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David V. Serreze
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Journal Articles

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy

Jeremy J. Racine, John F. Bachman, Ji-Gang Zhang, Adel Misherghi, Raheem Khadour, Sana Kaisar, Olivia Bedard, Catherine Jenkins, Annie Abbott, Elvira Forte, Peter Rainer, Nadia Rosenthal, Susanne Sattler, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2024) 212 (8): 1287–1306.
https://doi.org/10.4049/jimmunol.2300841
Published: 01 March 2024
View article titled, Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy
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Includes: Supplementary data
Journal Articles

HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice

Jeremy J. Racine, Adel Misherghi, Jennifer R. Dwyer, Richard Maser, Elvira Forte, Olivia Bedard, Susanne Sattler, Alberto Pugliese, Laurie Landry, Colleen Elso, Maki Nakayama, Stuart Mannering, Nadia Rosenthal, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2023) 211 (12): 1792–1805.
https://doi.org/10.4049/jimmunol.2300303
Published: 15 December 2023
View article titled, HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice
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Includes: Supplementary data
Journal Articles

Deletion of Vβ3 +CD4 +T-cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8 +T-cells

John P Driver, Cheng Ye, Sadie Clements, Weihong Gu, Aron Geurts, Clayton Mathews, David V Serreze, Yi-Guang Chen
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 170.05.
https://doi.org/10.4049/jimmunol.210.Supp.170.05
Published: 01 May 2023
View article titled, Deletion of Vβ3 <sup>+</sup>CD4 <sup>+</sup>T-cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8 <sup>+</sup>T-cells
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Journal Articles

Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes

Ashley E. Ciecko, Yu Wang, Stephanie Harleston, Amber Drewek, David V. Serreze, Aron M. Geurts, Chien-Wei Lin, Yi-Guang Chen
Journal: The Journal of Immunology
J Immunol (2023) 210 (7): 935–946.
https://doi.org/10.4049/jimmunol.2200712
Published: 10 February 2023
View article titled, Heterogeneity of Islet-Infiltrating IL-21<sup>+</sup> CD4 T Cells in a Mouse Model of Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells

Jennifer R. Dwyer, Jeremy J. Racine, Harold D. Chapman, Anna Quinlan, Maximiliano Presa, Grace A. Stafford, Ingo Schmitz, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2022) 209 (2): 227–237.
https://doi.org/10.4049/jimmunol.2100558
Published: 15 July 2022
View article titled, Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells
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Includes: Supplementary data
Journal Articles

T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue

Jeremy J. Racine, Harold D. Chapman, Rosalinda Doty, Brynn M. Cairns, Timothy J. Hines, Abigail L. D. Tadenev, Laura C. Anderson, Torrian Green, Meaghan E. Dyer, Janine M. Wotton, Zoë Bichler, Jacqueline K. White, Rachel Ettinger, Robert W. Burgess, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2020) 205 (8): 2026–2038.
https://doi.org/10.4049/jimmunol.2000114
Published: 15 October 2020
View article titled, T Cells from NOD-<em>PerIg</em> Mice Target Both Pancreatic and Neuronal Tissue
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Includes: Supplementary data
Journal Articles

CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice

Cheng Ye, Benjamin E. Low, Michael V. Wiles, Todd M. Brusko, David V. Serreze, John P. Driver
Journal: The Journal of Immunology
J Immunol (2020) 205 (7): 1763–1777.
https://doi.org/10.4049/jimmunol.2000148
Published: 01 October 2020
View article titled, CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice
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Includes: Supplementary data
Journal Articles

The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells

Bardees M. Foda, Ashley E. Ciecko, David V. Serreze, William M. Ridgway, Aron M. Geurts, Yi-Guang Chen
Journal: The Journal of Immunology
J Immunol (2020) 204 (11): 2887–2899.
https://doi.org/10.4049/jimmunol.1900485
Published: 01 June 2020
View article titled, The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137<sup>+</sup> FOXP3<sup>+</sup> Regulatory CD4 T Cells
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Includes: Supplementary data
Journal Articles

T-cells from NOD-PerIg mice transfer aggressive peripheral neuritis to NOD. scid recipients

Jeremy J Racine, Harold D Chapman, Rosalinda Doty, Brynn M Cairns, Timothy J Hines, Abigail L.D. Tadenev, Laura C Anderson, Torrian Green, Meaghan Dyer, Jacqui White, Rachel Ettinger, Robert W Burgess, David V Serreze
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 58.6.
https://doi.org/10.4049/jimmunol.204.Supp.58.6
Published: 01 May 2020
View article titled, T-cells from NOD-<em>PerIg</em> mice transfer aggressive peripheral neuritis to NOD. <em>scid</em> recipients
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Journal Articles

Nfkbid overexpression in NOD mice elicits complete type 1 diabetes resistance

Jennifer R Dwyer, Jeremy J Racine, Anna Quinlan, Maximiliano Presa, Harold D Chapman, David V Serreze
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 115.8.
https://doi.org/10.4049/jimmunol.202.Supp.115.8
Published: 01 May 2019
View article titled, <em>Nfkbid</em> overexpression in NOD mice elicits complete type 1 diabetes resistance
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Journal Articles

Unmasking a killer: discovery of a gene that controls the pathogenic activation of CD8 T cells in Type 1 diabetes

Cheng Ye, David V Serreze, Yi-Guang Chen, John P Driver
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 50.9.
https://doi.org/10.4049/jimmunol.202.Supp.50.9
Published: 01 May 2019
View article titled, Unmasking a killer: discovery of a gene that controls the pathogenic activation of CD8 T cells in Type 1 diabetes
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Journal Articles

A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice

Maximiliano Presa, Jeremy J. Racine, Jennifer R. Dwyer, Deanna J. Lamont, Jeremy J. Ratiu, Vishal Kumar Sarsani, Yi-Guang Chen, Aron Geurts, Ingo Schmitz, Timothy Stearns, Jennifer Allocco, Harold D. Chapman, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2018) 201 (7): 1907–1917.
https://doi.org/10.4049/jimmunol.1800465
Published: 01 October 2018
View article titled, A Hypermorphic <em>Nfkbid</em> Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8<sup>+</sup> T Cells in NOD Mice
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Includes: Supplementary data
Journal Articles

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression

Jennifer Schloss, Riyasat Ali, Jeremy J. Racine, Harold D. Chapman, David V. Serreze, Teresa P. DiLorenzo
Journal: The Journal of Immunology
J Immunol (2018) 200 (10): 3353–3363.
https://doi.org/10.4049/jimmunol.1701652
Published: 15 May 2018
View article titled, HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression
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Journal Articles

PLGA-microsphere delivery of insulin and IGRP epitopes as a therapy for type 1 diabetes

Jeremy J. Racine, Caroline M. Leeth, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 176.12.
https://doi.org/10.4049/jimmunol.200.Supp.176.12
Published: 01 May 2018
View article titled, PLGA-microsphere delivery of insulin and IGRP epitopes as a therapy for type 1 diabetes
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Journal Articles

Development of syngeneic NOD tumor models to study tumor immunity in autoimmune-prone mice.

Arabella Young, Vinh Nguyen, Sadaf Mehdizadeh, Kathleen C. F. Sheehan, David V. Serreze, Robert D. Schreiber, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 178.19.
https://doi.org/10.4049/jimmunol.200.Supp.178.19
Published: 01 May 2018
View article titled, Development of syngeneic NOD tumor models to study tumor immunity in autoimmune-prone mice.
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Journal Articles

Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy

Qiming Wang, Jeremy J. Racine, Jeremy J. Ratiu, Shu Wang, Rachel Ettinger, Clive Wasserfall, Mark A. Atkinson, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2017) 199 (11): 3757–3770.
https://doi.org/10.4049/jimmunol.1700822
Published: 01 December 2017
View article titled, Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy
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Includes: Supplementary data
Journal Articles

Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes

Jeremy J. Ratiu, Jeremy J. Racine, Muneer G. Hasham, Qiming Wang, Jane A. Branca, Harold D. Chapman, Jing Zhu, Nina Donghia, Vivek Philip, William H. Schott, Clive Wasserfall, Mark A. Atkinson, Kevin D. Mills, Caroline M. Leeth, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2017) 198 (11): 4255–4267.
https://doi.org/10.4049/jimmunol.1700024
Published: 01 June 2017
View article titled, Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes
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Includes: Supplementary data
Journal Articles

Autoimmune manifestations in aged mice arise from early-life immune dysregulation

Jodi Karnell, Tamer I. Mahmoud, Jingya Wang, Qiming Wang, Shu Wang, Brian Naiman, Philip Gross, Philip Z. Brohawn, Christopher Morehouse, Jordan Aoyama, Clive Wasserfall, Laura L Carter, Mark A. Atkinson, David V Serreze, Helen Braley-Mullen, Tomas Mikael Mustelin, Roland Kolbeck, Ronald Herbst, Rachel Ettinger
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 54.1.
https://doi.org/10.4049/jimmunol.198.Supp.54.1
Published: 01 May 2017
View article titled, Autoimmune manifestations in aged mice arise from early-life immune dysregulation
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Journal Articles

Combination B-lymphocyte Depletion Treatment with Anti-CD20 and BAFF Blockade is No Superior to BAFF Blockade Alone in The NOD Model of Type 1 Diabetes

Qiming Wang, David V Serreze
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 70.14.
https://doi.org/10.4049/jimmunol.196.Supp.70.14
Published: 01 May 2016
View article titled, Combination B-lymphocyte Depletion Treatment with Anti-CD20 and BAFF Blockade is No Superior to BAFF Blockade Alone in The NOD Model of Type 1 Diabetes
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The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice

Maximiliano Presa, Yi-Guang Chen, Alexandra E. Grier, Edward H. Leiter, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, David V. Serreze
Journal: The Journal of Immunology
J Immunol (2015) 195 (7): 3011–3019.
https://doi.org/10.4049/jimmunol.1402446
Published: 01 October 2015
View article titled, The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-<em>scid</em> Mice
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