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David B. Weiner
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Journal Articles

Mucosal chemokine adjuvant supports heterologous protection against Delta and Omicron VOCs in the context of a SARS-CoV-2 wild-type DNA vaccine

In Special Collection:
COVID-19, SARS, and MERS Articles
Ebony Nicole Gary, Nicholas J Tursi, Bryce M Warner, Elizabeth M Parzych, Ali R Ali, Drew Frase, Estella Moffat, Carissa Embury-Hyatt, Trevor RF Smith, Kate E broderick, Laurent Humeau, Darwyn KobasA, Ami Patel, Daniel W Kulp, David B Weiner
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 253.15.
https://doi.org/10.4049/jimmunol.210.Supp.253.15
Published: 01 May 2023
View article titled, Mucosal chemokine adjuvant supports heterologous protection against Delta and Omicron VOCs in the context of a SARS-CoV-2 wild-type DNA vaccine
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Journal Articles

Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

In Special Collection:
COVID-19, SARS, and MERS Articles
Gina Cusimano, Ebony N. Gary, Nicholas J Tursi, Bryce M Warner, Jennifer Connors, Elizabeth M Parzych, Bryan D. Griffin, Matthew Bell, Ali R Ali, Drew Frase, Casey Hojecki, Gabriela Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah Wootton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A. Kutzler, Elias Haddad, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 252.04.
https://doi.org/10.4049/jimmunol.210.Supp.252.04
Published: 01 May 2023
View article titled, Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge
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Journal Articles

Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1

In Special Collection:
COVID-19, SARS, and MERS Articles
Gina M. Cusimano, Ebony N. Gary, Matthew R. Bell, Bryce M. Warner, Jennifer Connors, Nicholas J. Tursi, Ali R. Ali, Shiyu Zhang, Gabriela Canziani, Bhavani Taramangalam, Emma A. Gordon, Irwin M. Chaiken, Sarah K. Wootton, Trevor Smith, Stephanie Ramos, Darwyn Kobasa, David B. Weiner, Michele A. Kutzler, Elias K. Haddad
Journal: The Journal of Immunology
J Immunol (2022) 209 (1): 118–127.
https://doi.org/10.4049/jimmunol.2200056
Published: 01 July 2022
View article titled, Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1
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Includes: Supplementary data
Journal Articles

Peripheral co-immunization with CCL27 drives robust mucosal responses to SARS-CoV-2 synDNA antigens and provides heterologous protection against Delta variant challenge

In Special Collection:
COVID-19, SARS, and MERS Articles
Ebony Nicole Gary, Nicholas J Tursi, Bryce Warner, Elizabeth Parzych, Ali Ali, Darwyn Kobasa, Ami Patel, Daniel Kulp, David B Weiner
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 65.02.
https://doi.org/10.4049/jimmunol.208.Supp.65.02
Published: 01 May 2022
View article titled, Peripheral co-immunization with CCL27 drives robust mucosal responses to SARS-CoV-2 synDNA antigens and provides heterologous protection against Delta variant challenge
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Journal Articles

Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms

Adam McNee, Trevor R. F. Smith, Barbara Holzer, Becky Clark, Emily Bessell, Ghiabe Guibinga, Heather Brown, Katherine Schultheis, Paul Fisher, Stephanie Ramos, Alejandro Nunez, Matthieu Bernard, Simon Graham, Veronica Martini, Tiphany Chrun, Yongli Xiao, John C. Kash, Jeffery K. Taubenberger, Sarah Elliott, Ami Patel, Peter Beverley, Pramila Rijal, David B. Weiner, Alain Townsend, Kate E. Broderick, Elma Tchilian
Journal: The Journal of Immunology
J Immunol (2020) 205 (3): 648–660.
https://doi.org/10.4049/jimmunol.2000429
Published: 01 August 2020
View article titled, Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms
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Journal Articles

Vaccination against Follicle Stimulating Hormone Receptor delays ovarian cancer progression by breaking immune tolerance

Alfredo Perales Puchalt, Kryzstof Wojtak, Elizabeth K. Duperret, Jian Yan, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 181.1.
https://doi.org/10.4049/jimmunol.200.Supp.181.1
Published: 01 May 2018
View article titled, Vaccination against Follicle Stimulating Hormone Receptor delays ovarian cancer progression by breaking immune tolerance
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Journal Articles

Co-delivery of mucosa-associated epithelial chemokine (MEC/CCL28) enhances anti-HIV-1 mucosal responses through CCR10 in the context of DNA vaccination

Ebony Nicole Gary, Noshin Kathuria, Mariana Estrella Bernui, Laurent Humeau, David B. Weiner, Michele A. Kutzler
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 180.7.
https://doi.org/10.4049/jimmunol.200.Supp.180.7
Published: 01 May 2018
View article titled, Co-delivery of mucosa-associated epithelial chemokine (MEC/CCL28) enhances anti-HIV-1 mucosal responses through CCR10 in the context of DNA vaccination
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Journal Articles

Unprecedented short-term in vivo protection in mice with a single immunization of a DNA GP vaccine against heterologous mouse-adapted Ebola virus challenge

Ami Patel, Trina Racine, Emma L. Reuschel, Muthumani Karuppiah, Devon Shedlock, Jian Yan, Amir Khan, Kevin Tierney, Xiangguo Qiu, Gary P Kobinger, Niranjan Sardesai, David B Weiner
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 76.19.
https://doi.org/10.4049/jimmunol.196.Supp.76.19
Published: 01 May 2016
View article titled, Unprecedented short-term <em>in vivo</em> protection in mice with a single immunization of a DNA GP vaccine against heterologous mouse-adapted Ebola virus challenge
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Journal Articles

HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells

Karuppiah Muthumani, Devon J. Shedlock, Daniel K. Choo, Paolo Fagone, Omkar U. Kawalekar, Jonathan Goodman, Chaoran B. Bian, Aarti A. Ramanathan, Parikh Atman, Pablo Tebas, Michael A. Chattergoon, Andrew Y. Choo, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 2932–2943.
https://doi.org/10.4049/jimmunol.1100594
Published: 15 September 2011
View article titled, HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells
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Journal Articles

CD8+ Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4+ T Cell Proliferation that Contributes to Increased Viral Loads

Yvonne M. Mueller, Duc H. Do, Jean D. Boyer, Muhamuda Kader, Joseph J. Mattapallil, Mark G. Lewis, David B. Weiner, Peter D. Katsikis
Journal: The Journal of Immunology
J Immunol (2009) 183 (8): 5006–5012.
https://doi.org/10.4049/jimmunol.0900141
Published: 15 October 2009
View article titled, CD8<sup>+</sup> Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4<sup>+</sup> T Cell Proliferation that Contributes to Increased Viral Loads
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Journal Articles

Intramuscular delivery of a plasmid-encoded molecular adjuvant elicits immune responses at mucosal sites in a macaque model (39.51)

Kimberly Ann Schoenly, Michele A Kutzler, Neil J Cisper, Jian Yan, Amir S Khan, Ruxandra Draghia-Akli, Mark G Lewis, David B Weiner
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 39.51.
https://doi.org/10.4049/jimmunol.182.Supp.39.51
Published: 01 April 2009
View article titled, Intramuscular delivery of a plasmid-encoded molecular adjuvant elicits immune responses at mucosal sites in a macaque model (39.51)
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Journal Articles

Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques

Rabih Halwani, Jean D. Boyer, Bader Yassine-Diab, Elias K. Haddad, Tara M. Robinson, Sanjeev Kumar, Rose Parkinson, Ling Wu, Maninder K. Sidhu, Rebecca Phillipson-Weiner, George N. Pavlakis, Barbara K. Felber, Mark G. Lewis, Anding Shen, Robert F. Siliciano, David B. Weiner, Rafick-Pierre Sekaly
Journal: The Journal of Immunology
J Immunol (2008) 180 (12): 7969–7979.
https://doi.org/10.4049/jimmunol.180.12.7969
Published: 15 June 2008
View article titled, Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques
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Journal Articles

4-1BB antibody significantly enhances SIV-specific CD8+ T-cell immunity and proliferation following naked DNA vaccination in cynomolgus macaques (47.10)

David A Hokey, Lauren A. Hirao, Sandra A. Calarota, Jian Yan, Jean D. Boyer, Anlan Dai, Hanna Yoon, Maria N. Jure-Kunkel, Praveen Balimane, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S68.
https://doi.org/10.4049/jimmunol.178.Supp.47.10
Published: 01 April 2007
View article titled, 4-1BB antibody significantly enhances SIV-specific CD8+ T-cell immunity and proliferation following naked DNA vaccination in cynomolgus macaques (47.10)
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Journal Articles

Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help

Michele A. Kutzler, Tara M. Robinson, Michael A. Chattergoon, Daniel K. Choo, Andrew Y. Choo, Philip Y. Choe, Mathura P. Ramanathan, Rose Parkinson, Sagar Kudchodkar, Yutaka Tamura, Maninder Sidhu, Vidia Roopchand, J. Joseph Kim, George N. Pavlakis, Barbara K. Felber, Thomas A. Waldmann, Jean D. Boyer, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2005) 175 (1): 112–123.
https://doi.org/10.4049/jimmunol.175.1.112
Published: 01 July 2005
View article titled, Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help
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Journal Articles

Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86

Michael G. Agadjanyan, Michael A. Chattergoon, Mark J. Holterman, Behjatolah Monzavi-Karbassi, J. Joseph Kim, Tzvete Dentchev, Darren Wilson, Velpandi Ayyavoo, Luis J. Montaner, Thomas Kieber-Emmons, Rafick-P. Sekaly, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2003) 171 (8): 4311–4319.
https://doi.org/10.4049/jimmunol.171.8.4311
Published: 15 October 2003
View article titled, Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86
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Journal Articles

Cutting Edge: DNA Immunization with Minigenes of Carbohydrate Mimotopes Induce Functional Anti-Carbohydrate Antibody Response

Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi, Bin Wang, Ping Luo, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2000) 165 (2): 623–627.
https://doi.org/10.4049/jimmunol.165.2.623
Published: 15 July 2000
View article titled, Cutting Edge: DNA Immunization with Minigenes of Carbohydrate Mimotopes Induce Functional Anti-Carbohydrate Antibody Response
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Journal Articles

CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo

Michael G. Agadjanyan, Jong J. Kim, Neil Trivedi, Darren M. Wilson, Behjatolah Monzavi-Karbassi, Lake D. Morrison, Liesl K. Nottingham, Tzvete Dentchev, Anthony Tsai, Kesen Dang, Ara A. Chalian, Michael A. Maldonado, William V. Williams, David B. Weiner
Journal: The Journal of Immunology
J Immunol (1999) 162 (6): 3417–3427.
https://doi.org/10.4049/jimmunol.162.6.3417
Published: 15 March 1999
View article titled, CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo
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Journal Articles

IL-12 Gene as a DNA Vaccine Adjuvant in a Herpes Mouse Model: IL-12 Enhances Th1-Type CD4+ T Cell-Mediated Protective Immunity Against Herpes Simplex Virus-2 Challenge

Jeong-Im Sin, Jong J. Kim, Renee L. Arnold, Khushroo E. Shroff, Don McCallus, Cathy Pachuk, Sue P. McElhiney, Mary W. Wolf, Sylvia J. Pompa-de Bruin, Terry J. Higgins, Richard B. Ciccarelli, David B. Weiner
Journal: The Journal of Immunology
J Immunol (1999) 162 (5): 2912–2921.
https://doi.org/10.4049/jimmunol.162.5.2912
Published: 01 March 1999
View article titled, IL-12 Gene as a DNA Vaccine Adjuvant in a Herpes Mouse Model: IL-12 Enhances Th1-Type CD4<sup>+</sup> T Cell-Mediated Protective Immunity Against Herpes Simplex Virus-2 Challenge
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Journal Articles

Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells

Michael A. Chattergoon, Tara M. Robinson, Jean D. Boyer, David B. Weiner
Journal: The Journal of Immunology
J Immunol (1998) 160 (12): 5707–5718.
https://doi.org/10.4049/jimmunol.160.12.5707
Published: 15 June 1998
View article titled, Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells
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