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Gerald Krystal
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Journal Articles

Macrophages Are More Potent Immune Suppressors Ex Vivo Than Immature Myeloid-Derived Suppressor Cells Induced by Metastatic Murine Mammary Carcinomas

Melisa J. Hamilton, Momir Bosiljcic, Nancy E. LePard, Elizabeth C. Halvorsen, Victor W. Ho, Judit P. Banáth, Gerald Krystal, Kevin L. Bennewith
Journal: The Journal of Immunology
J Immunol (2014) 192 (1): 512–522.
https://doi.org/10.4049/jimmunol.1300096
Published: 01 January 2014
View article titled, Macrophages Are More Potent Immune Suppressors Ex Vivo Than Immature Myeloid-Derived Suppressor Cells Induced by Metastatic Murine Mammary Carcinomas
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Includes: Supplementary data
Journal Articles

Ly49Q Positively Regulates Type I IFN Production by Plasmacytoid Dendritic Cells in an Immunoreceptor Tyrosine–Based Inhibitory Motif–Dependent Manner

Mir Munir A. Rahim, Lee-Hwa Tai, Angela D. Troke, Ahmad Bakur Mahmoud, Elias Abou-Samra, Justin G. Roy, Amelia Mottashed, Nicholas Ault, Chloe Corbeil, Marie-Line Goulet, Haggag S. Zein, Melisa Hamilton-Valensky, Gerald Krystal, William G. Kerr, Noriko Toyama-Sorimachi, Andrew P. Makrigiannis
Journal: The Journal of Immunology
J Immunol (2013) 190 (8): 3994–4004.
https://doi.org/10.4049/jimmunol.1200873
Published: 15 April 2013
View article titled, Ly49Q Positively Regulates Type I IFN Production by Plasmacytoid Dendritic Cells in an Immunoreceptor Tyrosine–Based Inhibitory Motif–Dependent Manner
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Journal Articles

The Role of SHIP in the Development and Activation of Mouse Mucosal and Connective Tissue Mast Cells

Jens Ruschmann, Frann Antignano, Vivian Lam, Kim Snyder, Connie Kim, Martha Essak, Angela Zhang, Ann Hsu-An Lin, Raghuveer Singh Mali, Reuben Kapur, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2012) 188 (8): 3839–3850.
https://doi.org/10.4049/jimmunol.1003875
Published: 15 April 2012
View article titled, The Role of SHIP in the Development and Activation of Mouse Mucosal and Connective Tissue Mast Cells
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Includes: Supplementary data
Journal Articles

Myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice are only immunosuppressive under serum-free conditions (147.25)

Melisa Hamilton-Valensky, Vivian Lam, Judit Banáth, Gerald Krystal, Kevin Bennewith
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 147.25.
https://doi.org/10.4049/jimmunol.186.Supp.147.25
Published: 01 April 2011
View article titled, Myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice are only immunosuppressive under serum-free conditions (147.25)
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Journal Articles

COX-2 inhibition represses the generation of M2 macrophages and slows tumor progression (111.31)

Victor Ho, Michael Rauh, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2011) 186 (1_Supplement): 111.31.
https://doi.org/10.4049/jimmunol.186.Supp.111.31
Published: 01 April 2011
View article titled, COX-2 inhibition represses the generation of M2 macrophages and slows tumor progression (111.31)
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Journal Articles

MyD88-Dependent SHIP1 Regulates Proinflammatory Signaling Pathways in Dendritic Cells after Monophosphoryl Lipid A Stimulation of TLR4

Caglar Cekic, Carolyn R. Casella, Duygu Sag, Frann Antignano, Joseph Kolb, Jill Suttles, Michael R. Hughes, Gerald Krystal, Thomas C. Mitchell
Journal: The Journal of Immunology
J Immunol (2011) 186 (7): 3858–3865.
https://doi.org/10.4049/jimmunol.1001034
Published: 01 April 2011
View article titled, MyD88-Dependent SHIP1 Regulates Proinflammatory Signaling Pathways in Dendritic Cells after Monophosphoryl Lipid A Stimulation of TLR4
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Includes: Supplementary data
Journal Articles

SHIP Represses Th2 Skewing by Inhibiting IL-4 Production from Basophils

Etsushi Kuroda, Frann Antignano, Victor W. Ho, Michael R. Hughes, Jens Ruschmann, Vivian Lam, Toshiaki Kawakami, William G. Kerr, Kelly M. McNagny, Laura M. Sly, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2011) 186 (1): 323–332.
https://doi.org/10.4049/jimmunol.1002778
Published: 01 January 2011
View article titled, SHIP Represses Th2 Skewing by Inhibiting IL-4 Production from Basophils
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Includes: Supplementary data
Journal Articles

TLR Agonists That Induce IFN-β Abrogate Resident Macrophage Suppression of T Cells

Melisa J. Hamilton, Frann Antignano, Anna von Rossum, Jean-Luc Boucher, Kevin L. Bennewith, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2010) 185 (8): 4545–4553.
https://doi.org/10.4049/jimmunol.1002045
Published: 15 October 2010
View article titled, TLR Agonists That Induce IFN-β Abrogate Resident Macrophage Suppression of T Cells
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Includes: Supplementary data
Journal Articles

SHIP Is Required for Dendritic Cell Maturation

Frann Antignano, Mariko Ibaraki, Connie Kim, Jens Ruschmann, Angela Zhang, Cheryl D. Helgason, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2010) 184 (6): 2805–2813.
https://doi.org/10.4049/jimmunol.0903170
Published: 15 March 2010
View article titled, SHIP Is Required for Dendritic Cell Maturation
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Includes: Supplementary data
Journal Articles

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

Joan Ní Gabhann, Rowan Higgs, Kiva Brennan, Warren Thomas, Jacqueline E. Damen, Nadia Ben Larbi, Gerald Krystal, Caroline A. Jefferies
Journal: The Journal of Immunology
J Immunol (2010) 184 (5): 2314–2320.
https://doi.org/10.4049/jimmunol.0902589
Published: 01 March 2010
View article titled, Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production
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Journal Articles

SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils

Etsushi Kuroda, Victor Ho, Jens Ruschmann, Frann Antignano, Melisa Hamilton, Michael J. Rauh, Andrey Antov, Richard A. Flavell, Laura M. Sly, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2009) 183 (6): 3652–3660.
https://doi.org/10.4049/jimmunol.0900864
Published: 15 September 2009
View article titled, SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils
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Includes: Supplementary data
Journal Articles

SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells

Natasha R. Locke, Scott J. Patterson, Melisa J. Hamilton, Laura M. Sly, Gerald Krystal, Megan K. Levings
Journal: The Journal of Immunology
J Immunol (2009) 183 (2): 975–983.
https://doi.org/10.4049/jimmunol.0803749
Published: 15 July 2009
View article titled, SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells
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Journal Articles

SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo

D. James Haddon, Frann Antignano, Michael R. Hughes, Marie-Renée Blanchet, Lori Zbytnuik, Gerald Krystal, Kelly M. McNagny
Journal: The Journal of Immunology
J Immunol (2009) 183 (1): 228–236.
https://doi.org/10.4049/jimmunol.0900427
Published: 01 July 2009
View article titled, SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo
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Journal Articles

Steel Factor Enhances Supraoptimal Antigen-Induced IL-6 Production from Mast Cells via Activation of Protein Kinase C-β

Kerstin Fehrenbach, Eva Lessmann, Carolin N. Zorn, Marcel Kuhny, Gordon Grochowy, Gerald Krystal, Michael Leitges, Michael Huber
Journal: The Journal of Immunology
J Immunol (2009) 182 (12): 7897–7905.
https://doi.org/10.4049/jimmunol.0801773
Published: 15 June 2009
View article titled, Steel Factor Enhances Supraoptimal Antigen-Induced IL-6 Production from Mast Cells via Activation of Protein Kinase C-β
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Journal Articles

SHIP is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo (139.12)

David James Haddon, Frann Antignano, Michael R Hughes, Marie-Renée Blanchet, Lori Zbytnuik, Gerald Krystal, Kelly Marshall McNagny
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 139.12.
https://doi.org/10.4049/jimmunol.182.Supp.139.12
Published: 01 April 2009
View article titled, SHIP is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation <em>in vivo</em> (139.12)
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Journal Articles

SHIP-deficient dendritic cells suppress T cell proliferation via a nitric oxide independent mechanism (91.9)

Frann Antignano, Melisa Hamilton, Carla Cohen, Victor Ho, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 91.9.
https://doi.org/10.4049/jimmunol.182.Supp.91.9
Published: 01 April 2009
View article titled, SHIP-deficient dendritic cells suppress T cell proliferation via a nitric oxide independent mechanism (91.9)
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Journal Articles

IgE-Induced Mast Cell Survival Requires the Prolonged Generation of Reactive Oxygen Species

Laura M. Sly, Janet Kalesnikoff, Vivian Lam, Dana Wong, Christine Song, Stephanie Omeis, Karen Chan, Corinna W. K. Lee, Reuben P. Siraganian, Juan Rivera, Gerald Krystal
Journal: The Journal of Immunology
J Immunol (2008) 181 (6): 3850–3860.
https://doi.org/10.4049/jimmunol.181.6.3850
Published: 15 September 2008
View article titled, IgE-Induced Mast Cell Survival Requires the Prolonged Generation of Reactive Oxygen Species
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Journal Articles

SHIP1 Negatively Regulates Proliferation of Osteoclast Precursors via Akt-Dependent Alterations in D-Type Cyclins and p27

Ping Zhou, Hideki Kitaura, Steven L. Teitelbaum, Gerald Krystal, F. Patrick Ross, Sunao Takeshita
Journal: The Journal of Immunology
J Immunol (2006) 177 (12): 8777–8784.
https://doi.org/10.4049/jimmunol.177.12.8777
Published: 15 December 2006
View article titled, SHIP1 Negatively Regulates Proliferation of Osteoclast Precursors via Akt-Dependent Alterations in D-Type Cyclins and p27
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Journal Articles

SHIP Down-Regulates FcεR1-Induced Degranulation at Supraoptimal IgE or Antigen Levels

Kerstin Gimborn, Eva Lessmann, Stephan Kuppig, Gerald Krystal, Michael Huber
Journal: The Journal of Immunology
J Immunol (2005) 174 (1): 507–516.
https://doi.org/10.4049/jimmunol.174.1.507
Published: 01 January 2005
View article titled, SHIP Down-Regulates FcεR1-Induced Degranulation at Supraoptimal IgE or Antigen Levels
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Journal Articles

Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells

Valerie Hernandez-Hansen, Alexander J. Smith, Zurab Surviladze, Alexandre Chigaev, Tomas Mazel, Janet Kalesnikoff, Clifford A. Lowell, Gerald Krystal, Larry A. Sklar, Bridget S. Wilson, Janet M. Oliver
Journal: The Journal of Immunology
J Immunol (2004) 173 (1): 100–112.
https://doi.org/10.4049/jimmunol.173.1.100
Published: 01 July 2004
View article titled, Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells
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