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George C. Tsokos
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Journal Articles

PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma

Wenliang Pan, Marc Scherlinger, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2022) 209 (3): 621–628.
https://doi.org/10.4049/jimmunol.2200041
Published: 01 August 2022
View article titled, PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma
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Includes: Supplementary data
Journal Articles

Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis

Sigrun R. Hofmann, Emil Carlsson, Franz Kapplusch, Ana L. Carvalho, Triantafillos Liloglou, Felix Schulze, Susanne Abraham, Sarah Northey, Susanne Russ, Anna E. A. Surace, Nobuya Yoshida, George C. Tsokos, Christian M. Hedrich
Journal: The Journal of Immunology
J Immunol (2021) 207 (1): 55–64.
https://doi.org/10.4049/jimmunol.2100240
Published: 01 July 2021
View article titled, Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4<sup>+</sup> T Cells in Psoriasis
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Includes: Supplementary data
Journal Articles

The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway

Wenliang Pan, Kamalpreet Nagpal, Abel Suárez-Fueyo, Andrew Ferretti, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2021) 206 (8): 1719–1728.
https://doi.org/10.4049/jimmunol.2001266
Published: 15 April 2021
View article titled, The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway
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Includes: Supplementary data
Journal Articles

TNF-α Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-α Production and Enhancing T Cell Activation

Antonios Psarras, Agne Antanaviciute, Adewonuola Alase, Ian Carr, Miriam Wittmann, Paul Emery, George C. Tsokos, Edward M. Vital
Journal: The Journal of Immunology
J Immunol (2021) 206 (4): 785–796.
https://doi.org/10.4049/jimmunol.1901358
Published: 15 February 2021
View article titled, TNF-α Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-α Production and Enhancing T Cell Activation
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Includes: Supplementary data
Journal Articles

cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus

Sigrun R. Hofmann, Katrin Mäbert, Franz Kapplusch, Susanne Russ, Sarah Northey, Michael W. Beresford, George C. Tsokos, Christian M. Hedrich
Journal: The Journal of Immunology
J Immunol (2019) 203 (11): 2807–2816.
https://doi.org/10.4049/jimmunol.1900760
Published: 01 December 2019
View article titled, cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus
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Includes: Supplementary data
Journal Articles

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

Ying Ding, Aixin Yu, George C. Tsokos, Thomas R. Malek
Journal: The Journal of Immunology
J Immunol (2019) 203 (1): 93–104.
https://doi.org/10.4049/jimmunol.1801570
Published: 01 July 2019
View article titled, CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells
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Includes: Supplementary data
Journal Articles

Correction: Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus–Derived T Cells

Eri Katsuyama, Minglu Yan, Katsue Sunahori Watanabe, Mariko Narazaki, Syun Matsushima, Yuriko Yamamura, Sumie Hiramatsu, Keiji Ohashi, Haruki Watanabe, Takayuki Katsuyama, Sonia Zeggar, Nobuya Yoshida, Vaishali R. Moulton, George C. Tsokos, Ken-Ei Sada, Jun Wada
Journal: The Journal of Immunology
J Immunol (2018) 201 (3): 1104.
https://doi.org/10.4049/jimmunol.1800810
Published: 01 August 2018
View article titled, Correction: Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus–Derived T Cells
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Journal Articles

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype

Abel Suárez-Fueyo, Sean J. Bradley, Takayuki Katsuyama, Sarah Solomon, Eri Katsuyama, Vasileios C. Kyttaris, Vaishali R. Moulton, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2018) 200 (9): 3077–3086.
https://doi.org/10.4049/jimmunol.1700588
Published: 01 May 2018
View article titled, Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype
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Includes: Supplementary data
Journal Articles

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury

Mayya Geha, Maria G. Tsokos, Robin E. Bosse, Tatyana Sannikova, Yoichiro Iwakura, Jurandir J. Dalle Lucca, Rene De Waal Malefyt, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2017) 199 (8): 2921–2929.
https://doi.org/10.4049/jimmunol.1700655
Published: 15 October 2017
View article titled, IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury
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Includes: Supplementary data
Journal Articles

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus

Hong Dai, Fan He, George C. Tsokos, Vasileios C. Kyttaris
Journal: The Journal of Immunology
J Immunol (2017) 199 (3): 903–910.
https://doi.org/10.4049/jimmunol.1700418
Published: 01 August 2017
View article titled, IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus
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Includes: Supplementary data
Journal Articles

Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus–Derived T Cells

Eri Katsuyama, Minglu Yan, Katsue Sunahori Watanabe, Syun Matsushima, Yuriko Yamamura, Sumie Hiramatsu, Keiji Ohashi, Haruki Watanabe, Takayuki Katsuyama, Sonia Zeggar, Nobuya Yoshida, Vaishali R. Moulton, George C. Tsokos, Ken-Ei Sada, Jun Wada
Journal: The Journal of Immunology
J Immunol (2017) 198 (11): 4268–4276.
https://doi.org/10.4049/jimmunol.1601705
Published: 01 June 2017
View article titled, Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus–Derived T Cells
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Journal Articles

CD74 Deficiency Mitigates Systemic Lupus Erythematosus–like Autoimmunity and Pathological Findings in Mice

Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K. Sukhova, Min Yang, Lijun Zhang, Vasileios C. Kyttaris, George C. Tsokos, Isaac E. Stillman, Takaharu Ichimura, Joseph V. Bonventre, Peter Libby, Guo-Ping Shi
Journal: The Journal of Immunology
J Immunol (2017) 198 (7): 2568–2577.
https://doi.org/10.4049/jimmunol.1600028
Published: 01 April 2017
View article titled, CD74 Deficiency Mitigates Systemic Lupus Erythematosus–like Autoimmunity and Pathological Findings in Mice
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Journal Articles

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice

Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K. Sukhova, Min Yang, Vasileios C. Kyttaris, Isaac E. Stillman, Bruce Gelb, Peter Libby, George C. Tsokos, Guo-Ping Shi
Journal: The Journal of Immunology
J Immunol (2017) 198 (5): 1846–1854.
https://doi.org/10.4049/jimmunol.1501145
Published: 01 March 2017
View article titled, Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in <em>Fas<sup>lpr</sup></em> Mice
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Journal Articles

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia

Abhigyan Satyam, Lakshmi Kannan, Naoya Matsumoto, Mayya Geha, Peter H. Lapchak, Robin Bosse, Guo-Ping Shi, Jurandir J. Dalle Lucca, Maria G. Tsokos, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2017) 198 (2): 788–797.
https://doi.org/10.4049/jimmunol.1502287
Published: 15 January 2017
View article titled, Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia
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Journal Articles

Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production

Maria P. Karampetsou, Denis Comte, Katalin Kis-Toth, Cox Terhorst, Vasileios C. Kyttaris, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2016) 196 (12): 4915–4924.
https://doi.org/10.4049/jimmunol.1501523
Published: 15 June 2016
View article titled, Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
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Includes: Supplementary data
Journal Articles

Heightened preclinical dysregulation of distinct adaptive and renal-associated mediators in patients who develop nephritis as they transition to systemic lupus erythematosus classification

Melissa Munroe, Jourdan R Anderson, Julie M Robertson, Timothy B Niewold, George C Tsokos, Michael P Keith, Joan T Merrill, Jill P Buyon, John B Harley, Judith A James
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 49.13.
https://doi.org/10.4049/jimmunol.196.Supp.49.13
Published: 01 May 2016
View article titled, Heightened preclinical dysregulation of distinct adaptive and renal-associated mediators in patients who develop nephritis as they transition to systemic lupus erythematosus classification
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Journal Articles

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice

Kotaro Otomo, Tomohiro Koga, Masayuki Mizui, Nobuya Yoshida, Christina Kriegel, Sean Bickerton, Tarek M. Fahmy, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2015) 195 (12): 5533–5537.
https://doi.org/10.4049/jimmunol.1501603
Published: 15 December 2015
View article titled, Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4<sup>+</sup> T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
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Includes: Supplementary data
Journal Articles

Programmed Cell Death 1 and Helios Distinguish TCR-αβ+ Double-Negative (CD4−CD8−) T Cells That Derive from Self-Reactive CD8 T Cells

Noé Rodríguez-Rodríguez, Sokratis A. Apostolidis, Pablo Penaloza-MacMaster, José Manuel Martín Villa, Dan H. Barouch, George C. Tsokos, José C. Crispín
Journal: The Journal of Immunology
J Immunol (2015) 194 (9): 4207–4214.
https://doi.org/10.4049/jimmunol.1402775
Published: 01 May 2015
View article titled, Programmed Cell Death 1 and Helios Distinguish TCR-αβ<sup>+</sup> Double-Negative (CD4<sup>−</sup>CD8<sup>−</sup>) T Cells That Derive from Self-Reactive CD8 T Cells
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Includes: Supplementary data
Journal Articles

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8− IL-17–Producing T Cells

Masayuki Mizui, Tomohiro Koga, Linda A. Lieberman, Jessica Beltran, Nobuya Yoshida, Mark C. Johnson, Roland Tisch, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2014) 193 (5): 2168–2177.
https://doi.org/10.4049/jimmunol.1400977
Published: 01 September 2014
View article titled, IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4<sup>−</sup>CD8<sup>−</sup> IL-17–Producing T Cells
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Includes: Supplementary data
Journal Articles

Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival

Katalin Kis-Toth, George C. Tsokos
Journal: The Journal of Immunology
J Immunol (2014) 192 (9): 4436–4442.
https://doi.org/10.4049/jimmunol.1302909
Published: 01 May 2014
View article titled, Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival
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Includes: Supplementary data