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Journal Articles

Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.

F W van Ginkel, J R McGhee, C Liu, J W Simecka, M Yamamoto, R A Frizzell, E J Sorscher, H Kiyono, D W Pascual
Journal: The Journal of Immunology
J Immunol (1997) 159 (2): 685–693.
DOI: https://doi.org/10.4049/jimmunol.159.2.685
Published: 15 July 1997
View article titled, Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.
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Journal Articles

Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.

M Kubota, C J Miller, K Imaoka, S Kawabata, K Fujihashi, J R McGhee, H Kiyono
Journal: The Journal of Immunology
J Immunol (1997) 158 (11): 5321–5329.
DOI: https://doi.org/10.4049/jimmunol.158.11.5321
Published: 01 June 1997
View article titled, Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.
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Journal Articles

Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.

C O Elson, K W Beagley, A T Sharmanov, K Fujihashi, H Kiyono, G S Tennyson, Y Cong, C A Black, B W Ridwan, J R McGhee
Journal: The Journal of Immunology
J Immunol (1996) 157 (5): 2174–2185.
DOI: https://doi.org/10.4049/jimmunol.157.5.2174
Published: 01 September 1996
View article titled, Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.
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Journal Articles

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

J L VanCott, H F Staats, D W Pascual, M Roberts, S N Chatfield, M Yamamoto, M Coste, P B Carter, H Kiyono, J R McGhee
Journal: The Journal of Immunology
J Immunol (1996) 156 (4): 1504–1514.
DOI: https://doi.org/10.4049/jimmunol.156.4.1504
Published: 15 February 1996
View article titled, Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
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Journal Articles

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

M Marinaro, H F Staats, T Hiroi, R J Jackson, M Coste, P N Boyaka, N Okahashi, M Yamamoto, H Kiyono, H Bluethmann, K Fujihashi, J R McGhee
Journal: The Journal of Immunology
J Immunol (1995) 155 (10): 4621–4629.
DOI: https://doi.org/10.4049/jimmunol.155.10.4621
Published: 15 November 1995
View article titled, Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
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Journal Articles

alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.

K Fujihashi, M Yamamoto, J R McGhee, H Kiyono
Journal: The Journal of Immunology
J Immunol (1993) 151 (12): 6681–6691.
DOI: https://doi.org/10.4049/jimmunol.151.12.6681
Published: 15 December 1993
View article titled, alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.
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Journal Articles

Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.

M Yamamoto, K Fujihashi, K W Beagley, J R McGhee, H Kiyono
Journal: The Journal of Immunology
J Immunol (1993) 150 (1): 106–114.
DOI: https://doi.org/10.4049/jimmunol.150.1.106
Published: 01 January 1993
View article titled, Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.
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Journal Articles

Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.

J Mega, J R McGhee, H Kiyono
Journal: The Journal of Immunology
J Immunol (1992) 148 (7): 2030–2039.
DOI: https://doi.org/10.4049/jimmunol.148.7.2030
Published: 01 April 1992
View article titled, Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.
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Journal Articles

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

T Taguchi, W K Aicher, K Fujihashi, M Yamamoto, J R McGhee, J A Bluestone, H Kiyono
Journal: The Journal of Immunology
J Immunol (1991) 147 (11): 3736–3744.
DOI: https://doi.org/10.4049/jimmunol.147.11.3736
Published: 01 December 1991
View article titled, Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.
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Journal Articles

Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.

D W Pascual, J C Xu-Amano, H Kiyono, J R McGhee, K L Bost
Journal: The Journal of Immunology
J Immunol (1991) 146 (7): 2130–2136.
DOI: https://doi.org/10.4049/jimmunol.146.7.2130
Published: 01 April 1991
View article titled, Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.
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Journal Articles

Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.

Y Kono, K W Beagley, K Fujihashi, J R McGhee, T Taga, T Hirano, T Kishimoto, H Kiyono
Journal: The Journal of Immunology
J Immunol (1991) 146 (6): 1812–1821.
DOI: https://doi.org/10.4049/jimmunol.146.6.1812
Published: 15 March 1991
View article titled, Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.
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Journal Articles

Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone.

K L Bost, B L Clarke, J C Xu, H Kiyono, J R McGhee, D Pascual
Journal: The Journal of Immunology
J Immunol (1990) 145 (12): 4326–4331.
DOI: https://doi.org/10.4049/jimmunol.145.12.4326
Published: 15 December 1990
View article titled, Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone.
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Journal Articles

Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.

K Fujihashi, T Taguchi, J R McGhee, J H Eldridge, M G Bruce, D R Green, B Singh, H Kiyono
Journal: The Journal of Immunology
J Immunol (1990) 145 (7): 2010–2019.
DOI: https://doi.org/10.4049/jimmunol.145.7.2010
Published: 01 October 1990
View article titled, Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.
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Journal Articles

Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera.

W K Aicher, M L McGhee, J R McGhee, J H Eldridge, K W Beagley, T F Meyer, H Kiyono
Journal: The Journal of Immunology
J Immunol (1990) 145 (6): 1745–1753.
DOI: https://doi.org/10.4049/jimmunol.145.6.1745
Published: 15 September 1990
View article titled, Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera.
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Journal Articles

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

T Taguchi, J R McGhee, R L Coffman, K W Beagley, J H Eldridge, K Takatsu, H Kiyono
Journal: The Journal of Immunology
J Immunol (1990) 145 (1): 68–77.
DOI: https://doi.org/10.4049/jimmunol.145.1.68
Published: 01 July 1990
View article titled, Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.
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Journal Articles

Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses.

A Tarkowski, C Lue, Z Moldoveanu, H Kiyono, J R McGhee, J Mestecky
Journal: The Journal of Immunology
J Immunol (1990) 144 (10): 3770–3778.
DOI: https://doi.org/10.4049/jimmunol.144.10.3770
Published: 15 May 1990
View article titled, Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses.
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Journal Articles

Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.

K Fujihashi, H Kiyono, W K Aicher, D R Green, B Singh, J H Eldridge, J R McGhee
Journal: The Journal of Immunology
J Immunol (1989) 143 (11): 3415–3422.
DOI: https://doi.org/10.4049/jimmunol.143.11.3415
Published: 01 December 1989
View article titled, Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.
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Journal Articles

Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue.

T Ogawa, A Tarkowski, M L McGhee, Z Moldoveanu, J Mestecky, H Z Hirsch, W J Koopman, S Hamada, J R McGhee, H Kiyono
Journal: The Journal of Immunology
J Immunol (1989) 142 (4): 1150–1158.
DOI: https://doi.org/10.4049/jimmunol.142.4.1150
Published: 15 February 1989
View article titled, Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue.
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Journal Articles

Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

K W Beagley, J H Eldridge, H Kiyono, M P Everson, W J Koopman, T Honjo, J R McGhee
Journal: The Journal of Immunology
J Immunol (1988) 141 (6): 2035–2042.
DOI: https://doi.org/10.4049/jimmunol.141.6.2035
Published: 15 September 1988
View article titled, Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.
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Journal Articles

Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses.

K Kitamura, H Kiyono, K Fujihashi, J H Eldrige, K W Beagley, J R McGhee
Journal: The Journal of Immunology
J Immunol (1988) 140 (5): 1385–1392.
DOI: https://doi.org/10.4049/jimmunol.140.5.1385
Published: 01 March 1988
View article titled, Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses.
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