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Dennis M. Klinman
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Journal Articles

Oral R848 Reduces Host Susceptibility to Enteric and Systemic L. monocytogenes Challenge

Neslihan Kayraklioglu, Begum Han Horuluoglu, Madhivanan Elango, Aslihan Turan, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 196.4.
DOI: https://doi.org/10.4049/jimmunol.202.Supp.196.4
Published: 01 May 2019
View article titled, Oral R848 Reduces Host Susceptibility to Enteric and Systemic L. monocytogenes Challenge
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PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus

Begum Han Horuluoglu, Defne Bayik, Neslihan Kayraklioglu, Emilie Goguet, Luz P Blanco, Mariana J Kaplan, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 182.21.
DOI: https://doi.org/10.4049/jimmunol.202.Supp.182.21
Published: 01 May 2019
View article titled, PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus
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Journal Articles

Intrapulmonary delivery of TLR agonists associated with systemic chemotherapy to treat metastatic cancer.

Emilie Goguet, Dennis M. Klinman, Debra Tross
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 58.4.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.58.4
Published: 01 May 2018
View article titled, Intrapulmonary delivery of TLR agonists associated with systemic chemotherapy to treat metastatic cancer.
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Modulation of TLR2/1 by PAM3CSK4 to induce generation of immunosuppressive macrophages as a therapeutic approach for SLE

Begum Han Horuluoglu, Defne Bayik, Emilie Goguet, Debra Tross, Luz P. Blanco, Mariana J. Kaplan, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 49.8.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.49.8
Published: 01 May 2018
View article titled, Modulation of TLR2/1 by PAM3CSK4 to induce generation of immunosuppressive macrophages as a therapeutic approach for SLE
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Journal Articles

Effects of TLR 7 and 8 agonists on human monocyte activation and differentiation

Neslihan Kayraklioglu, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 109.8.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.109.8
Published: 01 May 2018
View article titled, Effects of TLR 7 and 8 agonists on human monocyte activation and differentiation
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Journal Articles

Pro-inflammatory properties of orally delivered calcium-encapsulated CpG Oligodeoxynucleotides

Neslihan Kayraklioglu, Katherine H Parker, Julia Scheiermann, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 79.6.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.79.6
Published: 01 May 2017
View article titled, Pro-inflammatory properties of orally delivered calcium-encapsulated CpG Oligodeoxynucleotides
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Journal Articles

Intrapulmonary delivery of TLR agonists to treat metastatic cancer

Emilie Goguet, Debra Tross, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 120.16.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.120.16
Published: 01 May 2017
View article titled, Intrapulmonary delivery of TLR agonists to treat metastatic cancer
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Journal Articles

Identification of a conserved regulatory network underlying the differentiation of immunosuppressive human macrophage

Defne Bayik, Debra Tross, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 222.28.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.222.28
Published: 01 May 2017
View article titled, Identification of a conserved regulatory network underlying the differentiation of immunosuppressive human macrophage
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Journal Articles

Three distinct pneumotypes characterize the microbiome of the lung in BALB/cJ mice.

Julia Scheiermann, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 153.8.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.153.8
Published: 01 May 2017
View article titled, Three distinct pneumotypes characterize the microbiome of the lung in BALB/cJ mice.
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Journal Articles

Shedding New Light on the Process of “Licensing” for Pathogenicity by Th Lymphocytes

Cuiyan Tan, Wambui S. Wandu, R. Steven Lee, Samuel H. Hinshaw, Dennis M. Klinman, Eric Wawrousek, Igal Gery
Journal: The Journal of Immunology
J Immunol (2017) 198 (2): 681–690.
DOI: https://doi.org/10.4049/jimmunol.1502108
Published: 15 January 2017
View article titled, Shedding New Light on the Process of “Licensing” for Pathogenicity by Th Lymphocytes
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Includes: Supplementary data
Journal Articles

Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells

Jing Wang, Yuko Shirota, Defne Bayik, Hidekazu Shirota, Debra Tross, James L. Gulley, Lauren V. Wood, Jay A. Berzofsky, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2015) 194 (9): 4215–4221.
DOI: https://doi.org/10.4049/jimmunol.1402004
Published: 01 May 2015
View article titled, Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells
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Includes: Supplementary data
Journal Articles

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

John J. Kaminski, Stefan A. Schattgen, Te-Chen Tzeng, Christian Bode, Dennis M. Klinman, Katherine A. Fitzgerald
Journal: The Journal of Immunology
J Immunol (2013) 191 (7): 3876–3883.
DOI: https://doi.org/10.4049/jimmunol.1300530
Published: 01 October 2013
View article titled, Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
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Includes: Supplementary data
Journal Articles

β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

Poonam Tewary, Gonzalo de la Rosa, Neeraj Sharma, Luis G. Rodriguez, Sergey G. Tarasov, O. M. Zack Howard, Hidekazu Shirota, Folkert Steinhagen, Dennis M. Klinman, De Yang, Joost J. Oppenheim
Journal: The Journal of Immunology
J Immunol (2013) 191 (2): 865–874.
DOI: https://doi.org/10.4049/jimmunol.1201648
Published: 15 July 2013
View article titled, β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation
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Journal Articles

Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands

Guangpu Shi, Barbara P. Vistica, Lindsey F. Nugent, Cuiyan Tan, Eric F. Wawrousek, Dennis M. Klinman, Igal Gery
Journal: The Journal of Immunology
J Immunol (2013) 191 (1): 415–423.
DOI: https://doi.org/10.4049/jimmunol.1201732
Published: 01 July 2013
View article titled, Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands
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Journal Articles

Oligodeoxynucleotides Expressing Polyguanosine Motifs Promote Antitumor Activity through the Upregulation of IL-2

Nobuaki Kobayashi, Choongman Hong, Dennis M. Klinman, Hidekazu Shirota
Journal: The Journal of Immunology
J Immunol (2013) 190 (4): 1882–1889.
DOI: https://doi.org/10.4049/jimmunol.1201063
Published: 15 February 2013
View article titled, Oligodeoxynucleotides Expressing Polyguanosine Motifs Promote Antitumor Activity through the Upregulation of IL-2
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Includes: Supplementary data
Journal Articles

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Yuko Shirota, Hidekazu Shirota, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2012) 188 (4): 1592–1599.
DOI: https://doi.org/10.4049/jimmunol.1101304
Published: 15 February 2012
View article titled, Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
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Includes: Supplementary data
Journal Articles

CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice (135.5)

Takashi Sato, Takeshi Shimosato, Dennis M Klinman
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 135.5.
DOI: https://doi.org/10.4049/jimmunol.182.Supp.135.5
Published: 01 April 2009
View article titled, CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice (135.5)
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Journal Articles

Effect of CpG Oligonucleotides on Vaccine-Induced B Cell Memory

Debra Tross, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2008) 181 (8): 5785–5790.
DOI: https://doi.org/10.4049/jimmunol.181.8.5785
Published: 15 October 2008
View article titled, Effect of CpG Oligonucleotides on Vaccine-Induced B Cell Memory
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Journal Articles

Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation

Takashi Sato, Takeshi Shimosato, W. Gregory Alvord, Dennis M. Klinman
Journal: The Journal of Immunology
J Immunol (2008) 180 (11): 7648–7654.
DOI: https://doi.org/10.4049/jimmunol.180.11.7648
Published: 01 June 2008
View article titled, Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation
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Journal Articles

Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine

Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M. Klinman, Satoshi Uematsu, Ken J. Ishii, Shizuo Akira, Kenji Okuda
Journal: The Journal of Immunology
J Immunol (2007) 179 (2): 1147–1154.
DOI: https://doi.org/10.4049/jimmunol.179.2.1147
Published: 15 July 2007
View article titled, Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine
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