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George N. Pavlakis
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Journal Articles

DNA priming vaccination to induce T cell responses to subdominant conserved HIV epitopes

Barbara K. Felber, Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, James I. Mullins, George N Pavlakis
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 167.11.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.167.11
Published: 01 May 2020
View article titled, DNA priming vaccination to induce T cell responses to subdominant conserved HIV epitopes
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Mechanism of Heterodimeric IL-15 in tumor reduction: Induction of myeloid-lymphoid cell interactions leads to IFN-γ dependent lymphocyte recruitment by dendritic cells into tumors

George N Pavlakis, Cristina Bergamaschi, Dimitri Stellas, Sevasti Karaliota, Bethany Nagy, Vasiliki Stravokefalou, Konstantinos Dimas, Shawn Jensen, Bernard A. Fox, Barbara K. Felber
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 90.13.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.90.13
Published: 01 May 2020
View article titled, Mechanism of Heterodimeric IL-15 in tumor reduction: Induction of myeloid-lymphoid cell interactions leads to IFN-γ dependent lymphocyte recruitment by dendritic cells into tumors
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Regression of murine breast tumors after hetIL-15 monotherapy correlates with a novel population of intratumoral dendritic cells, in addition to increased infiltration of T, NK and cDC1 cells

George N Pavlakis, Sevasti Karaliota, Dimitri Stellas, Cristina Bergamaschi, Vasiliki Stravokefalou, Bethany Nagy, Barbara K. Felber
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 246.14.
DOI: https://doi.org/10.4049/jimmunol.204.Supp.246.14
Published: 01 May 2020
View article titled, Regression of murine breast tumors after hetIL-15 monotherapy correlates with a novel population of intratumoral dendritic cells, in addition to increased infiltration of T, NK and cDC1 cells
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Journal Articles

Novel HIV DNA vaccine changes the immune hierarchy and elicits broad cytotoxic T cell responses targeting subdominant viral epitopes

Barbara K. Felber, Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, James I. Mullins, George N. Pavlakis
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 72.4.
DOI: https://doi.org/10.4049/jimmunol.202.Supp.72.4
Published: 01 May 2019
View article titled, Novel HIV DNA vaccine changes the immune hierarchy and elicits broad cytotoxic T cell responses targeting subdominant viral epitopes
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Journal Articles

Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques

Thomas Musich, Mohammad Arif Rahman, Venkatramanan Mohanram, Leia Miller-Novak, Thorsten Demberg, David J. Venzon, Barbara K. Felber, Genoveffa Franchini, George N. Pavlakis, Marjorie Robert-Guroff
Journal: The Journal of Immunology
J Immunol (2018) 201 (8): 2287–2302.
DOI: https://doi.org/10.4049/jimmunol.1800677
Published: 15 October 2018
View article titled, Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques
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Includes: Supplementary data
Journal Articles

Immune Competition of HIV Epitopes in Draining Lymph Nodes

Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 180.8.
DOI: https://doi.org/10.4049/jimmunol.200.Supp.180.8
Published: 01 May 2018
View article titled, Immune Competition of HIV Epitopes in Draining Lymph Nodes
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hetIL-15 treatment of rhesus macaques is safe and systemically increases effector cytotoxic lymphocytes that infiltrate the lymph nodes.

Dionysios C Watson, Antonio Valentin, Eirini Moysi, Costas Petrovas, Cristina Bergamaschi, Barbara K. Felber, George N Pavlakis
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 199.10.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.199.10
Published: 01 May 2017
View article titled, hetIL-15 treatment of rhesus macaques is safe and systemically increases effector cytotoxic lymphocytes that infiltrate the lymph nodes.
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Vaccine-induced temporal cross-talk between myeloid cells reduces the risk of SIVmac251 acquisition

Monica Vaccari, Shari N Gordon, Slim Fourati, Dallas Brown, Massimiliano Bissa, Melvin N Doster, Brandon K Keele, Luca Schifanella, N Lyianage, Kathryn Foulds, Mario Roederer, David Venzon, Barbara K. Felber, Margherita Rosati, George N Pavlakis, Dan H Barouch, Rafick P Sekaly, Genoveffa Franchini
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 225.23.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.225.23
Published: 01 May 2017
View article titled, Vaccine-induced temporal cross-talk between myeloid cells reduces the risk of SIV<sub>mac251</sub> acquisition
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Modulation of DNA/ALVAC/gp120 vaccine immune-response by vaccination with Insulin-Like Growth Factor 1 (IGF-1)

Massimiliano Bissa, Veronica Galli, Luca Schifanella, Giacomo Gorini, Isabela Silva De Castro, Dallas Brown, Melvin N Doster, Namal Liyanage, Margherita Rosati, Barbara K. Felber, George N Pavlakis, Sanjay Phogat, Genoveffa Franchini
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 225.17.
DOI: https://doi.org/10.4049/jimmunol.198.Supp.225.17
Published: 01 May 2017
View article titled, Modulation of DNA/ALVAC/gp120 vaccine immune-response by vaccination with Insulin-Like Growth Factor 1 (IGF-1)
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DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

Xintao Hu, Antonio Valentin, Frances Dayton, Viraj Kulkarni, Candido Alicea, Margherita Rosati, Bhabadeb Chowdhury, Rajeev Gautam, Kate E. Broderick, Niranjan Y. Sardesai, Malcolm A. Martin, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Journal: The Journal of Immunology
J Immunol (2016) 197 (10): 3999–4013.
DOI: https://doi.org/10.4049/jimmunol.1600697
Published: 15 November 2016
View article titled, DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV
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Includes: Supplementary data
Journal Articles

hetIL-15 therapy results in tumor control by promoting tumor infiltration of CD8+ T cells with increased cytotoxic potential and decreased PD-1 expression.

George N Pavlakis, Sin Man Ng, Konstantinos Dimas, Antonio Valentin, Bethany Nagy, Candido Alicea, Barbara K Felber, Cristina Bergamaschi
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 72.5.
DOI: https://doi.org/10.4049/jimmunol.196.Supp.72.5
Published: 01 May 2016
View article titled, hetIL-15 therapy results in tumor control by promoting tumor infiltration of CD8<sup>+</sup> T cells with increased cytotoxic potential and decreased PD-1 expression.
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Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4+ T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus

Agneta von Gegerfelt, Antonio Valentin, Candido Alicea, Koen K. A. Van Rompay, Marta L. Marthas, David C. Montefiori, George N. Pavlakis, Barbara K. Felber
Journal: The Journal of Immunology
J Immunol (2010) 185 (6): 3348–3358.
DOI: https://doi.org/10.4049/jimmunol.1000572
Published: 15 September 2010
View article titled, Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4<sup>+</sup> T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus
Click here to open pdf in another window PDF for Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4<sup>+</sup> T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus
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Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute Infection

Jacob T. Minang, Matthew T. Trivett, Diane L. Bolton, Charles M. Trubey, Jacob D. Estes, Yuan Li, Jeremy Smedley, Rhonda Pung, Margherita Rosati, Rashmi Jalah, George N. Pavlakis, Barbara K. Felber, Michael Piatak, Jr., Mario Roederer, Jeffrey D. Lifson, David E. Ott, Claes Ohlen
Journal: The Journal of Immunology
J Immunol (2010) 184 (1): 315–326.
DOI: https://doi.org/10.4049/jimmunol.0902410
Published: 14 December 2009
View article titled, Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8<sup>+</sup> T Cell Clones in Rhesus Macaques during Acute Infection
Click here to open pdf in another window PDF for Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8<sup>+</sup> T Cell Clones in Rhesus Macaques during Acute Infection
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Includes: Supplementary data
Journal Articles

Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo

Cristina Bergamaschi, Rashmi Jalah, Viraj Kulkarni, Margherita Rosati, Gen-Mu Zhang, Candido Alicea, Andrei S. Zolotukhin, Barbara K. Felber, George N. Pavlakis
Journal: The Journal of Immunology
J Immunol (2009) 183 (5): 3064–3072.
DOI: https://doi.org/10.4049/jimmunol.0900693
Published: 01 September 2009
View article titled, Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo
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Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection

Constantinos Petrovas, Benjamin Chaon, David R. Ambrozak, David A. Price, J. Joseph Melenhorst, Brenna J. Hill, Christof Geldmacher, Joseph P. Casazza, Pratip K. Chattopadhyay, Mario Roederer, Daniel C. Douek, Yvonne M. Mueller, Jeffrey M. Jacobson, Viraj Kulkarni, Barbara K. Felber, George N. Pavlakis, Peter D. Katsikis, Richard A. Koup
Journal: The Journal of Immunology
J Immunol (2009) 183 (2): 1120–1132.
DOI: https://doi.org/10.4049/jimmunol.0900182
Published: 15 July 2009
View article titled, Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8<sup>+</sup> T Cells in HIV Infection
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Includes: Supplementary data
Journal Articles

Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow

Rosalba Salcedo, Julie A. Hixon, Jimmy K. Stauffer, Rashmi Jalah, Alan D. Brooks, Tahira Khan, Ren-Ming Dai, Loretta Scheetz, Erin Lincoln, Timothy C. Back, Douglas Powell, Arthur A. Hurwitz, Thomas J. Sayers, Robert Kastelein, George N. Pavlakis, Barbara K. Felber, Giorgio Trinchieri, Jon M. Wigginton
Journal: The Journal of Immunology
J Immunol (2009) 182 (7): 4328–4338.
DOI: https://doi.org/10.4049/jimmunol.0800471
Published: 01 April 2009
View article titled, Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow
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IL-15 Receptor alpha increases the stability and promotes secretion and bioactivity of the short signal peptide variant of IL-15 (38.3)

Cristina Bergamaschi, Rashmi Jalah, Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Gen-mu Zhang, Candido Alicea, Andrei S. Zolotukhin, Barbara K. Felber, George N. Pavlakis
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 38.3.
DOI: https://doi.org/10.4049/jimmunol.182.Supp.38.3
Published: 01 April 2009
View article titled, IL-15 Receptor alpha increases the stability and promotes secretion and bioactivity of the short signal peptide variant of IL-15 (38.3)
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Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques

Rabih Halwani, Jean D. Boyer, Bader Yassine-Diab, Elias K. Haddad, Tara M. Robinson, Sanjeev Kumar, Rose Parkinson, Ling Wu, Maninder K. Sidhu, Rebecca Phillipson-Weiner, George N. Pavlakis, Barbara K. Felber, Mark G. Lewis, Anding Shen, Robert F. Siliciano, David B. Weiner, Rafick-Pierre Sekaly
Journal: The Journal of Immunology
J Immunol (2008) 180 (12): 7969–7979.
DOI: https://doi.org/10.4049/jimmunol.180.12.7969
Published: 15 June 2008
View article titled, Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques
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Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes

Zdeněk Hel, Wen-Po Tsai, Elzbieta Tryniszewska, Janos Nacsa, Phillip D. Markham, Mark G. Lewis, George N. Pavlakis, Barbara K. Felber, Jim Tartaglia, Genoveffa Franchini
Journal: The Journal of Immunology
J Immunol (2006) 176 (1): 85–96.
DOI: https://doi.org/10.4049/jimmunol.176.1.85
Published: 01 January 2006
View article titled, Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes
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Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help

Michele A. Kutzler, Tara M. Robinson, Michael A. Chattergoon, Daniel K. Choo, Andrew Y. Choo, Philip Y. Choe, Mathura P. Ramanathan, Rose Parkinson, Sagar Kudchodkar, Yutaka Tamura, Maninder Sidhu, Vidia Roopchand, J. Joseph Kim, George N. Pavlakis, Barbara K. Felber, Thomas A. Waldmann, Jean D. Boyer, David B. Weiner
Journal: The Journal of Immunology
J Immunol (2005) 175 (1): 112–123.
DOI: https://doi.org/10.4049/jimmunol.175.1.112
Published: 01 July 2005
View article titled, Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help
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