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Georg Schett
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Journal Articles

Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis

Merlijn H. Kaaij, Jasper Rip, Kim C. M. Jeucken, Yik Y. Kan, Charlotte C. N. van Rooijen, Job Saris, Desiree Pots, Silke Frey, Joep Grootjans, Georg Schett, Leonie M. van Duivenvoorde, Martijn A. Nolte, Rudi W. Hendriks, Odilia B. J. Corneth, Jan Piet van Hamburg, Dominique L. P. Baeten, Sander W. Tas
Journal: The Journal of Immunology
J Immunol (2021) 207 (9): 2337–2346.
https://doi.org/10.4049/jimmunol.2100512
Published: 01 November 2021
View articletitled, Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis
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Includes: Supplementary data
Journal Articles

Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis

Alina Soare, Stefanie Weber, Lisa Maul, Simon Rauber, Ana Maria Gheorghiu, Markus Luber, Ismail Houssni, Arnd Kleyer, Gero von Pickardt, Manuel Gado, David Simon, Jürgen Rech, Georg Schett, Jörg H. W. Distler, Andreas Ramming
Journal: The Journal of Immunology
J Immunol (2018) 200 (4): 1249–1254.
https://doi.org/10.4049/jimmunol.1700596
Published: 15 February 2018
View articletitled, Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis
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Includes: Supplementary data
Journal Articles

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

Tobias Rothe, Natacha Ipseiz, Maria Faas, Stefanie Lang, Francesc Perez-Branguli, Daniel Metzger, Hiroshi Ichinose, Beate Winner, Georg Schett, Gerhard Krönke
Journal: The Journal of Immunology
J Immunol (2017) 198 (10): 3878–3885.
https://doi.org/10.4049/jimmunol.1600638
Published: 15 May 2017
View articletitled, The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation
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Includes: Supplementary data
Journal Articles

The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages

Nicole Hannemann, Jutta Jordan, Sushmita Paul, Stephen Reid, Hanns-Wolf Baenkler, Sophia Sonnewald, Tobias Bäuerle, Julio Vera, Georg Schett, Aline Bozec
Journal: The Journal of Immunology
J Immunol (2017) 198 (9): 3605–3614.
https://doi.org/10.4049/jimmunol.1601330
Published: 01 May 2017
View articletitled, The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages
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Includes: Supplementary data
Journal Articles

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption

Nikolaus Binder, Christine Miller, Masaki Yoshida, Kazuki Inoue, Shinichi Nakano, Xiaoyu Hu, Lionel B. Ivashkiv, Georg Schett, Alessandra Pernis, Steven R. Goldring, F. Patrick Ross, Baohong Zhao
Journal: The Journal of Immunology
J Immunol (2017) 198 (9): 3436–3447.
https://doi.org/10.4049/jimmunol.1601716
Published: 01 May 2017
View articletitled, Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption
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Includes: Supplementary data
Journal Articles

Neurodegeneration Enhances the Development of Arthritis

Stefanie C. Lang, Ulrike Harre, Pavitra Purohit, Katharina Dietel, Deborah Kienhöfer, Jonas Hahn, Wolfgang Baum, Martin Herrmann, Georg Schett, Dirk Mielenz
Journal: The Journal of Immunology
J Immunol (2017) 198 (6): 2394–2402.
https://doi.org/10.4049/jimmunol.1601472
Published: 15 March 2017
View articletitled, Neurodegeneration Enhances the Development of Arthritis
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Includes: Supplementary data
Journal Articles

Reduced Fluorescence versus Forward Scatter Time-of-Flight and Increased Peak versus Integral Fluorescence Ratios Indicate Receptor Clustering in Flow Cytometry

Barbara G. Fürnrohr, Merle Stein, Benjamin Rhodes, Prabhjoat S. Chana, Georg Schett, Timothy J. Vyse, Martin Herrmann, Dirk Mielenz
Journal: The Journal of Immunology
J Immunol (2015) 195 (1): 377–385.
https://doi.org/10.4049/jimmunol.1401889
Published: 01 July 2015
View articletitled, Reduced Fluorescence versus Forward Scatter Time-of-Flight and Increased Peak versus Integral Fluorescence Ratios Indicate Receptor Clustering in Flow Cytometry
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Includes: Supplementary data
Journal Articles

Inhibition of Bone Remodeling in Young Mice by Bisphosphonate Displaces the Plasma Cell Niche into the Spleen

Stefan Teufel, Bettina Grötsch, Julia Luther, Anja Derer, Thorsten Schinke, Michael Amling, Georg Schett, Dirk Mielenz, Jean-Pierre David
Journal: The Journal of Immunology
J Immunol (2014) 193 (1): 223–233.
https://doi.org/10.4049/jimmunol.1302713
Published: 01 July 2014
View articletitled, Inhibition of Bone Remodeling in Young Mice by Bisphosphonate Displaces the Plasma Cell Niche into the Spleen
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Includes: Supplementary data
Journal Articles

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

Natacha Ipseiz, Stefan Uderhardt, Carina Scholtysek, Martin Steffen, Gernot Schabbauer, Aline Bozec, Georg Schett, Gerhard Krönke
Journal: The Journal of Immunology
J Immunol (2014) 192 (10): 4852–4858.
https://doi.org/10.4049/jimmunol.1303377
Published: 15 May 2014
View articletitled, The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
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Includes: Supplementary data
Journal Articles

The AP-1 transcription factor Fra-1 is a negative regulator of B2B cell proliferation and of immunoglobulin class switch (111.49)

Bettina Groetsch, Christiane Lang, Kirsten Neubert, Sebastian Brachs, Christine Zech, Anja Derer, Julia Luther, David Voehringer, Erwin Wagner, Georg Schett, Dirk Mielenz, Jean-Pierre David
Journal: The Journal of Immunology
J Immunol (2012) 188 (1_Supplement): 111.49.
https://doi.org/10.4049/jimmunol.188.Supp.111.49
Published: 01 May 2012
View articletitled, The AP-1 transcription factor Fra-1 is a negative regulator of B2B cell proliferation and of immunoglobulin class switch (111.49)
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Journal Articles

IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-α–Mediated Bone Loss

Mario M. Zaiss, Mariola Kurowska-Stolarska, Christina Böhm, Regina Gary, Carina Scholtysek, Bartosz Stolarski, James Reilly, Shauna Kerr, Neal L. Millar, Thomas Kamradt, Iain B. McInnes, Padraic G. Fallon, Jean-Pierre David, Foo Y. Liew, Georg Schett
Journal: The Journal of Immunology
J Immunol (2011) 186 (11): 6097–6105.
https://doi.org/10.4049/jimmunol.1003487
Published: 01 June 2011
View articletitled, IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-α–Mediated Bone Loss
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Includes: Supplementary data
Journal Articles

Response to Comment on “Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis”

Georg Schett
Journal: The Journal of Immunology
J Immunol (2011) 186 (1): 3–4.
https://doi.org/10.4049/jimmunol.1090116
Published: 01 January 2011
View articletitled, Response to Comment on “Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis”
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Journal Articles

The Early Marginal Zone B Cell-Initiated T-Independent Type 2 Response Resists the Proteasome Inhibitor Bortezomib

Veronika R. Lang, Dirk Mielenz, Kirsten Neubert, Christina Böhm, Georg Schett, Hans-Martin Jäck, Reinhard E. Voll, Silke Meister
Journal: The Journal of Immunology
J Immunol (2010) 185 (9): 5637–5647.
https://doi.org/10.4049/jimmunol.1001040
Published: 01 November 2010
View articletitled, The Early Marginal Zone B Cell-Initiated T-Independent Type 2 Response Resists the Proteasome Inhibitor Bortezomib
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Journal Articles

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

Mario M. Zaiss, Benjamin Frey, Andreas Hess, Jochen Zwerina, Julia Luther, Falk Nimmerjahn, Klaus Engelke, George Kollias, Thomas Hünig, Georg Schett, Jean-Pierre David
Journal: The Journal of Immunology
J Immunol (2010) 184 (12): 7238–7246.
https://doi.org/10.4049/jimmunol.0903841
Published: 15 June 2010
View articletitled, Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis
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Journal Articles

The α-Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

Christina Böhm, Silvia Hayer, Anita Kilian, Mario M. Zaiss, Susann Finger, Andreas Hess, Klaus Engelke, George Kollias, Gerhard Krönke, Jochen Zwerina, Georg Schett, Jean-Pierre David
Journal: The Journal of Immunology
J Immunol (2009) 183 (9): 5938–5947.
https://doi.org/10.4049/jimmunol.0901026
Published: 01 November 2009
View articletitled, The α-Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss
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Journal Articles

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

Gerhard Krönke, Julia Katzenbeisser, Stefan Uderhardt, Mario M. Zaiss, Carina Scholtysek, Gernot Schabbauer, Alexander Zarbock, Marije I. Koenders, Roland Axmann, Jochen Zwerina, Hans W. Baenckler, Wim van den Berg, Reinhard E. Voll, Hartmut Kühn, Leo A. B. Joosten, Georg Schett
Journal: The Journal of Immunology
J Immunol (2009) 183 (5): 3383–3389.
https://doi.org/10.4049/jimmunol.0900327
Published: 01 September 2009
View articletitled, 12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis
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Journal Articles

Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression

Toshio Yoshizawa, Deepa Hammaker, David L. Boyle, Maripat Corr, Richard Flavell, Roger Davis, Georg Schett, Gary S. Firestein
Journal: The Journal of Immunology
J Immunol (2009) 183 (2): 1360–1367.
https://doi.org/10.4049/jimmunol.0900483
Published: 15 July 2009
View articletitled, Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression
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Journal Articles

The Rheumatoid Arthritis-Associated Autoantigen hnRNP-A2 (RA33) Is a Major Stimulator of Autoimmunity in Rats with Pristane-Induced Arthritis

Markus H. Hoffmann, Jonatan Tuncel, Karl Skriner, Makiyeh Tohidast-Akrad, Birgit Türk, Serafin Pinol-Roma, Guy Serre, Georg Schett, Josef S. Smolen, Rikard Holmdahl, Günter Steiner
Journal: The Journal of Immunology
J Immunol (2007) 179 (11): 7568–7576.
https://doi.org/10.4049/jimmunol.179.11.7568
Published: 01 December 2007
View articletitled, The Rheumatoid Arthritis-Associated Autoantigen hnRNP-A2 (RA33) Is a Major Stimulator of Autoimmunity in Rats with Pristane-Induced Arthritis
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Journal Articles

Aberrant Expression of the Autoantigen Heterogeneous Nuclear Ribonucleoprotein-A2 (RA33) and Spontaneous Formation of Rheumatoid Arthritis-Associated Anti-RA33 Autoantibodies in TNF-α Transgenic Mice

Silvia Hayer, Makiyeh Tohidast-Akrad, Silva Haralambous, Beatrice Jahn-Schmid, Karl Skriner, Sylvie Trembleau, Hélène Dumortier, Serafin Pinol-Roma, Kurt Redlich, Georg Schett, Sylviane Muller, George Kollias, Josef Smolen, Günter Steiner
Journal: The Journal of Immunology
J Immunol (2005) 175 (12): 8327–8336.
https://doi.org/10.4049/jimmunol.175.12.8327
Published: 15 December 2005
View articletitled, Aberrant Expression of the Autoantigen Heterogeneous Nuclear Ribonucleoprotein-A2 (RA33) and Spontaneous Formation of Rheumatoid Arthritis-Associated Anti-RA33 Autoantibodies in TNF-α Transgenic Mice
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Journal Articles

Interaction between Synovial Inflammatory Tissue and Bone Marrow in Rheumatoid Arthritis

Esther Jimenez-Boj, Kurt Redlich, Birgit Türk, Beatrice Hanslik-Schnabel, Axel Wanivenhaus, Andreas Chott, Josef S. Smolen, Georg Schett
Journal: The Journal of Immunology
J Immunol (2005) 175 (4): 2579–2588.
https://doi.org/10.4049/jimmunol.175.4.2579
Published: 15 August 2005
View articletitled, Interaction between Synovial Inflammatory Tissue and Bone Marrow in Rheumatoid Arthritis
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