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Brian V. Geisbrecht
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Journal Articles

Group B Streptococcus Surface Protein β: Structural Characterization of a Complement Factor H–Binding Motif and Its Contribution to Immune Evasion

Xin Xu, Alexander L. Lewis Marffy, Andrew Keightley, Alex J. McCarthy, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2022) 208 (5): 1232–1247.
https://doi.org/10.4049/jimmunol.2101078
Published: 01 March 2022
View article titled, Group B <em>Streptococcus</em> Surface Protein β: Structural Characterization of a Complement Factor H–Binding Motif and Its Contribution to Immune Evasion
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Includes: Supplementary data
Journal Articles

Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B

Xin Xu, Chi Zhang, Dahlia T. Denton, Daniel O’Connell, Daniel W. Drolet, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2021) 206 (4): 861–873.
https://doi.org/10.4049/jimmunol.2001260
Published: 15 February 2021
View article titled, Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B
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Journal Articles

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics

Brandon L. Garcia, D. Andrew Skaff, Arindam Chatterjee, Anders Hanning, John K. Walker, Gerald J. Wyckoff, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2017) 198 (9): 3705–3718.
https://doi.org/10.4049/jimmunol.1601932
Published: 01 May 2017
View article titled, Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics
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Includes: Supplementary data
Journal Articles

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b

Malvina Papanastasiou, Sophia Koutsogiannaki, Yiannis Sarigiannis, Brian V. Geisbrecht, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3326–3335.
https://doi.org/10.4049/jimmunol.1601864
Published: 15 April 2017
View article titled, Structural Implications for the Formation and Function of the Complement Effector Protein iC3b
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Includes: Supplementary data
Journal Articles

Novel Evasion Mechanisms of the Classical Complement Pathway

In Special Collection:
Brief Reviews
Brandon L. Garcia, Seline A. Zwarthoff, Suzan H. M. Rooijakkers, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2016) 197 (6): 2051–2060.
https://doi.org/10.4049/jimmunol.1600863
Published: 15 September 2016
View article titled, Novel Evasion Mechanisms of the Classical Complement Pathway
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Journal Articles

Attenuation of Staphylococcus aureus–Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

Maria Georgoutsou-Spyridonos, Daniel Ricklin, Haris Pratsinis, Eustathia Perivolioti, Ioannis Pirmettis, Brandon L. Garcia, Brian V. Geisbrecht, Periklis G. Foukas, John D. Lambris, Dimitrios C. Mastellos, Georgia Sfyroera
Journal: The Journal of Immunology
J Immunol (2015) 195 (8): 3946–3958.
https://doi.org/10.4049/jimmunol.1500966
Published: 15 October 2015
View article titled, Attenuation of <em>Staphylococcus aureus–</em>Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb
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Includes: Supplementary data
Journal Articles

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase

Jordan L. Woehl, Daphne A. C. Stapels, Brandon L. Garcia, Kasra X. Ramyar, Andrew Keightley, Maartje Ruyken, Maria Syriga, Georgia Sfyroera, Alexander B. Weber, Michal Zolkiewski, Daniel Ricklin, John D. Lambris, Suzan H. M. Rooijakkers, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2014) 193 (12): 6161–6171.
https://doi.org/10.4049/jimmunol.1401600
Published: 15 December 2014
View article titled, The Extracellular Adherence Protein from <em>Staphylococcus aureus</em> Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
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Includes: Supplementary data
Journal Articles

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

Daniel Ricklin, Apostolia Tzekou, Brandon L. Garcia, Michal Hammel, William J. McWhorter, Georgia Sfyroera, You-Qiang Wu, V. Michael Holers, Andrew P. Herbert, Paul N. Barlow, Brian V. Geisbrecht, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2009) 183 (4): 2565–2574.
https://doi.org/10.4049/jimmunol.0901443
Published: 15 August 2009
View article titled, A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family
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Includes: Supplementary data
Journal Articles

Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2

Daniel Ricklin, Salome K. Ricklin-Lichtsteiner, Maciej M. Markiewski, Brian V. Geisbrecht, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 7463–7467.
https://doi.org/10.4049/jimmunol.181.11.7463
Published: 01 December 2008
View article titled, Cutting Edge: Members of the <em>Staphylococcus aureus</em> Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2
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