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Eicke Latz
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Journal Articles

Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies

Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T. Heneka
Journal: The Journal of Immunology
J Immunol (2021) 207 (8): 2143–2154.
DOI: https://doi.org/10.4049/jimmunol.2100035
Published: 15 October 2021
View article titled, Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies
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Includes: Supplementary data
Journal Articles

Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice

Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, Zhichao Fan, Lai Wen, Yunmin Jung, Payel Roy, Yukiko Myamoto, Hiroaki Matsunami, Lars Eckmann, Eicke Latz, Zeneng Wang, Stanley L Hazen, Klaus Ley
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 68.22.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.68.22
Published: 01 May 2020
View article titled, Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice
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Charcot–Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages

Juan Francisco Rodríguez-Alcázar, Marco Antonio Ataide, Gudrun Engels, Christine Schmitt-Mabmunyo, Natalio Garbi, Wolfgang Kastenmüller, Eicke Latz, Bernardo S. Franklin
Journal: The Journal of Immunology
J Immunol (2019) 202 (2): 550–558.
DOI: https://doi.org/10.4049/jimmunol.1800107
Published: 15 January 2019
View article titled, Charcot–Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages
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Includes: Multimedia, Supplementary data
Journal Articles

Cyclodextrin Reduces Cholesterol Crystal–Induced Inflammation by Modulating Complement Activation

Siril S. Bakke, Marie H. Aune, Nathalie Niyonzima, Katrine Pilely, Liv Ryan, Mona Skjelland, Peter Garred, Pål Aukrust, Bente Halvorsen, Eicke Latz, Jan K. Damås, Tom E. Mollnes, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2017) 199 (8): 2910–2920.
DOI: https://doi.org/10.4049/jimmunol.1700302
Published: 15 October 2017
View article titled, Cyclodextrin Reduces Cholesterol Crystal–Induced Inflammation by Modulating Complement Activation
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Includes: Supplementary data
Journal Articles

RAGE Enhances TLR Responses through Binding and Internalization of RNA

Damien Bertheloot, Allison L. Naumovski, Pia Langhoff, Gabor L. Horvath, Tengchuan Jin, Tsan Sam Xiao, Natalio Garbi, Sudhir Agrawal, Roland Kolbeck, Eicke Latz
Journal: The Journal of Immunology
J Immunol (2016) 197 (10): 4118–4126.
DOI: https://doi.org/10.4049/jimmunol.1502169
Published: 15 November 2016
View article titled, RAGE Enhances TLR Responses through Binding and Internalization of RNA
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Includes: Supplementary data
Journal Articles

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Michael J. Primiano, Bruce A. Lefker, Michael R. Bowman, Andrea G. Bree, Cedric Hubeau, Paul D. Bonin, Matthew Mangan, Ken Dower, Brian G. Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth, J. Perry Hall
Journal: The Journal of Immunology
J Immunol (2016) 197 (6): 2421–2433.
DOI: https://doi.org/10.4049/jimmunol.1600035
Published: 15 September 2016
View article titled, Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
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Includes: Supplementary data
Journal Articles

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus

Lukas Bossaller, Anette Christ, Karin Pelka, Kerstin Nündel, Ping-I Chiang, Catherine Pang, Neha Mishra, Patricia Busto, Ramon G. Bonegio, Reinhold Ernst Schmidt, Eicke Latz, Ann Marshak-Rothstein
Journal: The Journal of Immunology
J Immunol (2016) 197 (4): 1044–1053.
DOI: https://doi.org/10.4049/jimmunol.1501943
Published: 15 August 2016
View article titled, TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus
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Includes: Supplementary data
Journal Articles

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J Vayttaden, Bin Lin, Thomas S Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain Fraser
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 203.22.
DOI: https://doi.org/10.4049/jimmunol.196.Supp.203.22
Published: 01 May 2016
View article titled, Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
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Journal Articles

ATF3 Is a Key Regulator of Macrophage IFN Responses

Larisa I. Labzin, Susanne V. Schmidt, Seth L. Masters, Marc Beyer, Wolfgang Krebs, Kathrin Klee, Rainer Stahl, Dieter Lütjohann, Joachim L. Schultze, Eicke Latz, Dominic De Nardo
Journal: The Journal of Immunology
J Immunol (2015) 195 (9): 4446–4455.
DOI: https://doi.org/10.4049/jimmunol.1500204
Published: 01 November 2015
View article titled, ATF3 Is a Key Regulator of Macrophage IFN Responses
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Includes: Supplementary data
Journal Articles

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes

Tatjana Eigenbrod, Karin Pelka, Eicke Latz, Bernd Kreikemeyer, Alexander H. Dalpke
Journal: The Journal of Immunology
J Immunol (2015) 195 (3): 1092–1099.
DOI: https://doi.org/10.4049/jimmunol.1403173
Published: 01 August 2015
View article titled, TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes
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Includes: Supplementary data
Journal Articles

Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal–Induced Inflammatory Responses by Reducing Complement Activation

Nathalie Niyonzima, Eivind O. Samstad, Marie H. Aune, Liv Ryan, Siril S. Bakke, Anne Mari Rokstad, Samuel D. Wright, Jan K. Damås, Tom E. Mollnes, Eicke Latz, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2015) 195 (1): 257–264.
DOI: https://doi.org/10.4049/jimmunol.1403044
Published: 01 July 2015
View article titled, Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal–Induced Inflammatory Responses by Reducing Complement Activation
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Journal Articles

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Selina K. Fassl, Judith Austermann, Olympia Papantonopoulou, Mona Riemenschneider, Jia Xue, Damien Bertheloot, Nicole Freise, Christoph Spiekermann, Anika Witten, Dorothee Viemann, Susanne Kirschnek, Monika Stoll, Eicke Latz, Joachim L. Schultze, Johannes Roth, Thomas Vogl
Journal: The Journal of Immunology
J Immunol (2015) 194 (2): 575–583.
DOI: https://doi.org/10.4049/jimmunol.1401085
Published: 15 January 2015
View article titled, Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8
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Includes: Supplementary data
Journal Articles

Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms

Karin Pelka, Kshiti Phulphagar, Jana Zimmermann, Rainer Stahl, Jonathan L. Schmid-Burgk, Tobias Schmidt, Jan-Hendrik Spille, Larisa I. Labzin, Sudhir Agrawal, Ekambar R. Kandimalla, Jean-Laurent Casanova, Veit Hornung, Ann Marshak-Rothstein, Stefan Höning, Eicke Latz
Journal: The Journal of Immunology
J Immunol (2014) 193 (7): 3257–3261.
DOI: https://doi.org/10.4049/jimmunol.1301886
Published: 01 October 2014
View article titled, Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms
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Includes: Supplementary data
Journal Articles

LC3-associated phagocytosis mediates IFN-alpha secretion in response to DNA-immune complexes. (BA3P.207)

Payal Mehta, Jill Henault, Jennifer Martinez, Jeffery Riggs, Jane Tian, Lorraine Clarke, Miwa Sasai, Eicke Latz, Melanie Brinkmann, Akiko Iwasaki, Anthony Coyle, Roland Kolbeck, Douglas Green, Miguel Sanjuan
Journal: The Journal of Immunology
J Immunol (2014) 192 (1_Supplement): 44.13.
DOI: https://doi.org/10.4049/jimmunol.192.Supp.44.13
Published: 01 May 2014
View article titled, LC3-associated phagocytosis mediates IFN-alpha secretion in response to DNA-immune complexes. (BA3P.207)
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Journal Articles

Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant

Nicholas S. Wilson, Peter Duewell, Becky Yang, Yun Li, Scot Marsters, Sandra Koernig, Eicke Latz, Eugene Maraskovsky, Adriana Baz Morelli, Max Schnurr, Avi Ashkenazi
Journal: The Journal of Immunology
J Immunol (2014) 192 (7): 3259–3268.
DOI: https://doi.org/10.4049/jimmunol.1302011
Published: 01 April 2014
View article titled, Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant
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Includes: Supplementary data
Journal Articles

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

Eivind O. Samstad, Nathalie Niyonzima, Stig Nymo, Marie H. Aune, Liv Ryan, Siril S. Bakke, Knut T. Lappegård, Ole-Lars Brekke, John D. Lambris, Jan K. Damås, Eicke Latz, Tom E. Mollnes, Terje Espevik
Journal: The Journal of Immunology
J Immunol (2014) 192 (6): 2837–2845.
DOI: https://doi.org/10.4049/jimmunol.1302484
Published: 15 March 2014
View article titled, Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
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Includes: Supplementary data
Journal Articles

Overexpression of Membrane-Bound Fas Ligand (CD95L) Exacerbates Autoimmune Disease and Renal Pathology in Pristane-Induced Lupus

Lukas Bossaller, Vijay A. K. Rathinam, Ramon Bonegio, Ping-I Chiang, Patricia Busto, Adam R. Wespiser, Daniel R. Caffrey, Quan-Zhen Li, Chandra Mohan, Katherine A. Fitzgerald, Eicke Latz, Ann Marshak-Rothstein
Journal: The Journal of Immunology
J Immunol (2013) 191 (5): 2104–2114.
DOI: https://doi.org/10.4049/jimmunol.1300341
Published: 01 September 2013
View article titled, Overexpression of Membrane-Bound Fas Ligand (CD95L) Exacerbates Autoimmune Disease and Renal Pathology in Pristane-Induced Lupus
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Includes: Supplementary data
Journal Articles

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

Lukas Bossaller, Ping-I Chiang, Christian Schmidt-Lauber, Sandhya Ganesan, William J. Kaiser, Vijay A. K. Rathinam, Edward S. Mocarski, Deepa Subramanian, Douglas R. Green, Neal Silverman, Katherine A. Fitzgerald, Ann Marshak-Rothstein, Eicke Latz
Journal: The Journal of Immunology
J Immunol (2012) 189 (12): 5508–5512.
DOI: https://doi.org/10.4049/jimmunol.1202121
Published: 15 December 2012
View article titled, Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
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Includes: Supplementary data
Journal Articles

Membrane-bound Fas ligand accelerates autoimmune disease in an induced murine model of systemic lupus erythematosus (123.3)

Lukas Bossaller, Vijay Rathinam, Christian Schmidt-Lauber, Krishna Moody, Ramon Bonegio, Katherine Fitzgerald, Eicke Latz, Ann Marshak-Rothstein
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 123.3.
DOI: https://doi.org/10.4049/jimmunol.188.Supp.123.3
Published: 01 May 2012
View article titled, Membrane-bound Fas ligand accelerates autoimmune disease in an induced murine model of systemic lupus erythematosus (123.3)
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Molecular mechanisms of Innate DNA recognition by the AIM2 and IFI16 inflammasomes (68.4)

Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay Rathinam, Veit Hornung, Ricky Johnstone, Eicke Latz, Andrew Bowie, Katherine Fitzgerald, T. Xiao
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 68.4.
DOI: https://doi.org/10.4049/jimmunol.188.Supp.68.4
Published: 01 May 2012
View article titled, Molecular mechanisms of Innate DNA recognition by the AIM2 and IFI16 inflammasomes (68.4)
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