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Dorothy Hudig
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Journal Articles

A Case for idiopathic CD8 T cell lymphocytopenia as a medical condition

Alexander Sung, Dorothy Hudig, Judith Cruz-Amaya, Staci Dooley, John Hess
Journal: The Journal of Immunology
J Immunol (2024) 212 (1_Supplement): 0589_5176.
https://doi.org/10.4049/jimmunol.212.supp.0589.5176
Published: 01 May 2024
View article titled, A Case for idiopathic CD8 T cell lymphocytopenia as a medical condition
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NK-92-CD16A cell externalization of CD107a for detection of antigen-specific antibodies able to support ADCC: sensitive discrimination of antibody a-fucosylation

Judith B Cruz Amaya, Bruce Walcheck, Julie Smith-Gagen, Vincent Lombardi, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 154.12.
https://doi.org/10.4049/jimmunol.210.Supp.154.12
Published: 01 May 2023
View article titled, NK-92-CD16A cell externalization of CD107a for detection of antigen-specific antibodies able to support ADCC: sensitive discrimination of antibody a-fucosylation
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CD95/Fas-ligation and resting NK or IL-2 activated NK (LAK) attack limit NK-92 efficacy.

Lydia T Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Rebecca Merica, Julie Smith-Gagen, Vincent C Lombardi, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 62.03.
https://doi.org/10.4049/jimmunol.208.Supp.62.03
Published: 01 May 2022
View article titled, CD95/Fas-ligation and resting NK or IL-2 activated NK (LAK) attack limit NK-92 efficacy.
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Evaluation of the DNA topoisomerase inhibitor irinotecan (CPT-11) as an alternative to irradiation for pretreatment of NK-92s prior to adoptive cell immunotherapy.

Judith B Cruz Amaya, Lydia T Navarrete-Galvan, Vincent C Lombardi, Matthew Isom, Julie Smith-Gagen, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 54.20.
https://doi.org/10.4049/jimmunol.208.Supp.54.20
Published: 01 May 2022
View article titled, Evaluation of the DNA topoisomerase inhibitor irinotecan (CPT-11) as an alternative to irradiation for pretreatment of NK-92s prior to adoptive cell immunotherapy.
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NK-92 serial killers - characterization of potential limitations to cytotoxic capacity.

Lydia T Navarrete-Galvan, Michael Guglielmo, Alexander Sung, Julie Smith-Gagen, Vincent Lombardi, Rebecca Merica, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 57.09.
https://doi.org/10.4049/jimmunol.206.Supp.57.09
Published: 01 May 2021
View article titled, NK-92 serial killers - characterization of potential limitations to cytotoxic capacity.
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Two-color flow cytometric detection of serial cell-mediated cytotoxicity by natural killer (NK) lymphocytes

Lydia T Navarrete-Galvan, Michael Guglielmo, Julie Smith-Gagen, Rebecca Merica, Vincent C Lombardi, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 88.5.
https://doi.org/10.4049/jimmunol.204.Supp.88.5
Published: 01 May 2020
View article titled, Two-color flow cytometric detection of serial cell-mediated cytotoxicity by natural killer (NK) lymphocytes
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Evidence for serial antibody-dependent cell-mediated cytotoxicity (ADCC) by primary unstimulated human natural killer (NK) lymphocytes

Alexander P Sung, Lydia T Navarrete-Galvan, Michael Guglielmo, Julie Smith-Gagen, Douglas D Redelman, Rebecca Merica, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 148.44.
https://doi.org/10.4049/jimmunol.204.Supp.148.44
Published: 01 May 2020
View article titled, Evidence for serial antibody-dependent cell-mediated cytotoxicity (ADCC) by primary unstimulated human natural killer (NK) lymphocytes
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Monocytes of Chronic Fatigue Syndrome Patients, their Family Members without CFS, and Unrelated Healthy Donors: Searching for Differences

Dorothy Hudig, Keli Tokunaga, Alexander P Sung, Michael J Guglielmo, Julie Smith-Gagen, Rebecca Merica, Doug Redelman
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 182.50.
https://doi.org/10.4049/jimmunol.202.Supp.182.50
Published: 01 May 2019
View article titled, Monocytes of Chronic Fatigue Syndrome Patients, their Family Members without CFS, and Unrelated Healthy Donors: Searching for Differences
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Journal Articles

Low NK Cell ADCC as a Risk Factor in Chronic Fatigue Syndrome (CFS): Familial Risk for CFS or Differences between Human Populations?

Dorothy Hudig, Jennifer Tang, Alexander P. Sung, Michael J. Guglielmo, Julie Smith-Gagen, Lucinda Bateman, Douglas D. Redelman
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 49.15.
https://doi.org/10.4049/jimmunol.200.Supp.49.15
Published: 01 May 2018
View article titled, Low NK Cell ADCC as a Risk Factor in Chronic Fatigue Syndrome (CFS): Familial Risk for CFS or Differences between Human Populations?
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Correlation of NK Cell Phenotypic Properties with Individual Differences in Human Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Dorothy Hudig, Jennifer J-J Tang, Alexander P. Sung, Micheal Guglielmo, Julie Smith-Gagen, Stephen K. Anderson, Lucinda Bateman, Isabel Barao, Doug D. Redelman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 67.16.
https://doi.org/10.4049/jimmunol.198.Supp.67.16
Published: 01 May 2017
View article titled, Correlation of NK Cell Phenotypic Properties with Individual Differences in Human Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
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Quantitative assay of human antibody-dependent cell-mediated cytotoxicity (ADCC) using peripheral blood mononuclear cells (PBMCs)

Alexander P Sung, Jia Jie Tang, Michael J. Guglielmo, Douglas D Redelman, Isabel Barao Silvestre, Julie Smith Gagen, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 195.10.
https://doi.org/10.4049/jimmunol.196.Supp.195.10
Published: 01 May 2016
View article titled, Quantitative assay of human antibody-dependent cell-mediated cytotoxicity (ADCC) using peripheral blood mononuclear cells (PBMCs)
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Assessment of the Fc receptor CD16A of NK cells of CFS patients for potential to mediate ADCC activity (HUM1P.303)

Isabel Silvestre, Daniel Peterson, Douglas Redelman, Stephen Anderson, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2015) 194 (1_Supplement): 52.28.
https://doi.org/10.4049/jimmunol.194.Supp.52.28
Published: 01 May 2015
View article titled, Assessment of the Fc receptor CD16A of NK cells of CFS patients for potential to mediate ADCC activity (HUM1P.303)
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Journal Articles

High perforin levels in freshly isolated human CD56neg NK cells (P4345)

Isabel Barao, Doug Redelman, Kenneth Hunter, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2013) 190 (1_Supplement): 183.8.
https://doi.org/10.4049/jimmunol.190.Supp.183.8
Published: 01 May 2013
View article titled, High perforin levels in freshly isolated human CD56neg NK cells (P4345)
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Elevated numbers and frequencies of CD56- CD3- NK cells with high perforin occur in healthy donors (160.14)

Dorothy Hudig, Isabel Barao, Kenneth Hunter, W. Diamond, Doug Redelman
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 160.14.
https://doi.org/10.4049/jimmunol.186.Supp.160.14
Published: 01 April 2011
View article titled, Elevated numbers and frequencies of CD56- CD3- NK cells with high perforin occur in healthy donors (160.14)
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Cytotoxic mechanisms of IL-4 polarized CTLs (101.28)

Dorothy Hudig, Christopher McKinney, Bryce Alves, David Tamang, Doug Redelman, Cherie Singer, Viki Elliott
Journal: The Journal of Immunology
J Immunol (2010) 184 (1_Supplement): 101.28.
https://doi.org/10.4049/jimmunol.184.Supp.101.28
Published: 01 April 2010
View article titled, Cytotoxic mechanisms of IL-4 polarized CTLs (101.28)
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Characterization of the therapeutic increases in natural killer (NK) activity of xenotropic murine leukemia virus-related virus (XMRV)-positive chronic fatigue syndrome (CFS) patients effected by poly (I): poly (C12U) (Ampligen) (89.49)

Isabel Silvestre, Maria Marshall, Kathryn Hagen, Max Pfost, David Strayer, Daniel Peterson, Dorothy Hudig, Judy Mikovits
Journal: The Journal of Immunology
J Immunol (2010) 184 (1_Supplement): 89.49.
https://doi.org/10.4049/jimmunol.184.Supp.89.49
Published: 01 April 2010
View article titled, Characterization of the therapeutic increases in natural killer (NK) activity of xenotropic murine leukemia virus-related virus (XMRV)-positive chronic fatigue syndrome (CFS) patients effected by poly (I): poly (C12U) (Ampligen) (89.49)
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Journal Articles

Triglyceride lipids can enhance the cytotoxicity of induced cytotoxic T lymphocytes (CTLs) (83.8)

Dorothy Hudig, Bryce N Alves, Kristen Marshall, David L Tamang, Jeffrey Leong, Doug Redelman, Viki Elliott, Mark E Lowe
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 83.8.
https://doi.org/10.4049/jimmunol.182.Supp.83.8
Published: 01 April 2009
View article titled, Triglyceride lipids can enhance the cytotoxicity of induced cytotoxic T lymphocytes (CTLs) (83.8)
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Sensitization of Tumor Cells to NK Cell-Mediated Killing by Proteasome Inhibition

William H.D. Hallett, Erik Ames, Milad Motarjemi, Isabel Barao, Anil Shanker, David L. Tamang, Thomas J. Sayers, Dorothy Hudig, William J. Murphy
Journal: The Journal of Immunology
J Immunol (2008) 180 (1): 163–170.
https://doi.org/10.4049/jimmunol.180.1.163
Published: 01 January 2008
View article titled, Sensitization of Tumor Cells to NK Cell-Mediated Killing by Proteasome Inhibition
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IL-15-Mediated Induction of LFA-1 Is a Late Step Required for Cytotoxic Differentiation of Human NK Cells from CD34+Lin− Bone Marrow Cells

Isabel Barao, Dorothy Hudig, Joao L. Ascensao
Journal: The Journal of Immunology
J Immunol (2003) 171 (2): 683–690.
https://doi.org/10.4049/jimmunol.171.2.683
Published: 15 July 2003
View article titled, IL-15-Mediated Induction of LFA-1 Is a Late Step Required for Cytotoxic Differentiation of Human NK Cells from CD34<sup>+</sup>Lin<sup>−</sup> Bone Marrow Cells
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Perforin Lytic Activity Is Controlled by Calreticulin

Stephanie A. Fraser, Reza Karimi, Marek Michalak, Dorothy Hudig
Journal: The Journal of Immunology
J Immunol (2000) 164 (8): 4150–4155.
https://doi.org/10.4049/jimmunol.164.8.4150
Published: 15 April 2000
View article titled, Perforin Lytic Activity Is Controlled by Calreticulin
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