marie landin, juan p alvarez, richard l riley, bonnie b blomberg
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S112.
https://doi.org/10.4049/jimmunol.178.Supp.83.5
Published: 01 April 2007
View articletitled, A molecular mechanism for the increased degradation of E47 mRNA in old murine B cells involves TTP (tristetraprolin) (83.5)
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Journal Articles

Decreases in E2A, AID, and Ig class switch show intrinsic defects in human B cells with age (85.14)

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bonnie b blomberg, ana marie landin, richard l riley, suzanne c lechner, john g ryan, robert schwartz, daniela frasca
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S120–S121.
https://doi.org/10.4049/jimmunol.178.Supp.85.14
Published: 01 April 2007
View articletitled, Decreases in E2A, AID, and Ig class switch show intrinsic defects in human B cells with age (85.14)
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Journal Articles

Accelerated Notch-Dependent Degradation of E47 Proteins in Aged B Cell Precursors Is Associated with Increased ERK MAPK Activation

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Anne M. King, Elaine Van der Put, Bonnie B. Blomberg, Richard L. Riley
Journal: The Journal of Immunology
J Immunol (2007) 178 (6): 3521–3529.
https://doi.org/10.4049/jimmunol.178.6.3521
Published: 15 March 2007
View articletitled, Accelerated Notch-Dependent Degradation of E47 Proteins in Aged B Cell Precursors Is Associated with Increased ERK MAPK Activation
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Journal Articles

RNA Stability of the E2A-Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice

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Daniela Frasca, Elaine Van der Put, Ana Marie Landin, Dapeng Gong, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2005) 175 (10): 6633–6644.
https://doi.org/10.4049/jimmunol.175.10.6633
Published: 15 November 2005
View articletitled, RNA Stability of the E2A-Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice
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Journal Articles

Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover

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Elaine Van der Put, Daniela Frasca, Anne M. King, Bonnie B. Blomberg, Richard L. Riley
Journal: The Journal of Immunology
J Immunol (2004) 173 (2): 818–827.
https://doi.org/10.4049/jimmunol.173.2.818
Published: 15 July 2004
View articletitled, Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover
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Journal Articles

Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase

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Daniela Frasca, Elaine Van der Put, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2004) 172 (4): 2155–2162.
https://doi.org/10.4049/jimmunol.172.4.2155
Published: 15 February 2004
View articletitled, Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase
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Journal Articles

Decreased E12 and/or E47 Transcription Factor Activity in the Bone Marrow As Well As in the Spleen of Aged Mice

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Daniela Frasca, Diep Nguyen, Richard L. Riley, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2003) 170 (2): 719–726.
https://doi.org/10.4049/jimmunol.170.2.719
Published: 15 January 2003
View articletitled, Decreased E12 and/or E47 Transcription Factor Activity in the Bone Marrow As Well As in the Spleen of Aged Mice
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Journal Articles

Transgenic Human λ5 Rescues the Murine λ5 Nullizygous Phenotype

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Mary E. Donohoe, Gabriele B. Beck-Engeser, Nils Lonberg, Hajime Karasuyama, Richard L. Riley, Hans-Martin Jäck, Bonnie B. Blomberg
Journal: The Journal of Immunology
J Immunol (2000) 164 (10): 5269–5276.
https://doi.org/10.4049/jimmunol.164.10.5269
Published: 15 May 2000
View articletitled, Transgenic Human λ5 Rescues the Murine λ5 Nullizygous Phenotype
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Journal Articles

Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment

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Erin M. Sherwood, Bonnie B. Blomberg, Wei Xu, Cynthia A. Warner, Richard L. Riley
Journal: The Journal of Immunology
J Immunol (1998) 161 (9): 4472–4475.
https://doi.org/10.4049/jimmunol.161.9.4472
Published: 01 November 1998
View articletitled, Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment
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Journal Articles

The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity.

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M E Donohoe, B B Blomberg
Journal: The Journal of Immunology
J Immunol (1997) 158 (4): 1681–1691.
https://doi.org/10.4049/jimmunol.158.4.1681
Published: 15 February 1997
View articletitled, The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity.
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Journal Articles

Identification and localization of a developmental stage-specific promoter activity from the murine lambda 5 gene.

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J Yang, M A Glozak, B B Blomberg
Journal: The Journal of Immunology
J Immunol (1995) 155 (5): 2498–2514.
https://doi.org/10.4049/jimmunol.155.5.2498
Published: 01 September 1995
View articletitled, Identification and localization of a developmental stage-specific promoter activity from the murine lambda 5 gene.
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