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Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products

Gautam Sethi, Kwang Seok Ahn, Dianren Xia, Jonathan M. Kurie, Bharat B. Aggarwal

J Immunol (2007) 179 (3): 1926–1933.

DOI: https://doi.org/10.4049/jimmunol.179.3.1926

Published: 01 August 2007

View article titled, Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products

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A Previously Unrecognized Protein-Protein Interaction between TWEAK and CD163: Potential Biological Implications

Laura C. Bover, Marina Cardó-Vila, Akihiko Kuniyasu, Jessica Sun, Roberto Rangel, Motohiro Takeya, Bharat B. Aggarwal, Wadih Arap, Renata Pasqualini

J Immunol (2007) 178 (12): 8183–8194.

DOI: https://doi.org/10.4049/jimmunol.178.12.8183

Published: 15 June 2007

View article titled, A Previously Unrecognized Protein-Protein Interaction between TWEAK and CD163: Potential Biological Implications

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Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1

Kwang Seok Ahn, Gautam Sethi, Bharat B. Aggarwal

J Immunol (2007) 178 (4): 2507–2516.

DOI: https://doi.org/10.4049/jimmunol.178.4.2507

Published: 15 February 2007

View article titled, Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1

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Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion

Asha S. Nair, Shishir Shishodia, Kwang Seok Ahn, Ajaikumar B. Kunnumakkara, Gautam Sethi, Bharat B. Aggarwal

J Immunol (2006) 177 (8): 5612–5622.

DOI: https://doi.org/10.4049/jimmunol.177.8.5612

Published: 15 October 2006

View article titled, Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion

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Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression

Yasunari Takada, Haruyo Ichikawa, Vladimir Badmaev, Bharat B. Aggarwal

J Immunol (2006) 176 (5): 3127–3140.

DOI: https://doi.org/10.4049/jimmunol.176.5.3127

Published: 01 March 2006

View article titled, Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression

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Identification of a Novel Blocker of IκBα Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-κB-Regulated Gene Products

Haruyo Ichikawa, Yasunari Takada, Akira Murakami, Bharat B. Aggarwal

J Immunol (2005) 174 (11): 7383–7392.

DOI: https://doi.org/10.4049/jimmunol.174.11.7383

Published: 01 June 2005

View article titled, Identification of a Novel Blocker of IκBα Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-κB-Regulated Gene Products

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Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF

Sita Aggarwal, Yasunari Takada, Abner M. Mhashilkar, Kerry Sieger, Sunil Chada, Bharat B. Aggarwal

J Immunol (2004) 173 (7): 4368–4376.

DOI: https://doi.org/10.4049/jimmunol.173.7.4368

Published: 01 October 2004

View article titled, Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF

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Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis

Shishir Shishodia, Dimpy Koul, Bharat B. Aggarwal

J Immunol (2004) 173 (3): 2011–2022.

DOI: https://doi.org/10.4049/jimmunol.173.3.2011

Published: 01 August 2004

View article titled, Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis

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TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis

Yasunari Takada, Bharat B. Aggarwal

J Immunol (2004) 173 (2): 1066–1077.

DOI: https://doi.org/10.4049/jimmunol.173.2.1066

Published: 15 July 2004

View article titled, TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis

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Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis

Alok C. Bharti, Yasunari Takada, Bharat B. Aggarwal

J Immunol (2004) 172 (10): 5940–5947.

DOI: https://doi.org/10.4049/jimmunol.172.10.5940

Published: 15 May 2004

View article titled, Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis

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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

Alok C. Bharti, Nicholas Donato, Bharat B. Aggarwal

J Immunol (2003) 171 (7): 3863–3871.

DOI: https://doi.org/10.4049/jimmunol.171.7.3863

Published: 01 October 2003

View article titled, Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

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Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9

Yasunari Takada, Bharat B. Aggarwal

J Immunol (2003) 171 (6): 3278–3286.

DOI: https://doi.org/10.4049/jimmunol.171.6.3278

Published: 15 September 2003

View article titled, Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9

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Journal Articles

Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation

Kazuhiro Ashikawa, Sekhar Majumdar, Sanjeev Banerjee, Alok C. Bharti, Shishir Shishodia, Bharat B. Aggarwal

J Immunol (2002) 169 (11): 6490–6497.

DOI: https://doi.org/10.4049/jimmunol.169.11.6490

Published: 01 December 2002

View article titled, Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation

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Journal Articles

Thalidomide Suppresses NF-κB Activation Induced by TNF and H₂O₂, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester

Sekhar Majumdar, Betty Lamothe, Bharat B. Aggarwal

J Immunol (2002) 168 (6): 2644–2651.

DOI: https://doi.org/10.4049/jimmunol.168.6.2644

Published: 15 March 2002

View article titled, Thalidomide Suppresses NF-κB Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester

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Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

Sekhar Majumdar, Bharat B. Aggarwal

J Immunol (2001) 167 (5): 2911–2920.

DOI: https://doi.org/10.4049/jimmunol.167.5.2911

Published: 01 September 2001

View article titled, Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

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Journal Articles

Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis

Sunil K. Manna, Asok Mukhopadhyay, Bharat B. Aggarwal

J Immunol (2000) 165 (10): 5962–5969.

DOI: https://doi.org/10.4049/jimmunol.165.10.5962

Published: 15 November 2000

View article titled, Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis

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Journal Articles

IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis

Sunil K. Manna, Asok Mukhopadhyay, Bharat B. Aggarwal

J Immunol (2000) 165 (9): 4927–4934.

DOI: https://doi.org/10.4049/jimmunol.165.9.4927

Published: 01 November 2000

View article titled, IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis

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Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation

Sunil K. Manna, Asok Mukhopadhyay, Bharat B. Aggarwal

J Immunol (2000) 164 (12): 6509–6519.

DOI: https://doi.org/10.4049/jimmunol.164.12.6509

Published: 15 June 2000

View article titled, Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation

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Journal Articles

Vesnarinone Suppresses TNF-Induced Activation of NF-κB, c-Jun Kinase, and Apoptosis

Sunil K. Manna, Bharat B. Aggarwal

J Immunol (2000) 164 (11): 5815–5825.

DOI: https://doi.org/10.4049/jimmunol.164.11.5815

Published: 01 June 2000

View article titled, Vesnarinone Suppresses TNF-Induced Activation of NF-κB, c-Jun Kinase, and Apoptosis

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Journal Articles

Differential Requirement for p56^lck in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis

Sunil K. Manna, Bharat B. Aggarwal

J Immunol (2000) 164 (10): 5156–5166.

DOI: https://doi.org/10.4049/jimmunol.164.10.5156

Published: 15 May 2000

View article titled, Differential Requirement for p56lck in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis

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NARROW

Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products

A Previously Unrecognized Protein-Protein Interaction between TWEAK and CD163: Potential Biological Implications

Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1

Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion

Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression

Identification of a Novel Blocker of IκBα Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-κB-Regulated Gene Products

Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis

TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis

Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9

Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation

Thalidomide Suppresses NF-κB Activation Induced by TNF and H₂O₂, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester

Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis

IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis

Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation

Vesnarinone Suppresses TNF-Induced Activation of NF-κB, c-Jun Kinase, and Apoptosis

Differential Requirement for p56^lck in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis

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