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Hidde L. Ploegh
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Journal Articles

Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells

Ashraful Islam, Novalia Pishesha, Thibault J. Harmand, Hailey Heston, Andrew W. Woodham, Ross W. Cheloha, Djenet Bousbaine, Mohammad Rashidian, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2021) 207 (5): 1468–1477.
https://doi.org/10.4049/jimmunol.2100274
Published: 01 September 2021
View article titled, Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4<sup>+</sup> T Cells
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Includes: Multimedia, Supplementary data
Journal Articles

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination

Yu Kato, Thiago M. Steiner, Hae-Young Park, Rohan O. Hitchcock, Ali Zaid, Jyh Liang Hor, Sapna Devi, Gayle M. Davey, David Vremec, Kirsteen M. Tullett, Peck S. Tan, Fatma Ahmet, Scott N. Mueller, Sylvie Alonso, David M. Tarlinton, Hidde L. Ploegh, Tsuneyasu Kaisho, Lynette Beattie, Jonathan H. Manton, Daniel Fernandez-Ruiz, Ken Shortman, Mireille H. Lahoud, William R. Heath, Irina Caminschi
Journal: The Journal of Immunology
J Immunol (2020) 205 (7): 1842–1856.
https://doi.org/10.4049/jimmunol.2000549
Published: 01 October 2020
View article titled, Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination
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Includes: Multimedia, Supplementary data
Journal Articles

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids

Ross W. Cheloha, Andrew W. Woodham, Djenet Bousbaine, Tong Wang, Shi Liu, John Sidney, Alessandro Sette, Samuel H. Gellman, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2019) 203 (6): 1619–1628.
https://doi.org/10.4049/jimmunol.1900536
Published: 15 September 2019
View article titled, Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids
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Includes: Supplementary data
Journal Articles

Targeted delivery of antigens to CD11b+ cells via nanobodies induces strong antigen-specific T cell and anti-tumor responses

Andrew W. Woodham, Ross W. Cheloha, Jingjing Ling, Mohammad Rashidian, Stephen C. Kolifrath, Maia Mesyngier, Joao N. Duarte, Justin M. Bader, Joseph G. Skeate, Diane M. Da Silva, W. Martin Kast, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 181.6.
https://doi.org/10.4049/jimmunol.200.Supp.181.6
Published: 01 May 2018
View article titled, Targeted delivery of antigens to CD11b<sup>+</sup> cells via nanobodies induces strong antigen-specific T cell and anti-tumor responses
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Journal Articles

Novel epitope derived from Plasmodium berghei liver-stage antigen induces a subset of protective CD8 T cells against sporozoite challenge

Alexander V. Pichugin, Stasya Zarling, Leah Perazzo, Patrick E. Duffy, Hidde L. Ploegh, Urszula Krzych
Journal: The Journal of Immunology
J Immunol (2018) 200 (1_Supplement): 52.21.
https://doi.org/10.4049/jimmunol.200.Supp.52.21
Published: 01 May 2018
View article titled, Novel epitope derived from <em>Plasmodium berghei</em> liver-stage antigen induces a subset of protective CD8 T cells against sporozoite challenge
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Journal Articles

Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets

Eleanor Clancy-Thompson, Gui Zhen Chen, Paul M. Tyler, Mariah M. Servos, Marta Barisa, Patrick J. Brennan, Hidde L. Ploegh, Stephanie K. Dougan
Journal: The Journal of Immunology
J Immunol (2017) 199 (1): 159–171.
https://doi.org/10.4049/jimmunol.1700214
Published: 01 July 2017
View article titled, Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets
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Includes: Supplementary data
Journal Articles

Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs

Joao N. Duarte, Juan J. Cragnolini, Lee Kim Swee, Angelina M. Bilate, Justin Bader, Jessica R. Ingram, Ali Rashidfarrokhi, Tao Fang, Ariën Schiepers, Leo Hanke, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2016) 197 (12): 4838–4847.
https://doi.org/10.4049/jimmunol.1600692
Published: 15 December 2016
View article titled, Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs
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Includes: Supplementary data
Journal Articles

Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection

Chenglong Sun, Stefan A. Schattgen, Prapaporn Pisitkun, Joan P. Jorgensen, Adam T. Hilterbrand, Lucas J. Wang, John A. West, Kathrine Hansen, Kristy A. Horan, Martin R. Jakobsen, Peter O’Hare, Heiko Adler, Ren Sun, Hidde L. Ploegh, Blossom Damania, Jason W. Upton, Katherine A. Fitzgerald, Søren R. Paludan
Journal: The Journal of Immunology
J Immunol (2015) 194 (4): 1819–1831.
https://doi.org/10.4049/jimmunol.1402495
Published: 15 February 2015
View article titled, Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
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Includes: Supplementary data
Journal Articles

Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product

Sungwook Lee, Dongju Kang, Eun A. Ra, Taeyun A. Lee, Hidde L. Ploegh, Boyoun Park
Journal: The Journal of Immunology
J Immunol (2014) 193 (7): 3726–3735.
https://doi.org/10.4049/jimmunol.1400210
Published: 01 October 2014
View article titled, Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product
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Includes: Supplementary data
Journal Articles

Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly

Kaveh Abdi, Nevil J. Singh, Eric Spooner, Benedikt M. Kessler, Sergei Radaev, Larry Lantz, Tsan Sam Xiao, Polly Matzinger, Peter D. Sun, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2014) 192 (12): 6028–6036.
https://doi.org/10.4049/jimmunol.1400159
Published: 15 June 2014
View article titled, Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly
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Journal Articles

Amino Acid Copolymers That Alleviate Experimental Autoimmune Encephalomyelitis In Vivo Interact with Heparan Sulfates and Glycoprotein 96 in APCs

Paul-Albert Koenig, Eric Spooner, Norio Kawamoto, Jack L. Strominger, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2013) 191 (1): 208–216.
https://doi.org/10.4049/jimmunol.1300345
Published: 01 July 2013
View article titled, Amino Acid Copolymers That Alleviate Experimental Autoimmune Encephalomyelitis In Vivo Interact with Heparan Sulfates and Glycoprotein 96 in APCs
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Includes: Supplementary data
Journal Articles

Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling

Jihee Kim, Jiwon Huh, Misun Hwang, Eun-Hye Kwon, Da-Jung Jung, Melanie M. Brinkmann, Myoung Ho Jang, Hidde L. Ploegh, You-Me Kim
Journal: The Journal of Immunology
J Immunol (2013) 190 (10): 5287–5295.
https://doi.org/10.4049/jimmunol.1202767
Published: 15 May 2013
View article titled, Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling
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Includes: Supplementary data
Journal Articles

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

Ana M. Avalos, Oktay Kirak, J. Margit Oelkers, Marina C. Pils, You-Me Kim, Matthias Ottinger, Rudolf Jaenisch, Hidde L. Ploegh, Melanie M. Brinkmann
Journal: The Journal of Immunology
J Immunol (2013) 190 (2): 695–702.
https://doi.org/10.4049/jimmunol.1202342
Published: 15 January 2013
View article titled, Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice
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Includes: Supplementary data
Journal Articles

XBP-1-Deficient Plasmablasts Show Normal Protein Folding but Altered Glycosylation and Lipid Synthesis

Annette M. McGehee, Stephanie K. Dougan, Elizabeth J. Klemm, Guanghou Shui, Boyoun Park, You-Me Kim, Nicki Watson, Markus R. Wenk, Hidde L. Ploegh, Chih-Chi Andrew Hu
Journal: The Journal of Immunology
J Immunol (2009) 183 (6): 3690–3699.
https://doi.org/10.4049/jimmunol.0900953
Published: 15 September 2009
View article titled, XBP-1-Deficient Plasmablasts Show Normal Protein Folding but Altered Glycosylation and Lipid Synthesis
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Includes: Supplementary data
Journal Articles

Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells

Cristina Maria Costantino, Hidde L. Ploegh, David A. Hafler
Journal: The Journal of Immunology
J Immunol (2009) 183 (2): 945–952.
https://doi.org/10.4049/jimmunol.0900921
Published: 15 July 2009
View article titled, Cathepsin S Regulates Class II MHC Processing in Human CD4<sup>+</sup> HLA-DR<sup>+</sup> T Cells
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Journal Articles

Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation

Cristina M. Costantino, Howard C. Hang, Sally C. Kent, David A. Hafler, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2008) 180 (5): 2876–2885.
https://doi.org/10.4049/jimmunol.180.5.2876
Published: 01 March 2008
View article titled, Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation
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Journal Articles

Bridging B Cell and T Cell Recognition of Antigen

In Special Collection:
Pillars of Immunology
Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2007) 179 (11): 7193.
https://doi.org/10.4049/jimmunol.179.11.7193
Published: 01 December 2007
View article titled, Bridging B Cell and T Cell Recognition of Antigen
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Journal Articles

The Peptide Cargo of Class I Molecules: Not Just Passive Passengers

In Special Collection:
Pillars of Immunology
Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2007) 179 (7): 4299–4300.
https://doi.org/10.4049/jimmunol.179.7.4299
Published: 01 October 2007
View article titled, The Peptide Cargo of Class I Molecules: Not Just Passive Passengers
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Journal Articles

Tubulation of Class II MHC Compartments Is Microtubule Dependent and Involves Multiple Endolysosomal Membrane Proteins in Primary Dendritic Cells

Jatin M. Vyas, You-Me Kim, Katerina Artavanis-Tsakonas, J. Christopher Love, Annemarthe G. Van der Veen, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2007) 178 (11): 7199–7210.
https://doi.org/10.4049/jimmunol.178.11.7199
Published: 01 June 2007
View article titled, Tubulation of Class II MHC Compartments Is Microtubule Dependent and Involves Multiple Endolysosomal Membrane Proteins in Primary Dendritic Cells
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Journal Articles

AID−/−μs−/− Mice Are Agammaglobulinemic and Fail to Maintain B220−CD138+ Plasma Cells

Kaori Kumazaki, Boaz Tirosh, René Maehr, Marianne Boes, Tasuku Honjo, Hidde L. Ploegh
Journal: The Journal of Immunology
J Immunol (2007) 178 (4): 2192–2203.
https://doi.org/10.4049/jimmunol.178.4.2192
Published: 15 February 2007
View article titled, AID<sup>−/−</sup>μs<sup>−/−</sup> Mice Are Agammaglobulinemic and Fail to Maintain B220<sup>−</sup>CD138<sup>+</sup> Plasma Cells
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