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Daniel Ricklin
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Journal Articles

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b

Malvina Papanastasiou, Sophia Koutsogiannaki, Yiannis Sarigiannis, Brian V. Geisbrecht, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3326–3335.
https://doi.org/10.4049/jimmunol.1601864
Published: 15 April 2017
View article titled, Structural Implications for the Formation and Function of the Complement Effector Protein iC3b
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Includes: Supplementary data
Journal Articles

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

Adam Z. Blatt, Gurpanna Saggu, Koustubh V. Kulkarni, Claudio Cortes, Joshua M. Thurman, Daniel Ricklin, John D. Lambris, Jesus G. Valenzuela, Viviana P. Ferreira
Journal: The Journal of Immunology
J Immunol (2016) 196 (11): 4671–4680.
https://doi.org/10.4049/jimmunol.1600040
Published: 01 June 2016
View article titled, Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood
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Includes: Supplementary data
Journal Articles

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

Markus J. Harder, Markus Anliker, Britta Höchsmann, Thomas Simmet, Markus Huber-Lang, Hubert Schrezenmeier, Daniel Ricklin, John D. Lambris, Paul N. Barlow, Christoph Q. Schmidt
Journal: The Journal of Immunology
J Immunol (2016) 196 (2): 866–876.
https://doi.org/10.4049/jimmunol.1501919
Published: 15 January 2016
View article titled, Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation
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Includes: Supplementary data
Journal Articles

Attenuation of Staphylococcus aureus–Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

Maria Georgoutsou-Spyridonos, Daniel Ricklin, Haris Pratsinis, Eustathia Perivolioti, Ioannis Pirmettis, Brandon L. Garcia, Brian V. Geisbrecht, Periklis G. Foukas, John D. Lambris, Dimitrios C. Mastellos, Georgia Sfyroera
Journal: The Journal of Immunology
J Immunol (2015) 195 (8): 3946–3958.
https://doi.org/10.4049/jimmunol.1500966
Published: 15 October 2015
View article titled, Attenuation of <em>Staphylococcus aureus–</em>Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb
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Includes: Supplementary data
Journal Articles

The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase (INM8P.361)

Jordan Woehl, Daphne Stapels, Brandon Garcia, Kasra Ramyar, Andrew Keightley, Maartje Ruyken, Georgia Sfyroera, Alexander Weber, Michal Zolkiewski, Daniel Ricklin, John Lambris, Suzan Rooijakkers, Brian Geisbrecht
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 195.5.
https://doi.org/10.4049/jimmunol.194.Supp.195.5
Published: 01 May 2015
View article titled, The extracellular adherence protein from <em>Staphylococcus aureus </em>inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase (INM8P.361)
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Journal Articles

Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity

Georgia Sfyroera, Daniel Ricklin, Edimara S. Reis, Hui Chen, Emilia L. Wu, Yiannis N. Kaznessis, Kristina N. Ekdahl, Bo Nilsson, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2015) 194 (7): 3305–3316.
https://doi.org/10.4049/jimmunol.1402781
Published: 01 April 2015
View article titled, Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity
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Includes: Supplementary data
Journal Articles

Complement Deficiency Promotes Cutaneous Wound Healing in Mice

Stavros Rafail, Ioannis Kourtzelis, Periklis G. Foukas, Maciej M. Markiewski, Robert A. DeAngelis, Mara Guariento, Daniel Ricklin, Elizabeth A. Grice, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2015) 194 (3): 1285–1291.
https://doi.org/10.4049/jimmunol.1402354
Published: 01 February 2015
View article titled, Complement Deficiency Promotes Cutaneous Wound Healing in Mice
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Journal Articles

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase

Jordan L. Woehl, Daphne A. C. Stapels, Brandon L. Garcia, Kasra X. Ramyar, Andrew Keightley, Maartje Ruyken, Maria Syriga, Georgia Sfyroera, Alexander B. Weber, Michal Zolkiewski, Daniel Ricklin, John D. Lambris, Suzan H. M. Rooijakkers, Brian V. Geisbrecht
Journal: The Journal of Immunology
J Immunol (2014) 193 (12): 6161–6171.
https://doi.org/10.4049/jimmunol.1401600
Published: 15 December 2014
View article titled, The Extracellular Adherence Protein from <em>Staphylococcus aureus</em> Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
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Includes: Supplementary data
Journal Articles

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, Kavita B. Hosur, Robert A. DeAngelis, Daniel Ricklin, John D. Lambris, George Hajishengallis
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 6020–6027.
https://doi.org/10.4049/jimmunol.1400569
Published: 15 June 2014
View article titled, Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis
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Includes: Supplementary data
Journal Articles

Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14

Katerina Oikonomopoulou, Robert A. DeAngelis, Hui Chen, Eleftherios P. Diamandis, Morley D. Hollenberg, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2013) 191 (7): 3858–3866.
https://doi.org/10.4049/jimmunol.1202999
Published: 01 October 2013
View article titled, Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14
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Includes: Supplementary data
Journal Articles

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

Christoph Q. Schmidt, Hongjun Bai, Zhuoer Lin, Antonio M. Risitano, Paul N. Barlow, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2013) 190 (11): 5712–5721.
https://doi.org/10.4049/jimmunol.1203548
Published: 01 June 2013
View article titled, Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties
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Includes: Supplementary data
Journal Articles

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

In Special Collection:
Brief Reviews
Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2013) 190 (8): 3839–3847.
https://doi.org/10.4049/jimmunol.1203200
Published: 15 April 2013
View article titled, Complement in Immune and Inflammatory Disorders: Therapeutic Interventions
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Journal Articles

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

In Special Collection:
Brief Reviews
Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2013) 190 (8): 3831–3838.
https://doi.org/10.4049/jimmunol.1203487
Published: 15 April 2013
View article titled, Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
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Journal Articles

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

Toshiharu Abe, Kavita B. Hosur, Evlambia Hajishengallis, Edimara S. Reis, Daniel Ricklin, John D. Lambris, George Hajishengallis
Journal: The Journal of Immunology
J Immunol (2012) 189 (11): 5442–5448.
https://doi.org/10.4049/jimmunol.1202339
Published: 01 December 2012
View article titled, Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist
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Journal Articles

C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay

Edimara S. Reis, Hui Chen, Georgia Sfyroera, Peter N. Monk, Jörg Köhl, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2012) 189 (10): 4797–4805.
https://doi.org/10.4049/jimmunol.1200834
Published: 15 November 2012
View article titled, C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay
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Includes: Supplementary data
Journal Articles

Correction: Protection of nonself surfaces from complement attack by factor h-binding peptides: implications for therapeutic medicine

You-Qiang Wu, Hongchang Qu, Georgia Sfyroera, Apostolia Tzekou, Brian K. Kay, Bo Nilsson, Kristina Nilsson Ekdahl, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2012) 188 (12): 6425.
https://doi.org/10.4049/jimmunol.1290027
Published: 15 June 2012
View article titled, Correction: Protection of nonself surfaces from complement attack by factor h-binding peptides: implications for therapeutic medicine
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Journal Articles

Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine

You-Qiang Wu, Hongchang Qu, Georgia Sfyroera, Apostolia Tzekou, Brian K. Kay, Bo Nilsson, Kristina Nilsson Ekdahl, Daniel Ricklin, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2011) 186 (7): 4269–4277.
https://doi.org/10.4049/jimmunol.1003802
Published: 01 April 2011
View article titled, Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine
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Includes: Supplementary data
Journal Articles

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

Daniel Ricklin, Apostolia Tzekou, Brandon L. Garcia, Michal Hammel, William J. McWhorter, Georgia Sfyroera, You-Qiang Wu, V. Michael Holers, Andrew P. Herbert, Paul N. Barlow, Brian V. Geisbrecht, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2009) 183 (4): 2565–2574.
https://doi.org/10.4049/jimmunol.0901443
Published: 15 August 2009
View article titled, A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family
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Includes: Supplementary data
Journal Articles

Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2

Daniel Ricklin, Salome K. Ricklin-Lichtsteiner, Maciej M. Markiewski, Brian V. Geisbrecht, John D. Lambris
Journal: The Journal of Immunology
J Immunol (2008) 181 (11): 7463–7467.
https://doi.org/10.4049/jimmunol.181.11.7463
Published: 01 December 2008
View article titled, Cutting Edge: Members of the <em>Staphylococcus aureus</em> Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2
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