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Hal M. Hoffman
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Journal Articles

Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice

Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman
Journal: The Journal of Immunology
J Immunol ji2200550.
DOI: https://doi.org/10.4049/jimmunol.2200550
Published: 31 May 2023
View article titled, Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice
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Includes: Supplementary data
Journal Articles

Choline uptake and metabolism modulate macrophage immunity

Elsa Sanchez-Lopez, Zhenyu Zhong, Alexandra Stubelius, Shannon Renee Sweeney, Laela Booshehri, Laura Antonucci, Ru Liu-Bryan, Alessia Lodi, Robert Terkeltaub, Juan Carlos Lacal, Anne N. Murphy, Hal M Hoffman, Stefano Tiziani, Monica Guma, Michael Karin
Journal: The Journal of Immunology
J Immunol (2019) 202 (1_Supplement): 125.1.
DOI: https://doi.org/10.4049/jimmunol.202.Supp.125.1
Published: 01 May 2019
View article titled, Choline uptake and metabolism modulate macrophage immunity
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Journal Articles

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate

Marina Miller, Arvin B. Tam, James L. Mueller, Peter Rosenthal, Andrew Beppu, Ruth Gordillo, Matthew D. McGeough, Christine Vuong, Taylor A. Doherty, Hal M. Hoffman, Maho Niwa, David H. Broide
Journal: The Journal of Immunology
J Immunol (2017) 198 (8): 3017–3022.
DOI: https://doi.org/10.4049/jimmunol.1601848
Published: 15 April 2017
View article titled, Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate
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Includes: Supplementary data
Journal Articles

NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals

Zhenyu Zhong, Atsushi Umemura, Elsa Sanchez-Lopez, Shuang Liang, Shabnam Shalapour, Jerry Wong, Feng He, Daniela Boassa, Guy Perkins, Syed Raza Ali, Matthew G McGeough, Mark H Ellisman, Ekihiro Seki, Asa B Gustafsson, Hal M Hoffman, Maria T Diaz-Meco, Jorge Moscat, Michael Karin
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 62.5.
DOI: https://doi.org/10.4049/jimmunol.196.Supp.62.5
Published: 01 May 2016
View article titled, NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals
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Journal Articles

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development

Ashley N. Stouch, Alyssa M. McCoy, Rachel M. Greer, Omar Lakhdari, Fiona E. Yull, Timothy S. Blackwell, Hal M. Hoffman, Lawrence S. Prince
Journal: The Journal of Immunology
J Immunol (2016) 196 (8): 3411–3420.
DOI: https://doi.org/10.4049/jimmunol.1500906
Published: 15 April 2016
View article titled, IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development
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Journal Articles

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism

Yu Yao, Jens Vent-Schmidt, Matthew D. McGeough, May Wong, Hal M. Hoffman, Theodore S. Steiner, Megan K. Levings
Journal: The Journal of Immunology
J Immunol (2015) 195 (2): 488–497.
DOI: https://doi.org/10.4049/jimmunol.1403225
Published: 15 July 2015
View article titled, Tr1 Cells, but Not Foxp3<sup>+</sup> Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism
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Includes: Supplementary data
Journal Articles

IκB Kinase Activity Drives Fetal Lung Macrophage Maturation along a Non-M1/M2 Paradigm

Ashley N. Stouch, Rinat Zaynagetdinov, Whitney J. Barham, Amanda M. Stinnett, James C. Slaughter, Fiona E. Yull, Hal M. Hoffman, Timothy S. Blackwell, Lawrence S. Prince
Journal: The Journal of Immunology
J Immunol (2014) 193 (3): 1184–1193.
DOI: https://doi.org/10.4049/jimmunol.1302516
Published: 01 August 2014
View article titled, IκB Kinase Activity Drives Fetal Lung Macrophage Maturation along a Non-M1/M2 Paradigm
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Journal Articles

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

Marina Miller, Peter Rosenthal, Andrew Beppu, James L. Mueller, Hal M. Hoffman, Arvin B. Tam, Taylor A. Doherty, Matthew D. McGeough, Carla A. Pena, Maho Suzukawa, Maho Niwa, David H. Broide
Journal: The Journal of Immunology
J Immunol (2014) 192 (8): 3475–3487.
DOI: https://doi.org/10.4049/jimmunol.1303047
Published: 15 April 2014
View article titled, ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma
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Journal Articles

Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models

Matthew D. McGeough, Carla A. Pena, James L. Mueller, Derek A. Pociask, Lori Broderick, Hal M. Hoffman, Susannah D. Brydges
Journal: The Journal of Immunology
J Immunol (2012) 189 (6): 2707–2711.
DOI: https://doi.org/10.4049/jimmunol.1101737
Published: 15 September 2012
View article titled, Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models
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Includes: Supplementary data
Journal Articles

Correction: An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

Alana A. Shigeoka, James L. Mueller, Amanpreet Kambo, John C. Mathison, Andrew J. King, Wesley F. Hall, Jean da Silva Correia, Richard J. Ulevitch, Hal M. Hoffman, Dianne B. McKay
Journal: The Journal of Immunology
J Immunol (2011) 186 (3): 1880.
DOI: https://doi.org/10.4049/jimmunol.1090136
Published: 01 February 2011
View article titled, Correction: An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury
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Journal Articles

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

Alana A. Shigeoka, James L. Mueller, Amanpreet Kambo, John C. Mathison, Andrew J. King, Wesley F. Hall, Jean da Silva Correia, Richard J. Ulevitch, Hal M. Hoffman, Dianne B. McKay
Journal: The Journal of Immunology
J Immunol (2010) 185 (10): 6277–6285.
DOI: https://doi.org/10.4049/jimmunol.1002330
Published: 15 November 2010
View article titled, An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury
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Journal Articles

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

Jeffrey H. Stack, Kevin Beaumont, Paul D. Larsen, Kimberly S. Straley, Greg W. Henkel, John C. R. Randle, Hal M. Hoffman
Journal: The Journal of Immunology
J Immunol (2005) 175 (4): 2630–2634.
DOI: https://doi.org/10.4049/jimmunol.175.4.2630
Published: 15 August 2005
View article titled, IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients
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