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Gordon J. Freeman
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Journal Articles

A comparison of monoclonal antibodies against murine PD-1 and PD-L1

Melissa Tian Bu, Long Yuan, Alyssa Klee, Gordon J Freeman
Journal: The Journal of Immunology
J Immunol (2022) 208 (1_Supplement): 176.05.
https://doi.org/10.4049/jimmunol.208.Supp.176.05
Published: 01 May 2022
View article titled, A comparison of monoclonal antibodies against murine PD-1 and PD-L1
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Phosphoproteomics reveals GITR agonism differentially regulates inflammatory vs. regulatory T cell subsets.

Andrew Davis, Lori Cunningham, Matthew Stokes, Alissa Nelson, Kathryn Abell, Michael Lewis, Roy Scialdone, Than Bui, Emily Alonzo, Gordon J Freeman, Sarah Klein
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 57.15.
https://doi.org/10.4049/jimmunol.206.Supp.57.15
Published: 01 May 2021
View article titled, Phosphoproteomics reveals GITR agonism differentially regulates inflammatory vs. regulatory T cell subsets.
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PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease

Stephanie Rhee, Ethan George Aguilar, Katelyn Paz, Ryan Flynn, Juhi Kuchroo, Peter Sage, Arlene H Sharpe, Gordon J Freeman, Rafi Ahmed, Bruce R Blazar
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 87.8.
https://doi.org/10.4049/jimmunol.204.Supp.87.8
Published: 01 May 2020
View article titled, PD-1 blockade later but not at post-transplant attenuates chronic graft-versus-host disease
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Intracellular Signaling triggered by engagement of PD-1 by PD-L1

Xia Bu, Melissa Bu, Ping Hua, Baogong Zhu, Arlene H Sharpe, Gordon J Freeman
Journal: The Journal of Immunology
J Immunol (2020) 204 (1_Supplement): 78.24.
https://doi.org/10.4049/jimmunol.204.Supp.78.24
Published: 01 May 2020
View article titled, Intracellular Signaling triggered by engagement of PD-1 by PD-L1
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Monitoring PD-1 Signaling in Tumor Infiltrating Lymphocytes

Xia Bu, Vikram R. Juneja, Katheleen M. Mahoney, Carol G. Renolds, Kathleen A. Mcguire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward Greenfield, Philippe Armand, Jerome Ritz, Arlene Sharpe, Gordon J Freeman
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 195.31.
https://doi.org/10.4049/jimmunol.202.Supp.195.31
Published: 01 May 2019
View article titled, Monitoring PD-1 Signaling in Tumor Infiltrating Lymphocytes
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Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells

Filippos Porichis, Meghan G. Hart, Alexandra Massa, Holly L. Everett, Antigoni Morou, Jonathan Richard, Nathalie Brassard, Maxime Veillette, Muska Hassan, Ngoc Le Ly, Jean-Pierre Routy, Gordon J. Freeman, Mathieu Dubé, Andrés Finzi, Daniel E. Kaufmann
Journal: The Journal of Immunology
J Immunol (2018) 201 (3): 971–981.
https://doi.org/10.4049/jimmunol.1701551
Published: 01 August 2018
View article titled, Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells
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Includes: Supplementary data
Journal Articles

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

Peter T. Sage, Frank A. Schildberg, Raymond A. Sobel, Vijay K. Kuchroo, Gordon J. Freeman, Arlene H. Sharpe
Journal: The Journal of Immunology
J Immunol (2018) 200 (8): 2592–2602.
https://doi.org/10.4049/jimmunol.1701231
Published: 15 April 2018
View article titled, Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function
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Includes: Supplementary data
Journal Articles

TIM-1 blockade of the donor graft provides protection against lethal GVHD

Bettina Iliopoulou, Katie Hsu, Antonio Pierini, Gordon J. Freeman, Rosemarie H Dekruyff, Everett Meyer
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 82.19.
https://doi.org/10.4049/jimmunol.198.Supp.82.19
Published: 01 May 2017
View article titled, TIM-1 blockade of the donor graft provides protection against lethal GVHD
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CD8+ T cell-independent mechanisms of PD-1-mediated suppression of anti-tumor immunity in mice

Kristen E Pauken, Vikram Juneja, Kathleen McGuire, Martin LaFleur, Juhi Kuchroo, Peter Sage, Nicolas Chevrier, Gordon J Freeman, Arlene H Sharpe
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 205.11.
https://doi.org/10.4049/jimmunol.198.Supp.205.11
Published: 01 May 2017
View article titled, CD8<sup>+</sup> T cell-independent mechanisms of PD-1-mediated suppression of anti-tumor immunity in mice
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Interaction of both SH2 domains of SHP-2 with a PD-1 homodimer is required for PD-1- mediated inhibition of T cell responses

Nikolaos Patsoukis, Asia Council, Anders Berg, Kankana Bardhan, Jessica Weaver, Kathleen M Mahoney, Gordon J. Freeman, Vassiliki A Boussiotis
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 124.11.
https://doi.org/10.4049/jimmunol.198.Supp.124.11
Published: 01 May 2017
View article titled, Interaction of both SH2 domains of SHP-2 with a PD-1 homodimer is required for PD-1- mediated inhibition of T cell responses
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Journal Articles

PD-1 blockade alters fate commitment of myeloid progenitors during tumor-mediated “emergency” myelopoiesis

Laura Strauss, Jessica Weaver, Gordon J. Freeman, Vassiliki A. Boussiotis
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 56.10.
https://doi.org/10.4049/jimmunol.198.Supp.56.10
Published: 01 May 2017
View article titled, PD-1 blockade alters fate commitment of myeloid progenitors during tumor-mediated “emergency” myelopoiesis
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Journal Articles

PD-L1 binds with B7-1 only in cis on the same cell surface

Apoorvi Chaudhri, Yanping Xiao, Baogong Zhu, Gordon J. Freeman
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 154.11.
https://doi.org/10.4049/jimmunol.198.Supp.154.11
Published: 01 May 2017
View article titled, PD-L1 binds with B7-1 only in cis on the same cell surface
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Blockade of the Neogenin-RGMb-BMP signaling hub inhibits allergen-induced airway hyperreactivity

Sanhong Yu, Krystle leung, Hye-Yeung Kim, Yanping Xiao, Lee A Albacker, Hyun-Jun Lee, Dale T Umetsu, Gordon J Freeman, Rosemarie H Dekruyff
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 192.12.
https://doi.org/10.4049/jimmunol.196.Supp.192.12
Published: 01 May 2016
View article titled, Blockade of the Neogenin-RGMb-BMP signaling hub inhibits allergen-induced airway hyperreactivity
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Journal Articles

BET bromodomain inhibition synergizes with immune checkpoint blockade to facilitate anti-tumor response in a murine model of non-small cell lung cancer harboring activating KRAS mutation

Dennis O Adeegbe, Gordon J Freeman, Kwok-Kin Wong
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 74.10.
https://doi.org/10.4049/jimmunol.196.Supp.74.10
Published: 01 May 2016
View article titled, BET bromodomain inhibition synergizes with immune checkpoint blockade to facilitate anti-tumor response in a murine model of non-small cell lung cancer harboring activating <em>KRAS</em> mutation
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LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

Alba Llibre, Constantino López-Macías, Teresa Marafioti, Hema Mehta, Amy Partridge, Carina Kanzig, Felice Rivellese, Jacob D. Galson, Lucy J. Walker, Paul Milne, Rodney E. Phillips, Dominic F. Kelly, Gordon J. Freeman, Mohey Eldin El Shikh, Paul Klenerman, Christian B. Willberg
Journal: The Journal of Immunology
J Immunol (2016) 196 (5): 2085–2094.
https://doi.org/10.4049/jimmunol.1502462
Published: 01 March 2016
View article titled, LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation
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Includes: Supplementary data
Journal Articles

OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence

Sarah L. Buchan, Teresa Manzo, Barry Flutter, Anne Rogel, Noha Edwards, Lei Zhang, Shivajanani Sivakumaran, Sara Ghorashian, Ben Carpenter, Clare L. Bennett, Gordon J. Freeman, Megan Sykes, Michael Croft, Aymen Al-Shamkhani, Ronjon Chakraverty
Journal: The Journal of Immunology
J Immunol (2015) 194 (1): 125–133.
https://doi.org/10.4049/jimmunol.1401644
Published: 01 January 2015
View article titled, OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8<sup>+</sup> T Cells To Exit Quiescence
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Includes: Supplementary data
Journal Articles

Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection”

Vijay K. Kuchroo, Ana C. Anderson, Gordon J. Freeman
Journal: The Journal of Immunology
J Immunol (2014) 193 (2): 467.
https://doi.org/10.4049/jimmunol.1401123
Published: 15 July 2014
View article titled, Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to Acute <em>Listeria monocytogenes</em> Infection”
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Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer

Cassie K. Chou, Andrea Schietinger, H. Denny Liggitt, Xiaoxia Tan, Sarah Funk, Gordon J. Freeman, Timothy L. Ratliff, Norman M. Greenberg, Philip D. Greenberg
Journal: The Journal of Immunology
J Immunol (2012) 189 (8): 3936–3946.
https://doi.org/10.4049/jimmunol.1201415
Published: 15 October 2012
View article titled, Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer
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Includes: Supplementary data
Journal Articles

Pillars Article: CTLA-4 Can Function as a Negative Regulator of T Cell Activation. Immunity. 1994. 1: 405–413

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker, Peter S. Linsley, Gordon J. Freeman, Jonathan M. Green, Craig B. Thompson, Jeffrey A. Bluestone
Journal: The Journal of Immunology
J Immunol (2011) 187 (7): 3466–3474.
Published: 01 October 2011
View article titled, Pillars Article: CTLA-4 Can Function as a Negative Regulator of T Cell Activation. <em>Immunity</em>. 1994. 1: 405–413
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4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection

Vaiva Vezys, Pablo Penaloza-MacMaster, Daniel L. Barber, Sang-Jun Ha, Bogumila Konieczny, Gordon J. Freeman, Robert S. Mittler, Rafi Ahmed
Journal: The Journal of Immunology
J Immunol (2011) 187 (4): 1634–1642.
https://doi.org/10.4049/jimmunol.1100077
Published: 15 August 2011
View article titled, 4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection
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Includes: Supplementary data