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Bruce R. Blazar
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Journal Articles

Disruption of IL-33-mediated costimulation to CD4 +T cells leads to peripheral Treg generation and resolution of T cell-mediated pathology

Gaelen K Dwyer, Lisa Mathews, Amanda H Lee, Johnny Bou Saba, Harshita Beeravolu, Jose A Villegas Vazquez, Amanda Poholek, Bruce R Blazar, Sanjiv A Luther, Warren D Shlomchik, Heth Roderick Turnquist
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 76.12.
https://doi.org/10.4049/jimmunol.210.Supp.76.12
Published: 01 May 2023
View article titled, Disruption of IL-33-mediated costimulation to CD4 <sup>+</sup>T cells leads to peripheral Treg generation and resolution of T cell-mediated pathology
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Human CAR19 CD8 +iTreg exceed CAR19 CD8 CTLs both in suppressing GVHD lethality and eliminating CD19 +Nalm-6 lymphoma cells in vivo

Jemma H Larson, Ewoud B Compeer, Mehrdad Hefazi Torghabeh, Kyle D Smith, Sujeong Jin, Phillip Dougherty, Cameron McDonald-Hyman, Bailey Houle, Michael Dustin, Keli L Hippen, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 173.12.
https://doi.org/10.4049/jimmunol.210.Supp.173.12
Published: 01 May 2023
View article titled, Human CAR19 CD8 <sup>+</sup>iTreg exceed CAR19 CD8 CTLs both in suppressing GVHD lethality and eliminating CD19 <sup>+</sup>Nalm-6 lymphoma cells <em>in vivo</em>
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Retention of epigenetic and transcriptional memory among reprogrammed T cells (T-iPSCs) imparts selective advantage for T cell re-differentiation.

Robin L Williams, Alyssa Morrow, Jeremy Allred, Jakub Tolar, W. Nicholas Haining, Nir Yosef, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 107.12.
https://doi.org/10.4049/jimmunol.208.Supp.107.12
Published: 01 May 2022
View article titled, Retention of epigenetic and transcriptional memory among reprogrammed T cells (T-iPSCs) imparts selective advantage for T cell re-differentiation.
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Journal Articles

IL-33 upregulated in fibroblastic reticular cells after recipient conditioning acts as a novel costimulatory signal in the generation of alloreactive Type 1 T helper cells

Gaelen K Dwyer, Lisa Mathews, Anna Lucas, Bruce R Blazar, Amanda Poholek, Warren Shlomchik, Heth Roderick Turnquist
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 175.08.
https://doi.org/10.4049/jimmunol.208.Supp.175.08
Published: 01 May 2022
View article titled, IL-33 upregulated in fibroblastic reticular cells after recipient conditioning acts as a novel costimulatory signal in the generation of alloreactive Type 1 T helper cells
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Augmenting oxidation of branched-chain amino acids (BCAAs) treats murine chronic Graft-Versus-Host Disease (cGVHD)

Sujeong Jin, Sara Bolivar Wagers, Kirsti L Walker, Emily T Mirek, Peter T Sage, Zoltan Arany, Tracy G Anthony, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 175.19.
https://doi.org/10.4049/jimmunol.208.Supp.175.19
Published: 01 May 2022
View article titled, Augmenting oxidation of branched-chain amino acids (BCAAs) treats murine chronic Graft-Versus-Host Disease (cGVHD)
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Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor

Fathima A. Mohamed, Stephanie Y Rhee, Joanna Ly, Ethan G Aguilar, Peter T Sage, Tanner Schumacher, Govindarajan Thangavelu, Michael C Zaiken, Juan Liu, Venkatram Mereddy, Jason W Locasale, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 175.25.
https://doi.org/10.4049/jimmunol.208.Supp.175.25
Published: 01 May 2022
View article titled, Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor
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Targeted gastrointestinal tract homing of regulatory T-cells reduces acute graft-versus-host disease severity by simulating an increase in Treg dose in vivo

Jemma H Nicholls, Michael Loschi, Sujeong Jin, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G Aguliar, Brent Koehn, Mark J Osborn, Kelli P.A. MacDonald, Sangwon V Kim, Dan R Littman, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 11.05.
https://doi.org/10.4049/jimmunol.206.Supp.11.05
Published: 01 May 2021
View article titled, Targeted gastrointestinal tract homing of regulatory T-cells reduces acute graft-versus-host disease severity by simulating an increase in Treg dose <em>in vivo</em>
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Journal Articles

IL-33 is a critical early activation and differentiation signal for alloreactive CD4+ T cells that enables their infiltration into GVHD target tissues

Gaelen K Dwyer, Lisa Mathews, Anna Lucas, Bruce R Blazar, Warren Shlomchik, Heth Roderick Turnquist
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 28.06.
https://doi.org/10.4049/jimmunol.206.Supp.28.06
Published: 01 May 2021
View article titled, IL-33 is a critical early activation and differentiation signal for alloreactive CD4<sup>+</sup> T cells that enables their infiltration into GVHD target tissues
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Journal Articles

In vitro expanded human regulatory T cells (tTreg) and CD4+ effector T cells (Teff) display distinct metabolic demands and response to lactate.

Keli L Hippen, Yigang Zhang, Ethan George Aguilar, Stephanie Rhee, Sara Bolivar Wagers, Roderick O‘Connor, Jeffrey C Rathmell, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 66.08.
https://doi.org/10.4049/jimmunol.206.Supp.66.08
Published: 01 May 2021
View article titled, In vitro expanded human regulatory T cells (tTreg) and CD4+ effector T cells (Teff) display distinct metabolic demands and response to lactate.
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Journal Articles

Divergent roles of retinoic acid signaling in T regulatory cell function

Govindarajan Thangavelu, Gabriela Andrejeva, Michael Loschi, Ethan G Aguilar, Yu-Chi Lee, Scott N Furlan, Cameron McDonald-Hyman, Michael C Zaiken, Colby J Feser, Angela Panoskaltsis-Mortari, Leslie S Kean, Jeffrey C Rathmell, Hongbo Chi, Randolph J Noelle, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 228.4.
https://doi.org/10.4049/jimmunol.204.Supp.228.4
Published: 01 May 2020
View article titled, Divergent roles of retinoic acid signaling in T regulatory cell function
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PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease

Stephanie Rhee, Ethan George Aguilar, Katelyn Paz, Ryan Flynn, Juhi Kuchroo, Peter Sage, Arlene H Sharpe, Gordon J Freeman, Rafi Ahmed, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.8.
https://doi.org/10.4049/jimmunol.204.Supp.87.8
Published: 01 May 2020
View article titled, PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease
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Journal Articles

Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)

Ethan George Aguilar, Stephanie Rhee, Govindarajan Thangavelu, Michael Loschi, Katelyn Paz, Asim Saha, Joanna Ly, Peter Sage, Arlene H Sharpe, Ivan Maillard, William J Murphy, Jonathan S Serody, Suji Jin, Sara Bolivar Wagers, Jemma Nicholls, Geoffrey Hill, Kelli PA MacDonald, Ewoud Compeer, Michael Dustin, Roddy O’Connor, Tim Sparwasser, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.2.
https://doi.org/10.4049/jimmunol.204.Supp.87.2
Published: 01 May 2020
View article titled, Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)
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Journal Articles

GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells

Eric Perkey, Dave Maurice De Sousa, Léolène Carrington, Jooho Chung, Alexander Dils, David Granadier, Ute Koch, Freddy Radtke, Burkhard Ludewig, Bruce R. Blazar, Christian W. Siebel, Todd V. Brennan, Jeffrey Nolz, Nathalie Labrecque, Ivan Maillard
Journal: The Journal of Immunology
J Immunol (2020) 204 (6): 1674–1688.
https://doi.org/10.4049/jimmunol.1901194
Published: 15 March 2020
View article titled, GCNT1-Mediated <em>O</em>-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells
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Includes: Supplementary data
Journal Articles

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease

Jooho Chung, Vedran Radojcic, Eric Perkey, Timothy J. Parnell, Yashar Niknafs, Xi Jin, Ann Friedman, Nathalie Labrecque, Bruce R. Blazar, Todd V. Brennan, Christian W. Siebel, Ivan Maillard
Journal: The Journal of Immunology
J Immunol (2019) 203 (2): 557–568.
https://doi.org/10.4049/jimmunol.1900192
Published: 15 July 2019
View article titled, Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4<sup>+</sup> T Cells in Graft-versus-Host Disease
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Includes: Supplementary data
Journal Articles

The fate of leukemia-specific CD8+ T cell clones is dictated by antigen specificity and the mechanism of cognate antigen presentation

Xiufen Chen, Blake Flood, Brendan MacNabb, Bruce R. Blazar, Justin Kline
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 135.6.
https://doi.org/10.4049/jimmunol.202.Supp.135.6
Published: 01 May 2019
View article titled, The fate of leukemia-specific CD8<sup>+</sup> T cell clones is dictated by antigen specificity and the mechanism of cognate antigen presentation
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Virus-specific memory T cells populate tumors and can be repurposed as a tumor immunotherapy

Pamela Rosato, Sathi Wijeyesinghe, Michael Stolley, Christine Nelson, Rachel L Davis, Luke S Manlove, Christopher A Pennell, Bruce R. Blazar, Clark C Chen, Melissa A Geller, Vaiva Vezys, David Masopust
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 194.6.
https://doi.org/10.4049/jimmunol.202.Supp.194.6
Published: 01 May 2019
View article titled, Virus-specific memory T cells populate tumors and can be repurposed as a tumor immunotherapy
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Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation

Michael C Zaiken, Ryan Flynn, Katelyn Paz, Stephanie Rhee, Paul Park, Matthew Hemming, Peter Sage, Arlene Sharpe, Leonard Luznik, Ivan Mailard, Geoffrey R. Hill, Kelli MacDonald, Jonathon Serody, Corey Cutler, John Koreth, David Miklos, Joseph Antin, Robert Soiffer, Jerome Ritz, Jay Bradner, Jun Qi, Bruce R. Blazar
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 69.42.
https://doi.org/10.4049/jimmunol.202.Supp.69.42
Published: 01 May 2019
View article titled, Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation
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Journal Articles

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

Motoko Koyama, Pamela Mukhopadhyay, Iona S Schuster, Andrea S Henden, Jan Hülsdünker, Antiopi Varelias, Marie Vetizou, Rachel D Kuns, Renee J Robb, Ping Zhang, Bruce R. Blazar, Ranjeny Thomas, Jakob Begun, Nicola Waddell, Giorgio Trinchieri, Robert Zeiser, Andrew D Clouston, Mariapia A Degli-Esposti, Geoffrey R. Hill
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 69.38.
https://doi.org/10.4049/jimmunol.202.Supp.69.38
Published: 01 May 2019
View article titled, Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology
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IL-33 signaling in the barrier tissues sustains alloimmune responses mediating graft vs. host disease

Gaelen K Dwyer, Lisa Mathews, Anna Lucas, Bruce R. Blazar, Heth R Turnquist
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 69.35.
https://doi.org/10.4049/jimmunol.202.Supp.69.35
Published: 01 May 2019
View article titled, IL-33 signaling in the barrier tissues sustains alloimmune responses mediating graft vs. host disease
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B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality

Asim Saha, Patricia A. Taylor, Christopher J. Lees, Angela Panoskaltsis-Mortari, Mark J. Osborn, Colby J. Feser, Govindarajan Thangavelu, Wolfgang Melchinger, Yosef Refaeli, Geoffrey R. Hill, David H. Munn, Jonathan S. Serody, Ivan Maillard, Katharina Kreymborg, Marcel van den Brink, Chen Dong, Shuyu Huang, Xingxing Zang, James P Allison, Robert Zeiser, Bruce R. Blazar
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 69.10.
https://doi.org/10.4049/jimmunol.202.Supp.69.10
Published: 01 May 2019
View article titled, B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality
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