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Howard A. Young
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Journal Articles

IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells

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Maria Cimpean, Molly P. Keppel, Anastasiia Gainullina, Changxu Fan, Hyogon Sohn, Nathan C. Schedler, Amanda Swain, Ana Kolicheski, Hannah Shapiro, Howard A. Young, Ting Wang, Maxim N. Artyomov, Megan A. Cooper
Journal: The Journal of Immunology
J Immunol (2023) 211 (10): 1481–1493.
https://doi.org/10.4049/jimmunol.2300283
Published: 25 September 2023
View articletitled, IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells
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Includes: Supplementary data
Journal Articles

Loss of FOXP3+ CD25+ Tregs is independent of type I interferon signaling in lupus-prone mice

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Ngoc Thuy Nguyen, Julio Cesar Valencia, Meredith Ramba, Howard A Young
Journal: The Journal of Immunology
J Immunol (2023) 210 (1_Supplement): 83.19.
https://doi.org/10.4049/jimmunol.210.Supp.83.19
Published: 01 May 2023
View articletitled, Loss of FOXP3+ CD25+ Tregs is independent of type I interferon signaling in lupus-prone mice
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Journal Articles

IL-15 priming alters the regulation of IFN-γ production in NK cells

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Maria Cimpean, Molly P. Keppel, Anastasiia Gainullina, Amanda Swain, Prabhakar Sairam Andhey, Diana He, Howard A. Young, Maxim N. Artyomov, Megan A. Cooper
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 14.04.
https://doi.org/10.4049/jimmunol.206.Supp.14.04
Published: 01 May 2021
View articletitled, IL-15 priming alters the regulation of IFN-γ production in NK cells
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Journal Articles

METABOLIC AND STRUCTURAL MUSCULAR CHANGES DRIVEN BY CHRONIC DISEASE-LIKE IFN-G EXPOSURE

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John Maxwell Fenimore, Danielle Springer, Julio C Valencia, Elijah Edmonston, Howard A Young
Journal: The Journal of Immunology
J Immunol (2021) 206 (1_Supplement): 61.17.
https://doi.org/10.4049/jimmunol.206.Supp.61.17
Published: 01 May 2021
View articletitled, METABOLIC AND STRUCTURAL MUSCULAR CHANGES DRIVEN BY CHRONIC DISEASE-LIKE IFN-G EXPOSURE
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Journal Articles

Report on the 2018 Cancer, Autoimmunity, and Immunology Conference

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Colleen S. Curran, Connie L. Sommers, Howard A. Young, Katarzyna Bourcier, Marie Mancini, Elad Sharon
Journal: The Journal of Immunology
J Immunol (2019) 202 (10): 2823–2828.
https://doi.org/10.4049/jimmunol.1900264
Published: 15 May 2019
View articletitled, Report on the 2018 Cancer, Autoimmunity, and Immunology Conference
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Journal Articles

Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis

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Michelle A Sallin, Shunsuke Sakai, Keith Kauffman, Howard A Young, Jinfang (Jeff) Zhu, Daniel L Barber
Journal: The Journal of Immunology
J Immunol (2017) 198 (1_Supplement): 123.4.
https://doi.org/10.4049/jimmunol.198.Supp.123.4
Published: 01 May 2017
View articletitled, Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis
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Journal Articles

Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology

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Peter A. Szabo, Ankur Goswami, Delfina M. Mazzuca, Kyoungok Kim, David B. O’Gorman, David A. Hess, Ian D. Welch, Howard A. Young, Bhagirath Singh, John K. McCormick, S. M. Mansour Haeryfar
Journal: The Journal of Immunology
J Immunol (2017) 198 (7): 2805–2818.
https://doi.org/10.4049/jimmunol.1601366
Published: 01 April 2017
View articletitled, Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology
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Includes: Supplementary data
Journal Articles

Chronic Interferon-gamma expression triggers a female bias in the development of primary biliary cholangitis

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Howard A Young, Patrick Leung, Koichi Tsuneyama, Julio Valencia, Deborah L Hodge, Seohyun Kim, Tim Back, Megan Karwan, Anand Merchant, Dechun Feng, Bin Gao, Ogyi Park, M Eric Gershwin, Rachel Bae
Journal: The Journal of Immunology
J Immunol (2016) 196 (1_Supplement): 49.10.
https://doi.org/10.4049/jimmunol.196.Supp.49.10
Published: 01 May 2016
View articletitled, Chronic Interferon-gamma expression triggers a female bias in the development of primary biliary cholangitis
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Journal Articles

Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers

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Catalina Lee-Chang, Monica Bodogai, Kanako Moritoh, Xin Chen, Robert Wersto, Ranjan Sen, Howard A. Young, Michael Croft, Luigi Ferrucci, Arya Biragyn
Journal: The Journal of Immunology
J Immunol (2016) 196 (8): 3385–3397.
https://doi.org/10.4049/jimmunol.1502034
Published: 15 April 2016
View articletitled, Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers
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Includes: Supplementary data
Journal Articles

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

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Xing Zhang, Terrence W. Brann, Ming Zhou, Jun Yang, Raphael M. Oguariri, Kristy B. Lidie, Hiromi Imamichi, Da-Wei Huang, Richard A. Lempicki, Michael W. Baseler, Timothy D. Veenstra, Howard A. Young, H. Clifford Lane, Tomozumi Imamichi
Journal: The Journal of Immunology
J Immunol (2011) 186 (8): 4541–4545.
https://doi.org/10.4049/jimmunol.1003389
Published: 15 April 2011
View articletitled, Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN
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Includes: Supplementary data
Journal Articles

Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity

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Maria Cecilia Rodriguez-Galan, Della Reynolds, Silvia G. Correa, Pablo Iribarren, Morihiro Watanabe, Howard A. Young
Journal: The Journal of Immunology
J Immunol (2009) 183 (1): 740–748.
https://doi.org/10.4049/jimmunol.0804166
Published: 01 July 2009
View articletitled, Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity
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Journal Articles

Role of micro-RNA and AU-rich elements in post-transcriptional regulation of interferon gamma (38.1)

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Ram Savan, Rajesh Yalamanchili, Shakeeb Hakim, Howard A. Young
Journal: The Journal of Immunology
J Immunol (2009) 182 (1_Supplement): 38.1.
https://doi.org/10.4049/jimmunol.182.Supp.38.1
Published: 01 April 2009
View articletitled, Role of micro-RNA and AU-rich elements in post-transcriptional regulation of interferon gamma (38.1)
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Journal Articles

In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

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Robin Winkler-Pickett, Howard A. Young, James M. Cherry, John Diehl, John Wine, Timothy Back, William E. Bere, Anna T. Mason, John R. Ortaldo
Journal: The Journal of Immunology
J Immunol (2008) 180 (7): 4495–4506.
https://doi.org/10.4049/jimmunol.180.7.4495
Published: 01 April 2008
View articletitled, In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses
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Journal Articles

NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye

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Koh-Hei Sonoda, Takahiko Nakamura, Howard A. Young, David Hart, Peter Carmeliet, Joan Stein-Streilein
Journal: The Journal of Immunology
J Immunol (2007) 179 (4): 2215–2222.
https://doi.org/10.4049/jimmunol.179.4.2215
Published: 15 August 2007
View articletitled, NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye
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Journal Articles

Dissecting the role of miRNAs in Natural Killer (NK) cells (94.27)

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Ram Savan, Garrison Owens, David J Munroe, Howard A Young
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S175–S176.
https://doi.org/10.4049/jimmunol.178.Supp.94.27
Published: 01 April 2007
View articletitled, Dissecting the role of miRNAs in Natural Killer (NK) cells (94.27)
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Journal Articles

Type I Inteferons Differentially Stimulate Interferon-Gamma Secretion in Human Natural Killer Cells. (95.10)

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Thomas B. Lavoie, Finn Hung, Sara Crisafulli, Della Reynolds, Anthony Scarzello, Karlene Moolchan, Michael Skawinski, Doranelly Koltchev, Sidney Pestka, Howard A Young, William A Clarke
Journal: The Journal of Immunology
J Immunol (2007) 178 (1_Supplement): S178.
https://doi.org/10.4049/jimmunol.178.Supp.95.10
Published: 01 April 2007
View articletitled, Type I Inteferons Differentially Stimulate Interferon-Gamma Secretion in Human Natural Killer Cells. (95.10)
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Journal Articles

NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis

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Carl G. Feng, Mallika Kaviratne, Antonio Gigliotti Rothfuchs, Allen Cheever, Sara Hieny, Howard A. Young, Thomas A. Wynn, Alan Sher
Journal: The Journal of Immunology
J Immunol (2006) 177 (10): 7086–7093.
https://doi.org/10.4049/jimmunol.177.10.7086
Published: 15 November 2006
View articletitled, NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis
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Journal Articles

Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex

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Hyung S. Youn, Joo Y. Lee, Katherine A. Fitzgerald, Howard A. Young, Shizuo Akira, Daniel H. Hwang
Journal: The Journal of Immunology
J Immunol (2005) 175 (5): 3339–3346.
https://doi.org/10.4049/jimmunol.175.5.3339
Published: 01 September 2005
View articletitled, Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex
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Journal Articles

Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

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Katherine C. Brittingham, Gordon Ruthel, Rekha G. Panchal, Claudette L. Fuller, Wilson J. Ribot, Timothy A. Hoover, Howard A. Young, Arthur O. Anderson, Sina Bavari
Journal: The Journal of Immunology
J Immunol (2005) 174 (9): 5545–5552.
https://doi.org/10.4049/jimmunol.174.9.5545
Published: 01 May 2005
View articletitled, Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis
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Journal Articles

Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression

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Maria Cecilia Rodriguez-Galán, Jay H. Bream, Andrew Farr, Howard A. Young
Journal: The Journal of Immunology
J Immunol (2005) 174 (5): 2796–2804.
https://doi.org/10.4049/jimmunol.174.5.2796
Published: 01 March 2005
View articletitled, Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression
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