1-20 of 34
Jan G. J. van de Winkel
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells

Patrick J. Engelberts, Marleen Voorhorst, Janine Schuurman, Tom van Meerten, Joost M. Bakker, Tom Vink, Wendy J. M. Mackus, Esther C. W. Breij, Stefanie Derer, Thomas Valerius, Jan G. J. van de Winkel, Paul W. H. I. Parren, Frank J. Beurskens
Journal: The Journal of Immunology
J Immunol (2016) 197 (12): 4829–4837.
https://doi.org/10.4049/jimmunol.1600811
Published: 15 December 2016
View article titled, Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
Open the PDF for Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Staphylococcus aureus Formyl Peptide Receptor–like 1 Inhibitor (FLIPr) and Its Homologue FLIPr-like Are Potent FcγR Antagonists That Inhibit IgG-Mediated Effector Functions

Annette M. Stemerding, Jörg Köhl, Manoj K. Pandey, Annemarie Kuipers, Jeanette H. Leusen, Peter Boross, Maaike Nederend, Gestur Vidarsson, Annemarie Y. L. Weersink, Jan G. J. van de Winkel, Kok P. M. van Kessel, Jos A. G. van Strijp
Journal: The Journal of Immunology
J Immunol (2013) 191 (1): 353–362.
https://doi.org/10.4049/jimmunol.1203243
Published: 01 July 2013
View article titled, <em>Staphylococcus aureus</em> Formyl Peptide Receptor–like 1 Inhibitor (FLIPr) and Its Homologue FLIPr-like Are Potent FcγR Antagonists That Inhibit IgG-Mediated Effector Functions
Open the PDF for <em>Staphylococcus aureus</em> Formyl Peptide Receptor–like 1 Inhibitor (FLIPr) and Its Homologue FLIPr-like Are Potent FcγR Antagonists That Inhibit IgG-Mediated Effector Functions in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity

Christian Kellner, Tina Maurer, Daniela Hallack, Roland Repp, Jan G. J. van de Winkel, Paul W. H. I. Parren, Thomas Valerius, Andreas Humpe, Martin Gramatzki, Matthias Peipp
Journal: The Journal of Immunology
J Immunol (2012) 189 (10): 5037–5046.
https://doi.org/10.4049/jimmunol.1201321
Published: 15 November 2012
View article titled, Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity
Open the PDF for Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength

Aran F. Labrijn, Theo Rispens, Joyce Meesters, Rebecca J. Rose, Tamara H. den Bleker, Stefan Loverix, Ewald T. J. van den Bremer, Joost Neijssen, Tom Vink, Ignace Lasters, Rob C. Aalberse, Albert J. R. Heck, Jan G. J. van de Winkel, Janine Schuurman, Paul W. H. I. Parren
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 3238–3246.
https://doi.org/10.4049/jimmunol.1003336
Published: 15 September 2011
View article titled, Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength
Open the PDF for Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Epidermal Growth Factor Receptor (EGFR) Antibody-Induced Antibody-Dependent Cellular Cytotoxicity Plays a Prominent Role in Inhibiting Tumorigenesis, Even of Tumor Cells Insensitive to EGFR Signaling Inhibition

Marije B. Overdijk, Sandra Verploegen, Jeroen H. van den Brakel, Jeroen J. Lammerts van Bueren, Tom Vink, Jan G. J. van de Winkel, Paul W. H. I. Parren, Wim K. Bleeker
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 3383–3390.
https://doi.org/10.4049/jimmunol.1003926
Published: 15 September 2011
View article titled, Epidermal Growth Factor Receptor (EGFR) Antibody-Induced Antibody-Dependent Cellular Cytotoxicity Plays a Prominent Role in Inhibiting Tumorigenesis, Even of Tumor Cells Insensitive to EGFR Signaling Inhibition
Open the PDF for Epidermal Growth Factor Receptor (EGFR) Antibody-Induced Antibody-Dependent Cellular Cytotoxicity Plays a Prominent Role in Inhibiting Tumorigenesis, Even of Tumor Cells Insensitive to EGFR Signaling Inhibition in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

Paul V. Beum, Elizabeth M. Peek, Margaret A. Lindorfer, Frank J. Beurskens, Patrick J. Engelberts, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2011) 187 (6): 3438–3447.
https://doi.org/10.4049/jimmunol.1101189
Published: 15 September 2011
View article titled, Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
Open the PDF for Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

Stefan Lohse, Stefanie Derer, Thomas Beyer, Katja Klausz, Matthias Peipp, Jeanette H. W. Leusen, Jan G. J. van de Winkel, Michael Dechant, Thomas Valerius
Journal: The Journal of Immunology
J Immunol (2011) 186 (6): 3770–3778.
https://doi.org/10.4049/jimmunol.1003082
Published: 15 March 2011
View article titled, Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing
Open the PDF for Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing in another window
Add to Citation Manager
Includes: Supplementary data
Journal Articles

Functional Characteristics of the High Affinity IgG Receptor, FcγRI

In Special Collection:
Brief Reviews
Cees E. van der Poel, Robbert M. Spaapen, Jan G. J. van de Winkel, Jeanette H. W. Leusen
Journal: The Journal of Immunology
J Immunol (2011) 186 (5): 2699–2704.
https://doi.org/10.4049/jimmunol.1003526
Published: 01 March 2011
View article titled, Functional Characteristics of the High Affinity IgG Receptor, FcγRI
Open the PDF for Functional Characteristics of the High Affinity IgG Receptor, FcγRI in another window
Add to Citation Manager
Journal Articles

Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors

Michel de Weers, Yu-Tzu Tai, Michael S. van der Veer, Joost M. Bakker, Tom Vink, Daniëlle C. H. Jacobs, Lukas A. Oomen, Matthias Peipp, Thomas Valerius, Jerry W. Slootstra, Tuna Mutis, Wim K. Bleeker, Kenneth C. Anderson, Henk M. Lokhorst, Jan G. J. van de Winkel, Paul W. H. I. Parren
Journal: The Journal of Immunology
J Immunol (2011) 186 (3): 1840–1848.
https://doi.org/10.4049/jimmunol.1003032
Published: 01 February 2011
View article titled, Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
Open the PDF for Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors in another window
Add to Citation Manager
Journal Articles

Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage

Tanja Schneider-Merck, Jeroen J. Lammerts van Bueren, Sven Berger, Kai Rossen, Patrick H.C. van Berkel, Stefanie Derer, Thomas Beyer, Stefan Lohse, Wim K. Bleeker, Matthias Peipp, Paul W. H. I. Parren, Jan G. J. van de Winkel, Thomas Valerius, Michael Dechant
Journal: The Journal of Immunology
J Immunol (2010) 184 (1): 512–520.
https://doi.org/10.4049/jimmunol.0900847
Published: 14 December 2009
View article titled, Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage
Open the PDF for Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage in another window
Add to Citation Manager
Journal Articles

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX

Andrew W. Pawluczkowycz, Frank J. Beurskens, Paul V. Beum, Margaret A. Lindorfer, Jan G. J. van de Winkel, Paul W. H. I. Parren, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2009) 183 (1): 749–758.
https://doi.org/10.4049/jimmunol.0900632
Published: 01 July 2009
View article titled, Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
Open the PDF for Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX in another window
Add to Citation Manager
Journal Articles

Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between FcγRI and FcγRIV

Marielle A. Otten, Gerben J. van der Bij, Sjef J. Verbeek, Falk Nimmerjahn, Jeffrey V. Ravetch, Robert H. J. Beelen, Jan G. J. van de Winkel, Marjolein van Egmond
Journal: The Journal of Immunology
J Immunol (2008) 181 (10): 6829–6836.
https://doi.org/10.4049/jimmunol.181.10.6829
Published: 15 November 2008
View article titled, Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between FcγRI and FcγRIV
Open the PDF for Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between FcγRI and FcγRIV in another window
Add to Citation Manager
Journal Articles

Inside-Out Regulation of FcαRI (CD89) Depends on PP2A

Jantine E. Bakema, Annie Bakker, Simone de Haij, Henk Honing, Madelon Bracke, Leo Koenderman, Gestur Vidarsson, Jan G. J. van de Winkel, Jeanette H. W. Leusen
Journal: The Journal of Immunology
J Immunol (2008) 181 (6): 4080–4088.
https://doi.org/10.4049/jimmunol.181.6.4080
Published: 15 September 2008
View article titled, Inside-Out Regulation of FcαRI (CD89) Depends on PP2A
Open the PDF for Inside-Out Regulation of FcαRI (CD89) Depends on PP2A in another window
Add to Citation Manager
Journal Articles

Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis

Paul V. Beum, Margaret A. Lindorfer, Frank Beurskens, P. Todd Stukenberg, Henk M. Lokhorst, Andrew W. Pawluczkowycz, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor
Journal: The Journal of Immunology
J Immunol (2008) 181 (1): 822–832.
https://doi.org/10.4049/jimmunol.181.1.822
Published: 01 July 2008
View article titled, Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis
Open the PDF for Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis in another window
Add to Citation Manager
Includes: Multimedia, Supplementary data
Journal Articles

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

Lone Skov, Frank J. Beurskens, Claus O. C. Zachariae, Sakari Reitamo, Jessica Teeling, David Satijn, Kim M. Knudsen, Elmieke P. J. Boot, Debra Hudson, Ole Baadsgaard, Paul W. H. I. Parren, Jan G. J. van de Winkel
Journal: The Journal of Immunology
J Immunol (2008) 181 (1): 669–679.
https://doi.org/10.4049/jimmunol.181.1.669
Published: 01 July 2008
View article titled, IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis
Open the PDF for IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis in another window
Add to Citation Manager
Journal Articles

Filamin A Stabilizes FcγRI Surface Expression and Prevents Its Lysosomal Routing

Jeffrey M. Beekman, Cees E. van der Poel, Joke A. van der Linden, Debbie L. C. van den Berg, Peter V. E. van den Berghe, Jan G. J. van de Winkel, Jeanette H. W. Leusen
Journal: The Journal of Immunology
J Immunol (2008) 180 (6): 3938–3945.
https://doi.org/10.4049/jimmunol.180.6.3938
Published: 15 March 2008
View article titled, Filamin A Stabilizes FcγRI Surface Expression and Prevents Its Lysosomal Routing
Open the PDF for Filamin A Stabilizes FcγRI Surface Expression and Prevents Its Lysosomal Routing in another window
Add to Citation Manager
Journal Articles

Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations

Matthias Peipp, Tanja Schneider-Merck, Michael Dechant, Thomas Beyer, Jeroen J. Lammerts van Bueren, Wim K. Bleeker, Paul W. H. I. Parren, Jan G. J. van de Winkel, Thomas Valerius
Journal: The Journal of Immunology
J Immunol (2008) 180 (6): 4338–4345.
https://doi.org/10.4049/jimmunol.180.6.4338
Published: 15 March 2008
View article titled, Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations
Open the PDF for Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations in another window
Add to Citation Manager
Journal Articles

FcR γ-Chain Dependent Signaling in Immature Neutrophils Is Mediated by FcαRI, but Not by FcγRI

Marielle A. Otten, Jeanette H. W. Leusen, Esther Rudolph, Joke A. van der Linden, Robert H. J. Beelen, Jan G. J. van de Winkel, Marjolein van Egmond
Journal: The Journal of Immunology
J Immunol (2007) 179 (5): 2918–2924.
https://doi.org/10.4049/jimmunol.179.5.2918
Published: 01 September 2007
View article titled, FcR γ-Chain Dependent Signaling in Immature Neutrophils Is Mediated by FcαRI, but Not by FcγRI
Open the PDF for FcR γ-Chain Dependent Signaling in Immature Neutrophils Is Mediated by FcαRI, but Not by FcγRI in another window
Add to Citation Manager
Journal Articles

Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor

Michael Dechant, Thomas Beyer, Tanja Schneider-Merck, Wencke Weisner, Matthias Peipp, Jan G. J. van de Winkel, Thomas Valerius
Journal: The Journal of Immunology
J Immunol (2007) 179 (5): 2936–2943.
https://doi.org/10.4049/jimmunol.179.5.2936
Published: 01 September 2007
View article titled, Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor
Open the PDF for Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor in another window
Add to Citation Manager
Journal Articles

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

Jessica L. Teeling, Wendy J. M. Mackus, Luus J. J. M. Wiegman, Jeroen H. N. van den Brakel, Stephen A. Beers, Ruth R. French, Tom van Meerten, Saskia Ebeling, Tom Vink, Jerry W. Slootstra, Paul W. H. I. Parren, Martin J. Glennie, Jan G. J. van de Winkel
Journal: The Journal of Immunology
J Immunol (2006) 177 (1): 362–371.
https://doi.org/10.4049/jimmunol.177.1.362
Published: 01 July 2006
View article titled, The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20
Open the PDF for The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 in another window
Add to Citation Manager