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Frederick W. Alt
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Journal Articles

Orientation Regulation of Class-switch Recombination in Human B Cells

Likun Du, Valentyn Oksenych, Hui Wan, Xiaofei Ye, Junchao Dong, Adam Yongxin Ye, Hassan Abolhassani, Stelios Vlachiotis, Xuefei Zhang, Kathrin de la Rosa, Lennart Hammarström, Mirjam van der Burg, Frederick W. Alt, Qiang Pan-Hammarström
Journal: The Journal of Immunology
J Immunol ji2300842.
https://doi.org/10.4049/jimmunol.2300842
Published: 09 September 2024
View article titled, Orientation Regulation of Class-switch Recombination in Human B Cells
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Includes: Supplementary data
Journal Articles

Immunogenicity of a germline-targeting nanoparticle in knock-in mice expressing human B cell receptors of the HIV gp41 neutralizing antibody, DH511

Derek Wilson Cain, Ming Tian, Torben Schiffner, Kimmo Rantalainen, Kevin O. Saunders, Kevin Wiehe, Brian Watts, Andrew Ward, Gilad Ofek, Frederick W Alt, Barton F Haynes, William R Schief, S. Munir Alam
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 64.22.
https://doi.org/10.4049/jimmunol.208.Supp.64.22
Published: 01 May 2022
View article titled, Immunogenicity of a germline-targeting nanoparticle in knock-in mice expressing human B cell receptors of the HIV gp41 neutralizing antibody, DH511
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Journal Articles

Physiological V(D)J Recombination is Mediated by RAG Scanning of Loop-extruded Chromatin

Yu Zhang, Xuefei Zhang, Zhuoyi Liang, Zhaoqing Ba, Eddie Dring, Jeffrey Zurita, Aviva Presser Aiden, Erez Lieberman Aiden, Frederick W. Alt
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 123.18.
https://doi.org/10.4049/jimmunol.202.Supp.123.18
Published: 01 May 2019
View article titled, Physiological V(D)J Recombination is Mediated by RAG Scanning of Loop-extruded Chromatin
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Journal Articles

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Yoichi Shinkai, Shigeo Koyasu, Kei-ichi Nakayama, Kenneth M. Murphy, Dennis Y. Loh, Ellis L. Reinherz, Frederick W. Alt
Journal: The Journal of Immunology
J Immunol (2019) 202 (5): 1317–1320.
Published: 01 March 2019
View article titled, Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. <em>Science</em>. 1993. 259: 822-825
Open the PDF for Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. <em>Science</em>. 1993. 259: 822-825 in another window
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Journal Articles

An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments

Liang Chen, Lijuan Zhao, Frederick W. Alt, Michael S. Krangel
Journal: The Journal of Immunology
J Immunol (2016) 197 (8): 3188–3197.
https://doi.org/10.4049/jimmunol.1601124
Published: 15 October 2016
View article titled, An Ectopic CTCF Binding Element Inhibits <em>Tcrd</em> Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments
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Includes: Supplementary data
Journal Articles

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179–181

Ilan Bank, Ronald A. DePinho, Michael B. Brenner, Judy Cassimeris, Frederick W. Alt, Leonard Chess
Journal: The Journal of Immunology
J Immunol (2016) 196 (9): 3514–3516.
Published: 01 May 2016
View article titled, Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. <em>Nature</em>. 1986. 322: 179–181
Open the PDF for Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. <em>Nature</em>. 1986. 322: 179–181 in another window
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Journal Articles

Pillars Article: Developmentally Controlled and Tissue-Specific Expression of Unrearranged VH Gene Segments. Cell. 1985. 40: 271–281

George D. Yancopoulos, Frederick W. Alt
Journal: The Journal of Immunology
J Immunol (2012) 188 (1): 10–20.
Published: 01 January 2012
View article titled, Pillars Article: Developmentally Controlled and Tissue-Specific Expression of Unrearranged V<sub>H</sub> Gene Segments. <em>Cell</em>. 1985. 40: 271–281
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Journal Articles

Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining

Jennifer Eccleston, Catherine Yan, Karen Yuan, Frederick W. Alt, Erik Selsing
Journal: The Journal of Immunology
J Immunol (2011) 186 (4): 2336–2343.
https://doi.org/10.4049/jimmunol.1003104
Published: 15 February 2011
View article titled, Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining
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Includes: Supplementary data
Journal Articles

Assembled DJβ Complexes Influence TCRβ Chain Selection and Peripheral Vβ Repertoire

Andrea C. Carpenter, Katherine S. Yang-Iott, Linda H. Chao, Beth Nuskey, Scott Whitlow, Frederick W. Alt, Craig H. Bassing
Journal: The Journal of Immunology
J Immunol (2009) 182 (9): 5586–5595.
https://doi.org/10.4049/jimmunol.0803270
Published: 01 May 2009
View article titled, Assembled DJβ Complexes Influence TCRβ Chain Selection and Peripheral Vβ Repertoire
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Journal Articles

Productive Coupling of Accessible Vβ14 Segments and DJβ Complexes Determines the Frequency of Vβ14 Rearrangement

Sheila Ranganath, Andrea C. Carpenter, Megan Gleason, Albert C. Shaw, Craig H. Bassing, Frederick W. Alt
Journal: The Journal of Immunology
J Immunol (2008) 180 (4): 2339–2346.
https://doi.org/10.4049/jimmunol.180.4.2339
Published: 15 February 2008
View article titled, Productive Coupling of Accessible Vβ14 Segments and DJβ Complexes Determines the Frequency of Vβ14 Rearrangement
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Journal Articles

A Single DH Gene Segment Creates Its Own Unique CDR-H3 Repertoire and Is Sufficient for B cell Development and Immune Function

Robert L. Schelonka, Ivaylo I. Ivanov, David H. Jung, Gregory C. Ippolito, Lars Nitschke, Yingxin Zhuang, G. Larry Gartland, Jukka Pelkonen, Frederick W. Alt, Klaus Rajewsky, Harry W. Schroeder, Jr
Journal: The Journal of Immunology
J Immunol (2005) 175 (10): 6624–6632.
https://doi.org/10.4049/jimmunol.175.10.6624
Published: 15 November 2005
View article titled, A Single D<sub>H</sub> Gene Segment Creates Its Own Unique CDR-H3 Repertoire and Is Sufficient for B cell Development and Immune Function
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Includes: Supplementary data