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Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8⁺ T Cells and Dependence on IL-4 Production

Nobuya Yamaguchi, Shin-ichiro Hiraoka, Takao Mukai, Noritami Takeuchi, Xu-Yu Zhou, Shiro Ono, Mikihiko Kogo, Kyriaki Dunussi-Joannopoulos, Vincent Ling, Stanley Wolf, Hiromi Fujiwara

J Immunol (2004) 172 (3): 1347–1354.

https://doi.org/10.4049/jimmunol.172.3.1347

Published: 01 February 2004

View article titled, Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8+ T Cells and Dependence on IL-4 Production

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Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region

Takayuki Yoshimoto, Masae Furuhata, Sadahiro Kamiya, Masayuki Hisada, Hiroko Miyaji, Yasushi Magami, Koh Yamamoto, Hiromi Fujiwara, Junichiro Mizuguchi

J Immunol (2003) 171 (3): 1352–1359.

https://doi.org/10.4049/jimmunol.171.3.1352

Published: 01 August 2003

View article titled, Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region

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Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation

Xu-Yu Zhou, Yumi Yashiro-Ohtani, Masakiyo Nakahira, Woong Ryeon Park, Ryo Abe, Toshiyuki Hamaoka, Mayumi Naramura, Hua Gu, Hiromi Fujiwara

J Immunol (2002) 168 (8): 3847–3854.

https://doi.org/10.4049/jimmunol.168.8.3847

Published: 15 April 2002

View article titled, Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation

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Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

Masakiyo Nakahira, Hyun-Jong Ahn, Woong-Ryeon Park, Ping Gao, Michio Tomura, Cheung-Seog Park, Toshiyuki Hamaoka, Tsunetaka Ohta, Masashi Kurimoto, Hiromi Fujiwara

J Immunol (2002) 168 (3): 1146–1153.

https://doi.org/10.4049/jimmunol.168.3.1146

Published: 01 February 2002

View article titled, Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

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A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

Masayuki Iwasaki, Takao Mukai, Chigusa Nakajima, Yi-Fu Yang, Ping Gao, Nobuya Yamaguchi, Michio Tomura, Hiromi Fujiwara, Toshiyuki Hamaoka

J Immunol (2001) 167 (12): 6877–6883.

https://doi.org/10.4049/jimmunol.167.12.6877

Published: 15 December 2001

View article titled, A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

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An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

Masakiyo Nakahira, Michio Tomura, Masayuki Iwasaki, Hyun-Jong Ahn, Yang Bian, Toshiyuki Hamaoka, Tsunetaka Ohta, Masashi Kurimoto, Hiromi Fujiwara

J Immunol (2001) 167 (3): 1306–1312.

https://doi.org/10.4049/jimmunol.167.3.1306

Published: 01 August 2001

View article titled, An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

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Granulocyte/Macrophage Colony-Stimulating Factor Inhibits IL-12 production of Mouse Langerhans Cells

Yayoi Tada, Akihiko Asahina, Koichiro Nakamura, Michio Tomura, Hiromi Fujiwara, Kunihiko Tamaki

J Immunol (2000) 164 (10): 5113–5119.

https://doi.org/10.4049/jimmunol.164.10.5113

Published: 15 May 2000

View article titled, Granulocyte/Macrophage Colony-Stimulating Factor Inhibits IL-12 production of Mouse Langerhans Cells

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CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4⁺CD8⁺ Thymocytes and Supports Their Differentiation to the CD4 Lineage

Xu-Yu Zhou, Yumi Yashiro-Ohtani, Kazuhito Toyo-oka, Cheung-Seog Park, Xu-Guang Tai, Toshiyuki Hamaoka, Hiromi Fujiwara

J Immunol (2000) 164 (3): 1260–1268.

https://doi.org/10.4049/jimmunol.164.3.1260

Published: 01 February 2000

View article titled, CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage

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Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

Yumi Yashiro-Ohtani, Xu-Yu Zhou, Kazuhito Toyo-oka, Xu-Guang Tai, Cheung-Seog Park, Toshiyuki Hamaoka, Ryo Abe, Kensuke Miyake, Hiromi Fujiwara

J Immunol (2000) 164 (3): 1251–1259.

https://doi.org/10.4049/jimmunol.164.3.1251

Published: 01 February 2000

View article titled, Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

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A Novel Function of Vα14⁺CD4⁺NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

Michio Tomura, Wen-Gong Yu, Hyun-Jong Ahn, Motozo Yamashita, Yi-Fu Yang, Shiro Ono, Toshiyuki Hamaoka, Tetsu Kawano, Masaru Taniguchi, Yasuhiko Koezuka, Hiromi Fujiwara

J Immunol (1999) 163 (1): 93–101.

https://doi.org/10.4049/jimmunol.163.1.93

Published: 01 July 1999

View article titled, A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

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Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation

Hyun-Jong Ahn, Michio Tomura, Wen-Gong Yu, Masayuki Iwasaki, Woong-Ryeon Park, Toshiyuki Hamaoka, Hiromi Fujiwara

J Immunol (1998) 161 (11): 5893–5900.

https://doi.org/10.4049/jimmunol.161.11.5893

Published: 01 December 1998

View article titled, Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation

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Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells

Cheung-Seog Park, Yumi Yashiro, Xu-Guang Tai, Kazuhito Toyo-oka, Toshiyuki Hamaoka, Hideo Yagita, Ko Okumura, Steven Neben, Hiromi Fujiwara

J Immunol (1998) 160 (12): 5790–5796.

https://doi.org/10.4049/jimmunol.160.12.5790

Published: 15 June 1998

View article titled, Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells

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Journal Articles

A Critical Role for IL-18 in the Proliferation and Activation of NK1.1⁺CD3⁻ Cells

Michio Tomura, Xu-Yu Zhou, Seiji Maruo, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Tadao Tanimoto, Masashi Kurimoto, Hiromi Fujiwara

J Immunol (1998) 160 (10): 4738–4746.

https://doi.org/10.4049/jimmunol.160.10.4738

Published: 15 May 1998

View article titled, A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

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Journal Articles

Differential Capacities of CD4⁺, CD8⁺, and CD4⁻CD8⁻ T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

Michio Tomura, Seiji Maruo, Jie Mu, Xu-Yu Zhou, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Steven Clark, Masashi Kurimoto, Hiromi Fujiwara

J Immunol (1998) 160 (8): 3759–3765.

https://doi.org/10.4049/jimmunol.160.8.3759

Published: 15 April 1998

View article titled, Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

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Studies on in vivo Priming of the TNP-Reactive Cytotoxic Effector Cell System: I. Comparison of the Effects of Intravenous Inoculation with TNP-Conjugated Cells on the Development of Contact Sensitivity and Cell-Mediated Lympholysis

Hiromi Fujiwara, Robert B. Levy, Gene M. Shearer, William D. Terry

J Immunol (1979) 123 (1): 423–425.

https://doi.org/10.4049/jimmunol.123.1.423

Published: 01 July 1979

View article titled, Studies on in vivo Priming of the TNP-Reactive Cytotoxic Effector Cell System: <subtitle>I. Comparison of the Effects of Intravenous Inoculation with TNP-Conjugated Cells on the Development of Contact Sensitivity and Cell-Mediated Lympholysis</subtitle>

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Immunologic Characterization of Tumor-Associated Transplantation Antigens on MM102 Mammary Tumor Eliciting Preferentially Helper T Cell Activity

Hiromi Fujiwara, Hisakazu Aoki, Tetsuo Tsuchida, Toshiyuki Hamaoka

J Immunol (1978) 121 (4): 1591–1595.

https://doi.org/10.4049/jimmunol.121.4.1591

Published: 01 October 1978

View article titled, Immunologic Characterization of Tumor-Associated Transplantation Antigens on MM102 Mammary Tumor Eliciting Preferentially Helper T Cell Activity

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NARROW

Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8⁺ T Cells and Dependence on IL-4 Production

Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region

Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation

Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

Granulocyte/Macrophage Colony-Stimulating Factor Inhibits IL-12 production of Mouse Langerhans Cells

CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4⁺CD8⁺ Thymocytes and Supports Their Differentiation to the CD4 Lineage

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

A Novel Function of Vα14⁺CD4⁺NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-γ Production Following IL-12 Stimulation

Differential Involvement of a Fas-CPP32-Like Protease Pathway in Apoptosis of TCR/CD9-Costimulated, Naive T Cells and TCR-Restimulated, Activated T Cells

A Critical Role for IL-18 in the Proliferation and Activation of NK1.1⁺CD3⁻ Cells

Differential Capacities of CD4⁺, CD8⁺, and CD4⁻CD8⁻ T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

Studies on in vivo Priming of the TNP-Reactive Cytotoxic Effector Cell System: I. Comparison of the Effects of Intravenous Inoculation with TNP-Conjugated Cells on the Development of Contact Sensitivity and Cell-Mediated Lympholysis

Immunologic Characterization of Tumor-Associated Transplantation Antigens on MM102 Mammary Tumor Eliciting Preferentially Helper T Cell Activity

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