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Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens

Henry Carnes, Brittney Mehrkens, Molly Stegman, Govindarajan Rajagopalan

J Immunol (2019) 202 (1_Supplement): 190.34.

https://doi.org/10.4049/jimmunol.202.Supp.190.34

Published: 01 May 2019

View article titled, Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens

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Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

Zilin Nie, Fatma Aboulnasr, Sekar Natesampillai, Stephen P. Burke, Ashton Krogman, Gary D. Bren, Thomas D. Y. Chung, Jeff R. Anderson, Michele K. Smart, David J. Katzmann, Govindarajan Rajagopalan, Nathan W. Cummins, Andrew D. Badley

J Immunol (2018) 201 (5): 1599.

https://doi.org/10.4049/jimmunol.1800867

Published: 01 September 2018

View article titled, Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

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Dissecting the pathogenic versus protective roles of IFN-γ and IL-17 in staphylococcal toxic shock syndrome and pneumonia using gene targeted HLA-DR3 transgenic mice

Govindarajan Rajagopalan, Ashton Krogman, Vaidehi Chowdhary

J Immunol (2018) 200 (1_Supplement): 117.3.

https://doi.org/10.4049/jimmunol.200.Supp.117.3

Published: 01 May 2018

View article titled, Dissecting the pathogenic versus protective roles of IFN-γ and IL-17 in staphylococcal toxic shock syndrome and pneumonia using gene targeted HLA-DR3 transgenic mice

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Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

J Immunol (2018) 200 (3): 1110–1123.

https://doi.org/10.4049/jimmunol.1701113

Published: 01 February 2018

View article titled, Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

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Includes: Supplementary data

Journal Articles

Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR⁺ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen

Vaidehi R. Chowdhary, Ashton Krogman, Ashenafi Y. Tilahun, Mariam P. Alexander, Chella S. David, Govindarajan Rajagopalan

J Immunol (2017) 198 (11): 4413–4424.

https://doi.org/10.4049/jimmunol.1601991

Published: 01 June 2017

View article titled, Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen

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Includes: Supplementary data

Journal Articles

HLA-DR3 transgenic mice expressing Nur77-GFP reveal early and robust activation of T cells by superantigens during Staphylococcus aureus pneumonia.

Govindarajan Rajagopalan, Melissa Karau, Ashton Krogman, Robin Patel, Chella S David

J Immunol (2016) 196 (1_Supplement): 66.9.

https://doi.org/10.4049/jimmunol.196.Supp.66.9

Published: 01 May 2016

View article titled, HLA-DR3 transgenic mice expressing Nur77-GFP reveal early and robust activation of T cells by superantigens during Staphylococcus aureus pneumonia.

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A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus

Vaidehi R. Chowdhary, Chao Dai, Ashenafi Y. Tilahun, Julie A. Hanson, Michele K. Smart, Joseph P. Grande, Govindarajan Rajagopalan, Shu-Man Fu, Chella S. David

J Immunol (2015) 195 (10): 4660–4667.

https://doi.org/10.4049/jimmunol.1501073

Published: 15 November 2015

View article titled, A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus

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Includes: Supplementary data

Journal Articles

A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020)

Michele Hoffmann, Christopher Parks, Michael Hansen, Govindarajan Rajagopalan, Larry Pease, Adam Schrum, Diana Gil Pages

J Immunol (2015) 194 (1_Supplement): 69.17.

https://doi.org/10.4049/jimmunol.194.Supp.69.17

Published: 01 May 2015

View article titled, A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020)

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Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome

Ashenafi Y. Tilahun, Vaidehi R. Chowdhary, Chella S. David, Govindarajan Rajagopalan

J Immunol (2014) 193 (6): 2919–2930.

https://doi.org/10.4049/jimmunol.1400980

Published: 15 September 2014

View article titled, Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome

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Includes: Supplementary data

Journal Articles

Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306)

Govindarajan Rajagopalan, Ashenafi Tilahun, Vaidehi Chowdhary

J Immunol (2014) 192 (1_Supplement): 184.15.

https://doi.org/10.4049/jimmunol.192.Supp.184.15

Published: 01 May 2014

View article titled, Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306)

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Journal Articles

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Vaidehi R. Chowdhary, Ashenafi Y. Tilahun, Chad R. Clark, Joseph P. Grande, Govindarajan Rajagopalan

J Immunol (2012) 189 (4): 2054–2062.

https://doi.org/10.4049/jimmunol.1201097

Published: 15 August 2012

View article titled, Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

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Includes: Supplementary data

Journal Articles

Detrimental effects of T regulatory cell-promoting IL-2-anti-IL-2 complexes in staphylococcal toxic shock syndrome. (164.13)

Govindarajan Rajagopalan, Ashenafi Tilahun

J Immunol (2012) 188 (1_Supplement): 164.13.

https://doi.org/10.4049/jimmunol.188.Supp.164.13

Published: 01 May 2012

View article titled, Detrimental effects of T regulatory cell-promoting IL-2-anti-IL-2 complexes in staphylococcal toxic shock syndrome. (164.13)

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Journal Articles

Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13)

govindarajan rajagopalan, Ashenafi Y Tilahun, Chella S David

J Immunol (2009) 182 (1_Supplement): 93.13.

https://doi.org/10.4049/jimmunol.182.Supp.93.13

Published: 01 April 2009

View article titled, Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13)

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Journal Articles

Derivation of synergistically acting, neutralizing, chimeric human-mouse anti-SEB monoclonal antibodies (47.35)

Mulualem E. Tilahun, Govindarajan Rajagopalan, Barbara A. Osborne, Richard A. Goldsby

J Immunol (2007) 178 (1_Supplement): S73.

https://doi.org/10.4049/jimmunol.178.Supp.47.35

Published: 01 April 2007

View article titled, Derivation of synergistically acting, neutralizing, chimeric human-mouse anti-SEB monoclonal antibodies (47.35)

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Journal Articles

Chronic low-grade exposure to bacterial superantigens elicits sustained T cell expansion and multiorgan inflammation. Implications for autoimmunity. (130.22)

Govindarajan Rajagopalan, Michele K Smart, Joseph P Grande, Chella S David

J Immunol (2007) 178 (1_Supplement): S232.

https://doi.org/10.4049/jimmunol.178.Supp.130.22

Published: 01 April 2007

View article titled, Chronic low-grade exposure to bacterial superantigens elicits sustained T cell expansion and multiorgan inflammation. Implications for autoimmunity. (130.22)

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Journal Articles

Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain

Govindarajan Rajagopalan, Michele K. Smart, Christopher J. Krco, Chella S. David

J Immunol (2002) 169 (4): 1774–1783.

https://doi.org/10.4049/jimmunol.169.4.1774

Published: 15 August 2002

View article titled, Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain

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NARROW

Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens

Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

Dissecting the pathogenic versus protective roles of IFN-γ and IL-17 in staphylococcal toxic shock syndrome and pneumonia using gene targeted HLA-DR3 transgenic mice

Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR⁺ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen

HLA-DR3 transgenic mice expressing Nur77-GFP reveal early and robust activation of T cells by superantigens during Staphylococcus aureus pneumonia.

A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus

A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020)

Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome

Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306)

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Detrimental effects of T regulatory cell-promoting IL-2-anti-IL-2 complexes in staphylococcal toxic shock syndrome. (164.13)

Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13)

Derivation of synergistically acting, neutralizing, chimeric human-mouse anti-SEB monoclonal antibodies (47.35)

Chronic low-grade exposure to bacterial superantigens elicits sustained T cell expansion and multiorgan inflammation. Implications for autoimmunity. (130.22)

Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain

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